Matches in SemOpenAlex for { <https://semopenalex.org/work/W1869439357> ?p ?o ?g. }
- W1869439357 endingPage "732" @default.
- W1869439357 startingPage "723" @default.
- W1869439357 abstract "Even though noradrenaline has been recognized as one of the key neurotransmitters in the pathophysiology of major depression (MD), noradrenergic compounds have been less extensively utilized in clinical practice, compared to selective serotonin reuptake inhibitors (SSRIs). The development of the first selective noradrenergic reuptake inhibitor (NRI), Reboxetine, has not substantially changed the state of the art. In addition, Atomoxetine, a relatively pure NRI used for the treatment of ADHD, has shown mixed results when administered in augmentation to depressed subjects. Through a Medline search from 2000 to 2010, the present article provides an updated overview of the main pharmacological and clinical aspects of antidepressant classes that, partially or selectively, act on the noradrenergic systems. The noradrenergic action plays an important clinical effect in different antidepressant classes, as confirmed by the efficacy of dual action antidepressants such as the serotonin noradrenaline reuptake inhibitors (SNRIs), the noradrenergic and dopaminergic reuptake inhibitor (NDRI) Bupropion, and other compounds (e.g., Mianserin, Mirtazapine), which enhance the noradrenergic transmission. In addition, many tricyclics, such as Desipramine and Nortriptyline, have prevalent noradrenergic effect. Monoamine oxidase inhibitors (MAOIs), moreover, block the breakdown of serotonin, noradrenaline, dopamine and increase the availability of these monoamines. A novel class of antidepressants--the triple reuptake inhibitors--is under development to selectively act on serotonin, noradrenaline, and dopamine. Finally, the antidepressant effect of the atypical antipsychotic Quetiapine, indicated for the treatment of bipolar depression, is likely to be related to the noradrenergic action of its metabolite Norquetiapine. Even though a pure noradrenergic action might not be sufficient to obtain a full antidepressant effect, a pronoradrenergic action represents an important element for increasing the efficacy of mixed action antidepressants. In particular, the noradrenergic action seemed to be related to the motor activity, attention, and arousal." @default.
- W1869439357 created "2016-06-24" @default.
- W1869439357 creator A5023394345 @default.
- W1869439357 creator A5037059287 @default.
- W1869439357 creator A5064949711 @default.
- W1869439357 creator A5089814310 @default.
- W1869439357 date "2010-12-14" @default.
- W1869439357 modified "2023-10-02" @default.
- W1869439357 title "The Noradrenergic Action in Antidepressant Treatments: Pharmacological and Clinical Aspects" @default.
- W1869439357 cites W1489185814 @default.
- W1869439357 cites W1530918435 @default.
- W1869439357 cites W1545716081 @default.
- W1869439357 cites W1935246010 @default.
- W1869439357 cites W1963689439 @default.
- W1869439357 cites W1966065460 @default.
- W1869439357 cites W1966637038 @default.
- W1869439357 cites W1971162866 @default.
- W1869439357 cites W1976275668 @default.
- W1869439357 cites W1979978856 @default.
- W1869439357 cites W1981363848 @default.
- W1869439357 cites W1982880546 @default.
- W1869439357 cites W1983082039 @default.
- W1869439357 cites W1987262076 @default.
- W1869439357 cites W1990217434 @default.
- W1869439357 cites W1992816731 @default.
- W1869439357 cites W1993628347 @default.
- W1869439357 cites W1999662659 @default.
- W1869439357 cites W2000187301 @default.
- W1869439357 cites W2000209756 @default.
- W1869439357 cites W2000591684 @default.
- W1869439357 cites W2006556233 @default.
- W1869439357 cites W2010152991 @default.
- W1869439357 cites W2011528345 @default.
- W1869439357 cites W2013447731 @default.
- W1869439357 cites W2014348686 @default.
- W1869439357 cites W2016577926 @default.
- W1869439357 cites W2017898544 @default.
- W1869439357 cites W2020855623 @default.
- W1869439357 cites W2021189780 @default.
- W1869439357 cites W2022148400 @default.
- W1869439357 cites W2026784040 @default.
- W1869439357 cites W2027109785 @default.
- W1869439357 cites W2027514689 @default.
- W1869439357 cites W2027986364 @default.
- W1869439357 cites W2028335215 @default.
- W1869439357 cites W2029009688 @default.
- W1869439357 cites W2029354175 @default.
- W1869439357 cites W2029503234 @default.
- W1869439357 cites W2034489605 @default.
- W1869439357 cites W2034529092 @default.
- W1869439357 cites W2039628081 @default.
- W1869439357 cites W2041948429 @default.
- W1869439357 cites W2047492413 @default.
- W1869439357 cites W2049361817 @default.
- W1869439357 cites W2053098983 @default.
- W1869439357 cites W2055459281 @default.
- W1869439357 cites W2058267296 @default.
- W1869439357 cites W2062005463 @default.
- W1869439357 cites W2062521625 @default.
- W1869439357 cites W2066454062 @default.
- W1869439357 cites W2067382805 @default.
- W1869439357 cites W2067998521 @default.
- W1869439357 cites W2068018732 @default.
- W1869439357 cites W2068822796 @default.
- W1869439357 cites W2069758270 @default.
- W1869439357 cites W2072219714 @default.
- W1869439357 cites W2076391934 @default.
- W1869439357 cites W2076981027 @default.
- W1869439357 cites W2078744556 @default.
- W1869439357 cites W2082010356 @default.
- W1869439357 cites W2082205780 @default.
- W1869439357 cites W2082914392 @default.
- W1869439357 cites W2083991574 @default.
- W1869439357 cites W2084578728 @default.
- W1869439357 cites W2085300561 @default.
- W1869439357 cites W2085578982 @default.
- W1869439357 cites W2085648354 @default.
- W1869439357 cites W2089052636 @default.
- W1869439357 cites W2089694151 @default.
- W1869439357 cites W2095586970 @default.
- W1869439357 cites W2096924058 @default.
- W1869439357 cites W2101801615 @default.
- W1869439357 cites W2103730699 @default.
- W1869439357 cites W2107786290 @default.
- W1869439357 cites W2108043630 @default.
- W1869439357 cites W2117459380 @default.
- W1869439357 cites W2120383646 @default.
- W1869439357 cites W2121086028 @default.
- W1869439357 cites W2121887640 @default.
- W1869439357 cites W2123795114 @default.
- W1869439357 cites W2126518605 @default.
- W1869439357 cites W2129953844 @default.
- W1869439357 cites W2132230262 @default.
- W1869439357 cites W2139600517 @default.
- W1869439357 cites W2146527338 @default.
- W1869439357 cites W2149154629 @default.
- W1869439357 cites W2157289463 @default.
- W1869439357 cites W2160344121 @default.