FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1869295639> ?p ?o ?g. }

• W1869295639 endingPage "2923" @default.
• W1869295639 startingPage "2913" @default.
• W1869295639 abstract "Abstract A general protocol for palladium‐catalysed CH mono‐ and di‐fluorination of highly substituted arylpyrazoles is reported. Coupling pathways and substrate limitations are discussed in the light of complementary mechanistic experimental and density functional theory (DFT) studies. The mono‐ and di‐ ortho ‐fluorination of arylpyrazoles having substituted pyrazole groups and ortho ‐, meta ‐, or para ‐substituted arene moieties is achieved. Various pyrazole groups can efficiently promote the direct CH activation/fluorination of substrates bearing valuable reactive ester, cyano, halide and nitro functions. The presence of methoxy, methyl and trifluoromethyl is tolerated on the pyrazole directing groups. However, steric substituent effects have a marked influence which is evidenced by calculations. DFT modelling suggested also a previously unseen outer‐sphere oxidative addition of N ‐fluorobenzenesulfonimide (NFSI) to Pd(II) as an alternative mechanism to the commonly assumed Pd(II)/Pd(IV) process. This unprecedented proposal, which is supported by the mass spectrometry identification of a key Pd(II) monomer under the stoichiometric conditions deserves more attention. The influence of elaborate highly substituted directing groups on the course of Pd‐catalysed fluorination has generally received limited attention although this question has a crucial synthetic utility; herein, appropriate conditions for isolating pure products are reported. magnified image" @default.
• W1869295639 created "2016-06-24" @default.
• W1869295639 creator A5001680084 @default.
• W1869295639 creator A5027639412 @default.
• W1869295639 creator A5044656418 @default.
• W1869295639 creator A5070700328 @default.
• W1869295639 creator A5078257188 @default.
• W1869295639 date "2015-09-10" @default.
• W1869295639 modified "2023-10-18" @default.
• W1869295639 title "Palladium-Catalysed CH Bond Electrophilic Fluorination of Highly Substituted Arylpyrazoles: Experimental and DFT Mechanistic Insights" @default.
• W1869295639 cites W123872719 @default.
• W1869295639 cites W1498073544 @default.
• W1869295639 cites W1575681578 @default.
• W1869295639 cites W1964837435 @default.
• W1869295639 cites W1966182479 @default.
• W1869295639 cites W1969471704 @default.
• W1869295639 cites W1971911526 @default.
• W1869295639 cites W1973656792 @default.
• W1869295639 cites W1977886807 @default.
• W1869295639 cites W1980193340 @default.
• W1869295639 cites W1986353432 @default.
• W1869295639 cites W1986614779 @default.
• W1869295639 cites W1991200342 @default.
• W1869295639 cites W1996846370 @default.
• W1869295639 cites W1999350732 @default.
• W1869295639 cites W1999535730 @default.
• W1869295639 cites W2006683822 @default.
• W1869295639 cites W2012780101 @default.
• W1869295639 cites W2017146152 @default.
• W1869295639 cites W2017860035 @default.
• W1869295639 cites W2021231925 @default.
• W1869295639 cites W2026381637 @default.
• W1869295639 cites W2030212357 @default.
• W1869295639 cites W2030699693 @default.
• W1869295639 cites W2038767330 @default.
• W1869295639 cites W2038974680 @default.
• W1869295639 cites W2039891316 @default.
• W1869295639 cites W2041860305 @default.
• W1869295639 cites W2042737941 @default.
• W1869295639 cites W2055327257 @default.
• W1869295639 cites W2057086900 @default.
• W1869295639 cites W2063809441 @default.
• W1869295639 cites W2066309940 @default.
• W1869295639 cites W2070160936 @default.
• W1869295639 cites W2071765830 @default.
• W1869295639 cites W2083989420 @default.
• W1869295639 cites W2084005417 @default.
• W1869295639 cites W2087676073 @default.
• W1869295639 cites W2091801682 @default.
• W1869295639 cites W2093815452 @default.
• W1869295639 cites W2094065729 @default.
• W1869295639 cites W2095474273 @default.
• W1869295639 cites W2098832660 @default.
• W1869295639 cites W2099531933 @default.
• W1869295639 cites W2104919283 @default.
• W1869295639 cites W2111565455 @default.
• W1869295639 cites W2112850441 @default.
• W1869295639 cites W2119203509 @default.
• W1869295639 cites W2120436984 @default.
• W1869295639 cites W2122480383 @default.
• W1869295639 cites W2127973843 @default.
• W1869295639 cites W2128738117 @default.
• W1869295639 cites W2137001128 @default.
• W1869295639 cites W2138484542 @default.
• W1869295639 cites W2139552174 @default.
• W1869295639 cites W2142918406 @default.
• W1869295639 cites W2147320580 @default.
• W1869295639 cites W2149943032 @default.
• W1869295639 cites W2151220474 @default.
• W1869295639 cites W2151416474 @default.
• W1869295639 cites W2154748200 @default.
• W1869295639 cites W2159670464 @default.
• W1869295639 cites W2160679238 @default.
• W1869295639 cites W2161076320 @default.
• W1869295639 cites W2321812129 @default.
• W1869295639 cites W2329487497 @default.
• W1869295639 cites W2333129245 @default.
• W1869295639 cites W2951069975 @default.
• W1869295639 cites W2951252043 @default.
• W1869295639 cites W4235935841 @default.
• W1869295639 cites W4240960646 @default.
• W1869295639 cites W4362231989 @default.
• W1869295639 doi "https://doi.org/10.1002/adsc.201500321" @default.
• W1869295639 hasPublicationYear "2015" @default.
• W1869295639 type Work @default.
• W1869295639 sameAs 1869295639 @default.
• W1869295639 citedByCount "28" @default.
• W1869295639 countsByYear W18692956392016 @default.
• W1869295639 countsByYear W18692956392017 @default.
• W1869295639 countsByYear W18692956392018 @default.
• W1869295639 countsByYear W18692956392019 @default.
• W1869295639 countsByYear W18692956392020 @default.
• W1869295639 countsByYear W18692956392021 @default.
• W1869295639 countsByYear W18692956392022 @default.
• W1869295639 crossrefType "journal-article" @default.
• W1869295639 hasAuthorship W1869295639A5001680084 @default.
• W1869295639 hasAuthorship W1869295639A5027639412 @default.
• W1869295639 hasAuthorship W1869295639A5044656418 @default.

• next