Matches in SemOpenAlex for { <https://semopenalex.org/work/W1870558124> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W1870558124 startingPage "2339" @default.
- W1870558124 abstract "Asthma is a heterogeneous disease, not only in its clinical expression and course but also in its response to treatment with deleterious effects on Quality of life (QoL). Anti- IgE can spare these patients with unnecessary exacerbations and have a better QoL. The objective of this study was to evaluate the effectiveness of omalizumab treatment in improving QoL in patients with severe allergic rhinitis and asthma. Methods: 41 patients aged > 18 years with steroid-resistant asthma were enrolled in this open label study. Patients were examined at baseline and were treated with omalizumab administered subcutaneously every 2 or 4 weeks (at least 0.016 mg/kg/IgE IU/ml), in addition to existing treatment. At both visits, investigators assessed QoL on a 4 point scale in the following domains: nasal, ocular and asthmatic symptoms. Scores were calculated for individual symptoms, total scores for each domain. Patients were also assessed on impairment of sleep and daily activities. Results: Omalizumab significantly reduced scores from baseline in both nasal and ocular symptoms. Reductions were also seen in the asthmatic symptom scores: significance was noted in wheezing (P=0.0002) and breathless scores (P=0.0002). At baseline, 62 % of patients had some degree of daily activity impairment, whereas at the final visit only 31% had daily activity impairment. Similarly, while 55% of patients had some sleep impairment at baseline, this was reduced to 28% at the final visit. Conclusions: This open label study demonstrated that omalizumab was an effective treatment for the symptoms and sleep/daily life impairments associated with severe allergic rhinitis and asthma." @default.
- W1870558124 created "2016-06-24" @default.
- W1870558124 creator A5052005612 @default.
- W1870558124 creator A5064053675 @default.
- W1870558124 date "2012-09-01" @default.
- W1870558124 modified "2023-09-26" @default.
- W1870558124 title "Effectiveness of omalizumab in improving quality of life in patients with 'steroid-resistant' asthma and severe allergic rhinitis" @default.
- W1870558124 hasPublicationYear "2012" @default.
- W1870558124 type Work @default.
- W1870558124 sameAs 1870558124 @default.
- W1870558124 citedByCount "0" @default.
- W1870558124 crossrefType "journal-article" @default.
- W1870558124 hasAuthorship W1870558124A5052005612 @default.
- W1870558124 hasAuthorship W1870558124A5064053675 @default.
- W1870558124 hasConcept C126322002 @default.
- W1870558124 hasConcept C141105273 @default.
- W1870558124 hasConcept C159110408 @default.
- W1870558124 hasConcept C159654299 @default.
- W1870558124 hasConcept C1862650 @default.
- W1870558124 hasConcept C187212893 @default.
- W1870558124 hasConcept C203014093 @default.
- W1870558124 hasConcept C207480886 @default.
- W1870558124 hasConcept C2776042228 @default.
- W1870558124 hasConcept C2778564945 @default.
- W1870558124 hasConcept C2779951463 @default.
- W1870558124 hasConcept C71924100 @default.
- W1870558124 hasConceptScore W1870558124C126322002 @default.
- W1870558124 hasConceptScore W1870558124C141105273 @default.
- W1870558124 hasConceptScore W1870558124C159110408 @default.
- W1870558124 hasConceptScore W1870558124C159654299 @default.
- W1870558124 hasConceptScore W1870558124C1862650 @default.
- W1870558124 hasConceptScore W1870558124C187212893 @default.
- W1870558124 hasConceptScore W1870558124C203014093 @default.
- W1870558124 hasConceptScore W1870558124C207480886 @default.
- W1870558124 hasConceptScore W1870558124C2776042228 @default.
- W1870558124 hasConceptScore W1870558124C2778564945 @default.
- W1870558124 hasConceptScore W1870558124C2779951463 @default.
- W1870558124 hasConceptScore W1870558124C71924100 @default.
- W1870558124 hasOpenAccess W1870558124 @default.
- W1870558124 hasRelatedWork W2131945470 @default.
- W1870558124 hasRelatedWork W2394599586 @default.
- W1870558124 hasRelatedWork W2397424022 @default.
- W1870558124 hasRelatedWork W2532769566 @default.
- W1870558124 hasRelatedWork W2550157314 @default.
- W1870558124 hasRelatedWork W2556304753 @default.
- W1870558124 hasRelatedWork W2617429985 @default.
- W1870558124 hasRelatedWork W2767863134 @default.
- W1870558124 hasRelatedWork W2778869526 @default.
- W1870558124 hasRelatedWork W2784312422 @default.
- W1870558124 hasRelatedWork W2791933168 @default.
- W1870558124 hasRelatedWork W2894920106 @default.
- W1870558124 hasRelatedWork W2991196696 @default.
- W1870558124 hasRelatedWork W3022195529 @default.
- W1870558124 hasRelatedWork W3023673104 @default.
- W1870558124 hasRelatedWork W3109667984 @default.
- W1870558124 hasRelatedWork W3111332292 @default.
- W1870558124 hasRelatedWork W3171092434 @default.
- W1870558124 hasRelatedWork W3193012657 @default.
- W1870558124 hasRelatedWork W3195546789 @default.
- W1870558124 hasVolume "40" @default.
- W1870558124 isParatext "false" @default.
- W1870558124 isRetracted "false" @default.
- W1870558124 magId "1870558124" @default.
- W1870558124 workType "article" @default.