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- W1870584700 abstract "Background and aim : The aim of study was to assess the oxidative status in rat hepatic and renal tissues after intraperitoneal administration of acetaminophen (AP) versus lornoxicam (L). Materials and Methods : For this purpose 18 Wistar Albino rats were randomly divided into 3 groups; each group consists of 6 rats. Group Control (Group C) remain untreated, comprises healthy rats. Group AP received AP (100 mg kg -1 ) and Group L received L (1.3 mg kg -1 ) intraperitoneally. Oxidative status was evaluated by MDA, SOD, GST and CAT in hepatic and renal tissues. Furthermore histopathalogical evaluation was performed in both tissues. Results : The lornoxicam received rats (Group L) showed significantly increased level of MDA and GST [(p=0.015), (p=0.048) respectively],decreased level of SOD (p=0.02)in liver tissue. Renal tissue MDA, SOD and GST activity and CAT levels were similar in groups [(p=0.168), (p=0.270), (p=0.686) respectively]. Histopathalogically Group AP and Group L more damaged than in Group C. Hepatic injury was moderate level in two groups. Minimal injury was observed in group AP. Renal injury in group L more than the Group AP. Conclusion : The results suggest that hepatotoxic effects of lornoxicam more than the AP while no remarkable difference nephrotoxicity." @default.
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- W1870584700 date "2015-04-07" @default.
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- W1870584700 title "Effect of Acetaminofen Versus Lornoxicam Admistration on Oxidative Stress in Rat Hepatic and Renal Tissues" @default.
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- W1870584700 doi "https://doi.org/10.17546/msd.71259" @default.
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