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- W1870364570 abstract "The present study evaluated the contribution of cytochrome P-450 ω-hydroxylase in modulating the reactivity of cremaster muscle arterioles in normotensive rats on high-salt (HS) and low-salt (LS) diet and in rats with reduced renal mass hypertension (RRM-HT). Changes in arteriolar diameter in response to ACh, sodium nitroprusside (SNP), ANG II, and elevated O 2 were measured via television microscopy under control conditions and following cytochrome P-450 ω-hydroxylase inhibition with 17-octadecynoic acid (17-ODYA) or N-methylsulfonyl-12,12-dibromododec-11-enamide (DDMS). In normotensive rats on either LS or HS diet, resting tone was unaffected and arteriolar reactivity to ACh or SNP was minimally affected by cytochrome P-450 ω-hydroxylase inhibition. In RRM-HT rats, cytochrome P-450 ω-hydroxylase inhibition reduced resting tone and significantly enhanced arteriolar dilation to ACh and SNP. Treatment with 17-ODYA or DDMS inhibited arteriolar constriction to ANG II and O 2 in all the groups, although the degree of inhibition was greater in RRM-HT than in normotensive animals. These results suggest that metabolites of cytochrome P-450 ω-hydroxylase contribute to the altered reactivity of skeletal muscle arterioles to vasoconstrictor and vasodilator stimuli in RRM-HT." @default.
- W1870364570 created "2016-06-24" @default.
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- W1870364570 date "2000-05-01" @default.
- W1870364570 modified "2023-10-15" @default.
- W1870364570 title "Contribution of cytochrome <i>P</i>-450 ω-hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension" @default.
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- W1870364570 doi "https://doi.org/10.1152/ajpheart.2000.278.5.h1517" @default.
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