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- W1869256893 abstract "Infections with Opisthorchis viverrini, Clonorchis sinensis and Schistosoma haematobium are classified as Group 1 biological carcinogens: definitive causes of cancer. These worms are metazoan eukaryotes, unlike the other Group 1 carcinogens including human papilloma virus, hepatitis C virus, and Helicobacter pylori. By contrast, infections with phylogenetic relatives of these helminths, also trematodes of the phylum Platyhelminthes and major human pathogens, are not carcinogenic. These inconsistencies prompt several questions, including how might these infections cause cancer? And why is infection with only a few helminth species carcinogenic? Here we present an interpretation of mechanisms contributing to the carcinogenicity of these helminth infections, including roles for catechol estrogen- and oxysterol-metabolites of parasite origin as initiators of carcinogenesis." @default.
- W1869256893 created "2016-06-24" @default.
- W1869256893 creator A5007882171 @default.
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- W1869256893 date "2015-11-01" @default.
- W1869256893 modified "2023-10-10" @default.
- W1869256893 title "Why Does Infection With Some Helminths Cause Cancer?" @default.
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- W1869256893 doi "https://doi.org/10.1016/j.trecan.2015.08.011" @default.
- W1869256893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4657143" @default.
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- W1869256893 hasPublicationYear "2015" @default.
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