Matches in SemOpenAlex for { <https://semopenalex.org/work/W1869308684> ?p ?o ?g. }
- W1869308684 endingPage "207" @default.
- W1869308684 startingPage "199" @default.
- W1869308684 abstract "Within the broader framework of facilitating investigations into the inherent responses of restricted neuronal phenotypes devoid of their in vivo afferents, serum- and steroid-free cultures enriched in corticotropin-releasing hormone (CRH), arginine vasopressin (AVP), and β-endorphin (β-END) peptidergic neurons were prepared from the hypothalamic paraventricular (PVN: CRH and AVP) and/or arcuate (ARC: β-END) nuclei of juvenile male rats. The functional viability of these ARC/PVN cultures was verified by their ability to synthesize and secrete CRH, AVP, and β-END under basal and depolarizing (veratridine) conditions in vitro. Peptide secretion was shown to be Ca2+ and Na+ dependent in that it was blocked in the presence of veraspamil and tetrodotoxin, respectively. Exposure of ARC/PVN cocultures to the glucocorticoid dexamethasone (DEX) resulted in a dose-dependent increase of CRH secretion and an inhibition of AVP and β-END; the CRH responses deviated strikingly from predictions based on in vivo experiments. Steroid withdrawal or treatment with the glucocorticoid receptor antagonist RU38486 reversed these trends. Opposite effects of DEX on CRH secretion were observed in cultures consisting of PVN cells only. Supported by studies using an opioid receptor agonist (morphine) and antagonist (naloxone), these observations demonstrate that ARC-derived (β-END) neurons modulate the responses of PVN neurons to DEX.—Hellbach, S., Gärtner, P., Deicke, J., Fischer, D., Hassan, A. H. S., Almeida, O. F. X. Inherent glucocorticoid response potential of isolated hypothalamic neuroendocrine neurons. FASEB J. 12, 199–207 (1998)" @default.
- W1869308684 created "2016-06-24" @default.
- W1869308684 creator A5000053965 @default.
- W1869308684 creator A5010542983 @default.
- W1869308684 creator A5015150145 @default.
- W1869308684 creator A5031431640 @default.
- W1869308684 creator A5051315126 @default.
- W1869308684 creator A5063922971 @default.
- W1869308684 date "1998-02-01" @default.
- W1869308684 modified "2023-09-27" @default.
- W1869308684 title "Inherent glucocorticoid response potential of isolated hypothalamic neuroendocrine neurons" @default.
- W1869308684 cites W118620651 @default.
- W1869308684 cites W1514751206 @default.
- W1869308684 cites W1894125867 @default.
- W1869308684 cites W1967015515 @default.
- W1869308684 cites W1970678441 @default.
- W1869308684 cites W1972356004 @default.
- W1869308684 cites W1983550370 @default.
- W1869308684 cites W1987035381 @default.
- W1869308684 cites W1987183940 @default.
- W1869308684 cites W1995397241 @default.
- W1869308684 cites W1998047733 @default.
- W1869308684 cites W2003228325 @default.
- W1869308684 cites W2007309883 @default.
- W1869308684 cites W2007470655 @default.
- W1869308684 cites W2011354265 @default.
- W1869308684 cites W2014619876 @default.
- W1869308684 cites W2014779810 @default.
- W1869308684 cites W2019833164 @default.
- W1869308684 cites W2022842950 @default.
- W1869308684 cites W2025154452 @default.
- W1869308684 cites W2027002868 @default.
- W1869308684 cites W2028075396 @default.
- W1869308684 cites W2028780545 @default.
- W1869308684 cites W2029949091 @default.
- W1869308684 cites W2032751475 @default.
- W1869308684 cites W2033213266 @default.
- W1869308684 cites W2033690418 @default.
- W1869308684 cites W2034223321 @default.
- W1869308684 cites W2039839501 @default.
- W1869308684 cites W2047620892 @default.
- W1869308684 cites W2049912478 @default.
- W1869308684 cites W2053249848 @default.
- W1869308684 cites W2055790883 @default.
- W1869308684 cites W2056126846 @default.
- W1869308684 cites W2058917294 @default.
- W1869308684 cites W2061430646 @default.
- W1869308684 cites W2068729182 @default.
- W1869308684 cites W2070045694 @default.
- W1869308684 cites W2073397828 @default.
- W1869308684 cites W2075977089 @default.
- W1869308684 cites W2077801286 @default.
- W1869308684 cites W2078757965 @default.
- W1869308684 cites W2079643837 @default.
- W1869308684 cites W2081741081 @default.
- W1869308684 cites W2082662547 @default.
- W1869308684 cites W2086646313 @default.
- W1869308684 cites W2098193815 @default.
- W1869308684 cites W2111266201 @default.
- W1869308684 cites W2254356987 @default.
- W1869308684 cites W4232879824 @default.
- W1869308684 cites W4233639958 @default.
- W1869308684 doi "https://doi.org/10.1096/fasebj.12.2.199" @default.
- W1869308684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9472985" @default.
- W1869308684 hasPublicationYear "1998" @default.
- W1869308684 type Work @default.
- W1869308684 sameAs 1869308684 @default.
- W1869308684 citedByCount "17" @default.
- W1869308684 countsByYear W18693086842013 @default.
- W1869308684 countsByYear W18693086842014 @default.
- W1869308684 countsByYear W18693086842018 @default.
- W1869308684 countsByYear W18693086842020 @default.
- W1869308684 countsByYear W18693086842023 @default.
- W1869308684 crossrefType "journal-article" @default.
- W1869308684 hasAuthorship W1869308684A5000053965 @default.
- W1869308684 hasAuthorship W1869308684A5010542983 @default.
- W1869308684 hasAuthorship W1869308684A5015150145 @default.
- W1869308684 hasAuthorship W1869308684A5031431640 @default.
- W1869308684 hasAuthorship W1869308684A5051315126 @default.
- W1869308684 hasAuthorship W1869308684A5063922971 @default.
- W1869308684 hasConcept C126322002 @default.
- W1869308684 hasConcept C134018914 @default.
- W1869308684 hasConcept C170493617 @default.
- W1869308684 hasConcept C178790620 @default.
- W1869308684 hasConcept C185592680 @default.
- W1869308684 hasConcept C2776370428 @default.
- W1869308684 hasConcept C2776986425 @default.
- W1869308684 hasConcept C2777003273 @default.
- W1869308684 hasConcept C2778458438 @default.
- W1869308684 hasConcept C2778938600 @default.
- W1869308684 hasConcept C2780004078 @default.
- W1869308684 hasConcept C2780841215 @default.
- W1869308684 hasConcept C50952357 @default.
- W1869308684 hasConcept C537181965 @default.
- W1869308684 hasConcept C59493245 @default.
- W1869308684 hasConcept C71924100 @default.
- W1869308684 hasConcept C86803240 @default.
- W1869308684 hasConceptScore W1869308684C126322002 @default.