Matches in SemOpenAlex for { <https://semopenalex.org/work/W1870060400> ?p ?o ?g. }
- W1870060400 endingPage "86" @default.
- W1870060400 startingPage "277" @default.
- W1870060400 abstract "Biodistribution and pharmacokinetics of radiolabeled mAb E48 IgG and E48 F(ab')2 were analyzed and compared in 39 patients with histologically proven squamous cell carcinoma of the head and neck who were included in a radioimmunoscintigraphy study and underwent surgery 44 h after injection. Three groups of patients were distinguished: group 1 (n = 19) received technetium-99m (99mTc)-labeled E48 F(ab')2, group 2 (n = 9) received 99mTc-labeled E48 IgG, and group 3 (n = 11) received 99mTc- and 131I-labeled E48 IgG as well as 125I-labeled F(ab')2. Two patients in group 1 and four patients in group 3 received a high mAb dose (10-50 mg), while all other patients received a low mAb dose (1-4 mg). From all patients in groups 2 and 3 biopsies from the surgical specimen were obtained 44 h postinjection. Tumor uptake of 99mTc-labeled E48 IgG was high, ranging from 0.007 to 0.082% of the injected dose/g, with a mean of 0.031 +/- 0.020% of the injected dose/g. The mean tumor:nontumor ratio of this conjugate was 2.8 for mucosa, 4.6 for bone marrow aspirate, 4.1 for blood, 20.3 for fat, and 21.0 for muscle. Activity uptake in tumor positive lymph nodes was 4.7 times higher as compared to negative lymph nodes. Sixteen h postinjection radioimmunoscintigraphy revealed activity uptake in the primary tumor, lymph node metastases, oral cavity, and adrenal glands. Using regions of interest, the uptake in the adrenal glands was estimated to be 0.050% of the injected dose/g. If a high mAb dose was used, no adrenal glands were visualized and the uptake in the oral cavity was clearly diminished, while the tumor uptake and tumor:nontumor ratios were increased. The mean elimination half-lifes t1/2 alpha and t1/2 in plasma were: for E48 IgG (n = 20) 6.6 +/- 2.6 and 54.1 +/- 24.3 h and for E48 F(ab')2 (n = 19) 2.3 +/- 0.4 and 19.9 +/- 4.6 h, respectively. Tumor uptake of 131I-labeled E48 IgG was 49% higher than of 125I-labeled F(ab')2. For most tissues except normal oral mucosa, tumor:nontumor ratios were slightly higher for F(ab')2 than for IgG. The present study shows that mAb E48 accumulates selectively and to a high level in head and neck squamous cell carcinoma. Although no definite conclusions can be drawn as to which mAb form is more suitable, IgG or F(ab')2, mAb E48 seems to have potential for radioimmunotherapy in head and neck squamous cell carcinoma patients." @default.
- W1870060400 created "2016-06-24" @default.
- W1870060400 creator A5016972795 @default.
- W1870060400 creator A5017269997 @default.
- W1870060400 creator A5042792515 @default.
- W1870060400 creator A5055466394 @default.
- W1870060400 creator A5068383329 @default.
- W1870060400 creator A5087396120 @default.
- W1870060400 creator A5089106956 @default.
- W1870060400 creator A5090151438 @default.
- W1870060400 date "1995-03-01" @default.
- W1870060400 modified "2023-09-23" @default.
- W1870060400 title "Biodistribution of radiolabeled monoclonal antibody E48 IgG and F(ab')2 in patients with head and neck cancer." @default.
- W1870060400 cites W1536690700 @default.
- W1870060400 cites W1566260450 @default.
- W1870060400 cites W1851719839 @default.
- W1870060400 cites W1924410298 @default.
- W1870060400 cites W1940241583 @default.
- W1870060400 cites W2025176178 @default.
- W1870060400 cites W2036838559 @default.
- W1870060400 cites W2041011104 @default.
- W1870060400 cites W2048089152 @default.
- W1870060400 cites W2068006908 @default.
- W1870060400 cites W2073256585 @default.
- W1870060400 cites W2101515095 @default.
- W1870060400 cites W2104081719 @default.
- W1870060400 cites W2119258963 @default.
- W1870060400 cites W2120796071 @default.
- W1870060400 cites W2127723419 @default.
- W1870060400 cites W2132668316 @default.
- W1870060400 cites W2141583201 @default.
- W1870060400 cites W2149612540 @default.
- W1870060400 cites W2150222896 @default.
- W1870060400 cites W2223135592 @default.
- W1870060400 cites W2288338386 @default.
- W1870060400 cites W2294180073 @default.
- W1870060400 cites W2327310363 @default.
- W1870060400 cites W2339732421 @default.
- W1870060400 cites W2406213538 @default.
- W1870060400 cites W2411538198 @default.
- W1870060400 cites W2461174185 @default.
- W1870060400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9815983" @default.
- W1870060400 hasPublicationYear "1995" @default.
- W1870060400 type Work @default.
- W1870060400 sameAs 1870060400 @default.
- W1870060400 citedByCount "11" @default.
- W1870060400 countsByYear W18700604002015 @default.
- W1870060400 crossrefType "journal-article" @default.
- W1870060400 hasAuthorship W1870060400A5016972795 @default.
- W1870060400 hasAuthorship W1870060400A5017269997 @default.
- W1870060400 hasAuthorship W1870060400A5042792515 @default.
- W1870060400 hasAuthorship W1870060400A5055466394 @default.
- W1870060400 hasAuthorship W1870060400A5068383329 @default.
- W1870060400 hasAuthorship W1870060400A5087396120 @default.
- W1870060400 hasAuthorship W1870060400A5089106956 @default.
- W1870060400 hasAuthorship W1870060400A5090151438 @default.
- W1870060400 hasConcept C112705442 @default.
- W1870060400 hasConcept C121608353 @default.
- W1870060400 hasConcept C126322002 @default.
- W1870060400 hasConcept C142724271 @default.
- W1870060400 hasConcept C150903083 @default.
- W1870060400 hasConcept C159654299 @default.
- W1870060400 hasConcept C203014093 @default.
- W1870060400 hasConcept C207001950 @default.
- W1870060400 hasConcept C2777546739 @default.
- W1870060400 hasConcept C2777807558 @default.
- W1870060400 hasConcept C2779720271 @default.
- W1870060400 hasConcept C2780849966 @default.
- W1870060400 hasConcept C2994460389 @default.
- W1870060400 hasConcept C542903549 @default.
- W1870060400 hasConcept C71924100 @default.
- W1870060400 hasConcept C86803240 @default.
- W1870060400 hasConceptScore W1870060400C112705442 @default.
- W1870060400 hasConceptScore W1870060400C121608353 @default.
- W1870060400 hasConceptScore W1870060400C126322002 @default.
- W1870060400 hasConceptScore W1870060400C142724271 @default.
- W1870060400 hasConceptScore W1870060400C150903083 @default.
- W1870060400 hasConceptScore W1870060400C159654299 @default.
- W1870060400 hasConceptScore W1870060400C203014093 @default.
- W1870060400 hasConceptScore W1870060400C207001950 @default.
- W1870060400 hasConceptScore W1870060400C2777546739 @default.
- W1870060400 hasConceptScore W1870060400C2777807558 @default.
- W1870060400 hasConceptScore W1870060400C2779720271 @default.
- W1870060400 hasConceptScore W1870060400C2780849966 @default.
- W1870060400 hasConceptScore W1870060400C2994460389 @default.
- W1870060400 hasConceptScore W1870060400C542903549 @default.
- W1870060400 hasConceptScore W1870060400C71924100 @default.
- W1870060400 hasConceptScore W1870060400C86803240 @default.
- W1870060400 hasIssue "3" @default.
- W1870060400 hasLocation W18700604001 @default.
- W1870060400 hasOpenAccess W1870060400 @default.
- W1870060400 hasPrimaryLocation W18700604001 @default.
- W1870060400 hasRelatedWork W1803114945 @default.
- W1870060400 hasRelatedWork W1963761640 @default.
- W1870060400 hasRelatedWork W1978620074 @default.
- W1870060400 hasRelatedWork W2143552779 @default.
- W1870060400 hasRelatedWork W2149729010 @default.
- W1870060400 hasRelatedWork W2168635148 @default.