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• W1870661610 abstract "Publisher Summary This chapter deals with the structure and function of the leader transcript of human immunodeficiency virus (HIV-1) and HIV-2. Most of the RNA signals encoded by the untranslated leader RNA have specific nucleotide sequences critical for recognition and function, but there is accumulating evidence that their structural context can also be important. There is an intense effort to analyze the secondary structure of retroviral leader RNAs using a variety of methods, including biochemical analysis, free-energy minimization, sequence comparison, and mutant analysis. The chapter focuses primarily on the relationships between the structure of specific leader RNA motifs and their function in the retroviral life cycle. Among retroviruses, the lentiviruses have the most complex genome structure and expression strategy. The primate lentiviruses include the human and simian immunodeficiency viruses (SIV). Understanding the three-dimensional structure formed by the HIV leader RNA molecule, both free and in the ribonucleoprotein complex of virion, is crucial for analyzing its specific recognition by proteins and its interaction by other RNA molecules during virus replication. The number of HIV–SIV sequences now known is sufficiently large; hence, comparative analysis can be used effectively to deduce some of the basic design principles underlying HIV RNA structure. By understanding the molecular basis of the interactions that govern critical steps in the retroviral replication cycle, it may be possible to develop methods to intervene therapeutically in the process." @default.
• W1870661610 created "2016-06-24" @default.
• W1870661610 creator A5015784090 @default.
• W1870661610 date "1996-01-01" @default.
• W1870661610 modified "2023-10-14" @default.
• W1870661610 title "Structure and Function of the Human Immunodeficiency Virus Leader RNA" @default.
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