FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1869605310> ?p ?o ?g. }

• W1869605310 endingPage "1126" @default.
• W1869605310 startingPage "1125" @default.
• W1869605310 abstract "To the Editor: Malnutrition is a significant problem in elderly people. Up to 7% of community-dwelling and 8% to 45% of hospitalized elderly people are malnourished.1,2 The cause of malnutrition is usually multifactorial, including anorexia and increased energy expenditure during acute illness. Common comorbidities in elderly people, including hip fractures, heart failure, and obstructive pulmonary diseases, are associated with an increase in energy expenditure,3,4 which may contribute to weight loss. The sympathetic nervous system (SNS) is an important regulator of energy expenditure and substrate use. Sympathetic blockade using β-blockers in patients with head trauma and severe burns antagonizes catecholamine-induced tissue catabolism,5,6 although the effect of β-blockade on weight loss in hospitalized elderly patients has not been examined. The aim of this study was to determine whether β-blocker use influences weight change during hospital admission in elderly patients. A cross-sectional evaluation of anthropometric data was undertaken in 47 consecutive elderly patients admitted to the geriatrics ward at St. Vincent's Hospital, Sydney, Australia, between January and March 2008. Anthropometric measurements were repeated over 1 week of hospitalization on days 3 and 7. Patients with diabetes mellitus; organ transplants; severe cardiac, renal, or hepatic impairment; fever; or significant infection and patients taking corticosteroids or antipsychotic medications were excluded. Body weight and height were measured in hospital gowns on the same electronic scale. Body mass index (BMI) was calculated as body weight in kilograms divided by the square of height in meters. The Human Research Ethics Committee, St. Vincent's Hospital, approved the study. Verbal consent was obtained from patients for anthropometric measurements. Twenty-two (46.8%) of the 47 inpatients (mean age 83.2±6.0) were treated with β-blockers. All patients had been taking selective β1-blockers (atenolol 84.8%, metoprolol 15.2%) for at least 3 years. Most common causes for admission were falls (66.8%), delirium (55.2%), and progressive debility (48.0%). Frequency of diagnoses, blood pressure, and the number of medications taken by patients on admission were similar in β-blocker users and nonusers (data not shown). Admission body weight (60.2±0.4 kg/m2 vs 58.9±0.5 kg/m2, P=.4) and BMI (23.8±3.2 kg/m2 vs 22.6±3.9 kg/m2, P=.09) were not significantly different in β-blocker users and nonusers. BMI was less than 22 kg/m2 in 43%. Pulse rate was significantly lower in β-blocker users (69±10 vs 83±12 beats/min, P<.001), suggesting adequate medication adherence. During the 1-week follow-up, β-blocker nonusers lost weight, whereas users maintained their admission weight (Figure 1). The change in body weight was significantly greater in β-blocker nonusers than users by day 3 (−1.2±0.7 vs −0.1±0.9 kg, P=.004) and day 7 (−2.1±1.2 vs −0.2±1.1 kg, P<.001). Forward stepwise multiple regression was performed to determine the contribution of age, sex, blood pressure, pulse rate, and antihypertensive medication use to body weight reduction. In this model, β-blocker use was the only variable associated with weight change over the 1-week period (adjusted coefficient of variation=0.43, P<.001). Change in body weight at days 3 and 7 (β-blocker user=22, nonuser=25) (data are means±standard errors). The current study revealed a clinically significant weight-maintaining effect of β-blockers in geriatric patients, evident within 1 week of hospitalization. This study has potential clinical importance, given the high rates of malnutrition in elderly hospitalized patients.1,2 In one study, more than 50% of elderly hospitalized patients had a BMI less than 22 kg/m2.7 In another, approximately 1 kg of weight loss accompanied every week of hospitalization.2 Malnutrition is associated with adverse hospital and postdischarge clinical outcomes, including longer length of stay, higher rates of minor and major complications and mortality, and higher costs.1–4,7 The mechanisms that contribute to a possible effect of β-blockers on weight and body fat remain unknown. SNS activation has been shown to be an important inhibitor of food intake in rodents.8 Inhibition of the SNS using β-blockers would then be expected to stimulate food intake. In addition, SNS inhibition by β-blockers may reduce weight loss in hospitalized patients through a concomitant reduction in energy expenditure and stress-induced lipolysis.9 Although these metabolic changes would be detrimental in obese patients using β-blockers in the treatment of hypertension, they may be beneficial in elderly patients for the maintenance of body weight. The current study may have significant clinical implications. Therapeutic interventions for weight loss are limited in the elderly population. Adherence to nutritional supplements is generally poor.10 Although the cross-sectional design of the current study cannot establish causality, the observation of a rapid divergence in weight within 1 week of hospitalization suggests that short-term β-blocker therapy may have a beneficial role in weight maintenance in elderly hospitalized patients. Further research is required to investigate the role of short-term β-blockade on energy balance in hospitalized elderly patients. Conflict of Interest: The editor in chief has reviewed the conflict of interest checklist provided by the authors and has determined that the authors have no financial or any other kind of personal conflicts with this paper. Paul Lee was supported by a scholarship from the National Health and Medical Research Council, Australia. Author Contributions: Study concept and design: PL, JG, KH. Acquisition of subjects and data: PL. Analysis and interpretation of data: PL, JG, RD, KH. Preparation of manuscript: PL. Critical review of manuscript: PL, JG, RD, KH. Sponsor's Role: None." @default.
• W1869605310 created "2016-06-24" @default.
• W1869605310 creator A5001212969 @default.
• W1869605310 creator A5050397488 @default.
• W1869605310 creator A5057694040 @default.
• W1869605310 creator A5067007569 @default.
• W1869605310 date "2009-06-01" @default.
• W1869605310 modified "2023-09-27" @default.
• W1869605310 title "WEIGHT MAINTENANCE IN HOSPITALIZED GERIATRIC PATIENTS TREATED WITH BETA-BLOCKERS" @default.
• W1869605310 cites W1561688156 @default.
• W1869605310 cites W184534369 @default.
• W1869605310 cites W1975909301 @default.
• W1869605310 cites W2036116757 @default.
• W1869605310 cites W2075563350 @default.
• W1869605310 cites W2088631845 @default.
• W1869605310 cites W2095803642 @default.
• W1869605310 doi "https://doi.org/10.1111/j.1532-5415.2009.02282.x" @default.
• W1869605310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19490254" @default.
• W1869605310 hasPublicationYear "2009" @default.
• W1869605310 type Work @default.
• W1869605310 sameAs 1869605310 @default.
• W1869605310 citedByCount "0" @default.
• W1869605310 crossrefType "journal-article" @default.
• W1869605310 hasAuthorship W1869605310A5001212969 @default.
• W1869605310 hasAuthorship W1869605310A5050397488 @default.
• W1869605310 hasAuthorship W1869605310A5057694040 @default.
• W1869605310 hasAuthorship W1869605310A5067007569 @default.
• W1869605310 hasBestOaLocation W18696053101 @default.
• W1869605310 hasConcept C118552586 @default.
• W1869605310 hasConcept C126322002 @default.
• W1869605310 hasConcept C134018914 @default.
• W1869605310 hasConcept C1862650 @default.
• W1869605310 hasConcept C187212893 @default.
• W1869605310 hasConcept C2778198053 @default.
• W1869605310 hasConcept C2780221984 @default.
• W1869605310 hasConcept C511355011 @default.
• W1869605310 hasConcept C54183767 @default.
• W1869605310 hasConcept C544821477 @default.
• W1869605310 hasConcept C551997983 @default.
• W1869605310 hasConcept C555293320 @default.
• W1869605310 hasConcept C61427482 @default.
• W1869605310 hasConcept C71924100 @default.
• W1869605310 hasConceptScore W1869605310C118552586 @default.
• W1869605310 hasConceptScore W1869605310C126322002 @default.
• W1869605310 hasConceptScore W1869605310C134018914 @default.
• W1869605310 hasConceptScore W1869605310C1862650 @default.
• W1869605310 hasConceptScore W1869605310C187212893 @default.
• W1869605310 hasConceptScore W1869605310C2778198053 @default.
• W1869605310 hasConceptScore W1869605310C2780221984 @default.
• W1869605310 hasConceptScore W1869605310C511355011 @default.
• W1869605310 hasConceptScore W1869605310C54183767 @default.
• W1869605310 hasConceptScore W1869605310C544821477 @default.
• W1869605310 hasConceptScore W1869605310C551997983 @default.
• W1869605310 hasConceptScore W1869605310C555293320 @default.
• W1869605310 hasConceptScore W1869605310C61427482 @default.
• W1869605310 hasConceptScore W1869605310C71924100 @default.
• W1869605310 hasIssue "6" @default.
• W1869605310 hasLocation W18696053101 @default.
• W1869605310 hasLocation W18696053102 @default.
• W1869605310 hasOpenAccess W1869605310 @default.
• W1869605310 hasPrimaryLocation W18696053101 @default.
• W1869605310 hasRelatedWork W2006703431 @default.
• W1869605310 hasRelatedWork W2009350924 @default.
• W1869605310 hasRelatedWork W2026148549 @default.
• W1869605310 hasRelatedWork W2035019394 @default.
• W1869605310 hasRelatedWork W2137979777 @default.
• W1869605310 hasRelatedWork W2141893368 @default.
• W1869605310 hasRelatedWork W2510704414 @default.
• W1869605310 hasRelatedWork W2610149077 @default.
• W1869605310 hasRelatedWork W3096614328 @default.
• W1869605310 hasRelatedWork W4294775293 @default.
• W1869605310 hasVolume "57" @default.
• W1869605310 isParatext "false" @default.
• W1869605310 isRetracted "false" @default.
• W1869605310 magId "1869605310" @default.
• W1869605310 workType "article" @default.