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• W1869794329 abstract "The purpose of this study was to determine whether 4-chloro-m-cresol (4-CmC) could generate caffeine-like responses in ferret cardiac muscle. The concentration dependence of 4-CmC-mediated release of Ca(2+) from the sarcoplasmic reticulum was studied in intact cardiac trabeculae and saponin-skinned fibers in which the sarcoplasmic reticulum was loaded with Ca(2+). In intact and saponin-skinned preparations isolated from right ventricle, the effect of 4-CmC on sarcoplasmic reticulum Ca(2+) content was estimated by analysis of caffeine contracture after application of chlorocresol. In addition, the effects of 4-CmC on maximal Ca(2+)-activated tension and the Ca(2+) sensitivity of myofibrils were analyzed by using Triton-skinned cardiac fibers. The results show that 4-CmC generates a contractile response in saponin-skinned but not intact fibers. The sarcoplasmic reticulum is implicated in the 4-CmC response; more precisely, in Ca(2+) release via the ryanodine receptor. Moreover, 4-CmC, like caffeine, has effects on maximal Ca(2+)-activated tension and the Ca(2+) sensitivity of myofibrils." @default.
• W1869794329 created "2016-06-24" @default.
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• W1869794329 date "1999-08-01" @default.
• W1869794329 modified "2023-09-27" @default.
• W1869794329 title "Sarcoplasmic reticulum Ca(2+) release by 4-chloro-m-cresol (4-CmC) in intact and chemically skinned ferret cardiac ventricular fibers." @default.
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