Matches in SemOpenAlex for { <https://semopenalex.org/work/W18704998> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W18704998 endingPage "71" @default.
- W18704998 startingPage "265" @default.
- W18704998 abstract "We analyzed matched cerebrospinal fluid and blood samples from 139 subjects enrolled in a study of the effects of human immunodeficiency virus type 1 (HIV-1) on the nervous system. Mean total intrathecal IgG synthesis rate was significantly higher in subjects with HIV-1-related neurologic disease (NeuroPos) than in HIV-1-seropositive (HIV+) subjects without neurologic disease (NeuroNeg) or at-risk seronegative controls (SNC). Mean trans-blood-brain barrier (BBB) albumin leakage (AL) rate increased significantly across groups (SNC < NeuroNeg < NeuroPos). AL was significantly higher in subjects with absolute CD4 counts < 100/mm3 versus those with > or = 100 cells/mm3 and significantly higher in AIDS compared with asymptomatic HIV+. Elevated total intrathecal IgG synthesis rate could not be accounted for solely by the presence of a damaged BBB, because 79% of subjects with elevated IgG synthesis rates had a normal BBB as assessed by the AL formula. Furthermore, the Tourtellotte formula inherently corrects for BBB leakage. We confirmed, using state-of-the-art albumin and IgG determinations, that intrathecal IgG synthesis is prevalent in all stages of HIV-1 disease. In the absence of a CNS opportunistic infection or tumor, mean total intrathecal IgG synthesis rate and trans-BBB AL are significantly higher in subjects with clinical HIV-1 CNS disease than in neurologically normally HIV+ subjects." @default.
- W18704998 created "2016-06-24" @default.
- W18704998 creator A5016344996 @default.
- W18704998 creator A5018851947 @default.
- W18704998 creator A5032692520 @default.
- W18704998 creator A5055796203 @default.
- W18704998 creator A5055979372 @default.
- W18704998 creator A5089334841 @default.
- W18704998 date "1994-03-01" @default.
- W18704998 modified "2023-09-23" @default.
- W18704998 title "Intrathecal IgG synthesis and albumin leakage are increased in subjects with HIV-1 neurologic disease." @default.
- W18704998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7906304" @default.
- W18704998 hasPublicationYear "1994" @default.
- W18704998 type Work @default.
- W18704998 sameAs 18704998 @default.
- W18704998 citedByCount "15" @default.
- W18704998 countsByYear W187049982015 @default.
- W18704998 crossrefType "journal-article" @default.
- W18704998 hasAuthorship W18704998A5016344996 @default.
- W18704998 hasAuthorship W18704998A5018851947 @default.
- W18704998 hasAuthorship W18704998A5032692520 @default.
- W18704998 hasAuthorship W18704998A5055796203 @default.
- W18704998 hasAuthorship W18704998A5055979372 @default.
- W18704998 hasAuthorship W18704998A5089334841 @default.
- W18704998 hasConcept C126322002 @default.
- W18704998 hasConcept C157820659 @default.
- W18704998 hasConcept C165616093 @default.
- W18704998 hasConcept C203014093 @default.
- W18704998 hasConcept C2776125364 @default.
- W18704998 hasConcept C2777910003 @default.
- W18704998 hasConcept C2778402981 @default.
- W18704998 hasConcept C2779281540 @default.
- W18704998 hasConcept C2779651940 @default.
- W18704998 hasConcept C42219234 @default.
- W18704998 hasConcept C529278444 @default.
- W18704998 hasConcept C71924100 @default.
- W18704998 hasConcept C90924648 @default.
- W18704998 hasConceptScore W18704998C126322002 @default.
- W18704998 hasConceptScore W18704998C157820659 @default.
- W18704998 hasConceptScore W18704998C165616093 @default.
- W18704998 hasConceptScore W18704998C203014093 @default.
- W18704998 hasConceptScore W18704998C2776125364 @default.
- W18704998 hasConceptScore W18704998C2777910003 @default.
- W18704998 hasConceptScore W18704998C2778402981 @default.
- W18704998 hasConceptScore W18704998C2779281540 @default.
- W18704998 hasConceptScore W18704998C2779651940 @default.
- W18704998 hasConceptScore W18704998C42219234 @default.
- W18704998 hasConceptScore W18704998C529278444 @default.
- W18704998 hasConceptScore W18704998C71924100 @default.
- W18704998 hasConceptScore W18704998C90924648 @default.
- W18704998 hasIssue "3" @default.
- W18704998 hasLocation W187049981 @default.
- W18704998 hasOpenAccess W18704998 @default.
- W18704998 hasPrimaryLocation W187049981 @default.
- W18704998 hasRelatedWork W1554977340 @default.
- W18704998 hasRelatedWork W1589397612 @default.
- W18704998 hasRelatedWork W18704998 @default.
- W18704998 hasRelatedWork W1974160873 @default.
- W18704998 hasRelatedWork W1986443775 @default.
- W18704998 hasRelatedWork W2094321923 @default.
- W18704998 hasRelatedWork W2266467625 @default.
- W18704998 hasRelatedWork W2407574591 @default.
- W18704998 hasRelatedWork W2410701298 @default.
- W18704998 hasRelatedWork W2983538257 @default.
- W18704998 hasVolume "7" @default.
- W18704998 isParatext "false" @default.
- W18704998 isRetracted "false" @default.
- W18704998 magId "18704998" @default.
- W18704998 workType "article" @default.