FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1869398506> ?p ?o ?g. }

• W1869398506 abstract "Background Omega 6 plays a vital role in many physiological functions but there is controversy concerning its effect on cardiovascular disease (CVD) risk. There is conflicting evidence whether increasing or decreasing omega 6 intake results in beneficial effects. Objectives The two primary objectives of this Cochrane review were to determine the effectiveness of: 1. Increasing omega 6 (Linoleic acid (LA), Gamma‐linolenic acid (GLA), Dihomo‐gamma‐linolenic acid (DGLA), Arachidonic acid (AA), or any combination) intake in place of saturated or monounsaturated fats or carbohydrates for the primary prevention of CVD. 2. Decreasing omega 6 (LA, GLA, DGLA, AA, or any combination) intake in place of carbohydrates or protein (or both) for the primary prevention of CVD. Search methods We searched the following electronic databases up to 23 September 2014: the Cochrane Central Register of Controlled Trials (CENTRAL) on the Cochrane Library (Issue 8 of 12, 2014); MEDLINE (Ovid) (1946 to September week 2, 2014); EMBASE Classic and EMBASE (Ovid) (1947 to September 2014); Web of Science Core Collection (Thomson Reuters) (1990 to September 2014); Database of Abstracts of Reviews of Effects (DARE) and Health Technology Assessment Database, and Health Economics Evaluations Database on the Cochrane Library (Issue 3 of 4, 2014). We searched trial registers and reference lists of reviews for further studies. We applied no language restrictions. Selection criteria Randomised controlled trials (RCTs) of interventions stating an intention to increase or decrease omega 6 fatty acids, lasting at least six months, and including healthy adults or adults at high risk of CVD. The comparison group was given no advice, no supplementation, a placebo, a control diet, or continued with their usual diet. The outcomes of interest were CVD clinical events (all‐cause mortality, cardiovascular mortality, non‐fatal end points) and CVD risk factors (changes in blood pressure, changes in blood lipids, occurrence of type 2 diabetes). We excluded trials involving exercise or multifactorial interventions to avoid confounding. Data collection and analysis Two review authors independently selected trials for inclusion, extracted the data, and assessed the risk of bias in the included trials. Main results We included four RCTs (five papers) that randomised 660 participants. No ongoing trials were identified. All included trials had at least one domain with an unclear risk of bias. There were no RCTs of omega 6 intake reporting CVD clinical events. Three trials investigated the effect of increased omega 6 intake on lipid levels (total cholesterol, low density lipoprotein (LDL‐cholesterol), and high density lipoprotein (HDL‐cholesterol)), two trials reported triglycerides, and two trials reported blood pressure (diastolic and systolic blood pressure). Two trials, one with two relevant intervention arms, investigated the effect of decreased omega 6 intake on blood pressure parameters and lipid levels (total cholesterol, LDL‐cholesterol, and HDL‐cholesterol) and one trial reported triglycerides. Our analyses found no statistically significant effects of either increased or decreased omega 6 intake on CVD risk factors. Two studies were supported by funding from the UK Food Standards Agency and Medical Research Council. One study was supported by Lipid Nutrition, a commercial company in the Netherlands and the Dutch Ministry of Economic Affairs. The final study was supported by grants from the Finnish Food Research Foundation, Finnish Heart Research Foundation, Aarne and Aili Turnen Foundation, and the Research Council for Health, Academy of Finland. Authors' conclusions We found no studies examining the effects of either increased or decreased omega 6 on our primary outcome CVD clinical endpoints and insufficient evidence to show an effect of increased or decreased omega 6 intake on CVD risk factors such as blood lipids and blood pressure. Very few trials were identified with a relatively small number of participants randomised. There is a need for larger well conducted RCTs assessing cardiovascular events as well as cardiovascular risk factors." @default.
• W1869398506 created "2016-06-24" @default.
• W1869398506 creator A5007103570 @default.
• W1869398506 creator A5020324492 @default.
• W1869398506 creator A5052174968 @default.
• W1869398506 creator A5058454706 @default.
• W1869398506 creator A5065359398 @default.
• W1869398506 creator A5076405762 @default.
• W1869398506 date "2015-11-16" @default.
• W1869398506 modified "2023-09-27" @default.
• W1869398506 title "Omega 6 fatty acids for the primary prevention of cardiovascular disease" @default.
• W1869398506 cites W1524577738 @default.
• W1869398506 cites W1596389679 @default.
• W1869398506 cites W174675987 @default.
• W1869398506 cites W1821582270 @default.
• W1869398506 cites W1859445442 @default.
• W1869398506 cites W1892253401 @default.
• W1869398506 cites W1896271480 @default.
• W1869398506 cites W1910588805 @default.
• W1869398506 cites W1914089044 @default.
• W1869398506 cites W1916791904 @default.
• W1869398506 cites W1926128061 @default.
• W1869398506 cites W1936171856 @default.
• W1869398506 cites W1940521720 @default.
• W1869398506 cites W1956100978 @default.
• W1869398506 cites W1966349223 @default.
• W1869398506 cites W1967305160 @default.
• W1869398506 cites W1970510232 @default.
• W1869398506 cites W1974565667 @default.
• W1869398506 cites W1980541542 @default.
• W1869398506 cites W1981328190 @default.
• W1869398506 cites W1989333956 @default.
• W1869398506 cites W1990065296 @default.
• W1869398506 cites W1992014599 @default.
• W1869398506 cites W1997127587 @default.
• W1869398506 cites W2000222183 @default.
• W1869398506 cites W2001080393 @default.
• W1869398506 cites W2002115434 @default.
• W1869398506 cites W2004223655 @default.
• W1869398506 cites W2004813328 @default.
• W1869398506 cites W2005622814 @default.
• W1869398506 cites W2006315712 @default.
• W1869398506 cites W2007721532 @default.
• W1869398506 cites W2008462333 @default.
• W1869398506 cites W2014589167 @default.
• W1869398506 cites W2016263593 @default.
• W1869398506 cites W2016608474 @default.
• W1869398506 cites W2019216107 @default.
• W1869398506 cites W2021435865 @default.
• W1869398506 cites W2023667174 @default.
• W1869398506 cites W2024633333 @default.
• W1869398506 cites W2027210388 @default.
• W1869398506 cites W2028054185 @default.
• W1869398506 cites W2030455177 @default.
• W1869398506 cites W2031404119 @default.
• W1869398506 cites W2032067861 @default.
• W1869398506 cites W2033451677 @default.
• W1869398506 cites W2034137313 @default.
• W1869398506 cites W2035874642 @default.
• W1869398506 cites W2037466593 @default.
• W1869398506 cites W2040025996 @default.
• W1869398506 cites W2041513724 @default.
• W1869398506 cites W2041754281 @default.
• W1869398506 cites W2042363437 @default.
• W1869398506 cites W2047012917 @default.
• W1869398506 cites W2050217161 @default.
• W1869398506 cites W2051038117 @default.
• W1869398506 cites W2055990136 @default.
• W1869398506 cites W2058240826 @default.
• W1869398506 cites W2059064279 @default.
• W1869398506 cites W2060579749 @default.
• W1869398506 cites W2061222229 @default.
• W1869398506 cites W2063681764 @default.
• W1869398506 cites W2063899206 @default.
• W1869398506 cites W2064468000 @default.
• W1869398506 cites W2064726497 @default.
• W1869398506 cites W2065473151 @default.
• W1869398506 cites W2071973016 @default.
• W1869398506 cites W2072559372 @default.
• W1869398506 cites W2075206084 @default.
• W1869398506 cites W2077425819 @default.
• W1869398506 cites W2081730098 @default.
• W1869398506 cites W2083532131 @default.
• W1869398506 cites W2085980486 @default.
• W1869398506 cites W2088550457 @default.
• W1869398506 cites W2089451891 @default.
• W1869398506 cites W2092730774 @default.
• W1869398506 cites W2093350460 @default.
• W1869398506 cites W2094968487 @default.
• W1869398506 cites W2097226936 @default.
• W1869398506 cites W2097301645 @default.
• W1869398506 cites W2098287260 @default.
• W1869398506 cites W2100476887 @default.
• W1869398506 cites W2101872116 @default.
• W1869398506 cites W2102323857 @default.
• W1869398506 cites W2103018276 @default.
• W1869398506 cites W2105953302 @default.
• W1869398506 cites W2106876061 @default.
• W1869398506 cites W2107074082 @default.
• W1869398506 cites W2107338617 @default.

• next