Matches in SemOpenAlex for { <https://semopenalex.org/work/W1870739445> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1870739445 startingPage "2047" @default.
- W1870739445 abstract "Purpose: Metabonomics is a well-developed platform for studying systems biology and clinical diagnosis. In this study, we investigated a metabonomic approach to prognostic evaluation of LPS-induced ALI by HR NMR spectroscopy. Methods: The mice model of ALI was established by intratracheal instillation of LPS (5mg/kg) for 4 hours with the saline in control mice. The mice of dexamethasone (DEX) treatment group were intraperitoneally treated with DEX while intratracheal instillation of LPS. HR 1 H NMR spectroscopy in combination with pattern recognition methods was applied to study 15 lung tissues extract samples of mice. Results: The lung injury score were significantly increased in ALI mice compared to control group and DEX treatment markedly decreased the lung injury score. The first principal component (PC1) shows a good separation between the ALI group and control (or DEX treatment) groups. The metabolites showed clear differentiation between groups mainly included valine (Val, δ 1.06), lactate (Lac, δ 1.33), acetate (Ace, δ 1.91), creatine (Cre, δ 3.06). In addition, these samples in the ALI group clearly located out of other groups, and four of five samples in the DEX treatment group fell in the range of the control group. Conclusions: Our study, for the first time, provides evidence for a metabonomic approach to prognostic evaluation of ALI treated with DEX by HR NMR spectroscopy." @default.
- W1870739445 created "2016-06-24" @default.
- W1870739445 creator A5010804247 @default.
- W1870739445 creator A5024974078 @default.
- W1870739445 creator A5034159418 @default.
- W1870739445 creator A5042844951 @default.
- W1870739445 creator A5071595868 @default.
- W1870739445 creator A5074082072 @default.
- W1870739445 date "2011-09-01" @default.
- W1870739445 modified "2023-09-24" @default.
- W1870739445 title "A metabonomic approach to prognostic evaluation of ALI by high-resolution nuclear magnetic resonance (HR NMR) spectroscopy" @default.
- W1870739445 hasPublicationYear "2011" @default.
- W1870739445 type Work @default.
- W1870739445 sameAs 1870739445 @default.
- W1870739445 citedByCount "0" @default.
- W1870739445 crossrefType "journal-article" @default.
- W1870739445 hasAuthorship W1870739445A5010804247 @default.
- W1870739445 hasAuthorship W1870739445A5024974078 @default.
- W1870739445 hasAuthorship W1870739445A5034159418 @default.
- W1870739445 hasAuthorship W1870739445A5042844951 @default.
- W1870739445 hasAuthorship W1870739445A5071595868 @default.
- W1870739445 hasAuthorship W1870739445A5074082072 @default.
- W1870739445 hasConcept C126322002 @default.
- W1870739445 hasConcept C185592680 @default.
- W1870739445 hasConcept C2777397205 @default.
- W1870739445 hasConcept C2777573094 @default.
- W1870739445 hasConcept C2777714996 @default.
- W1870739445 hasConcept C2779896295 @default.
- W1870739445 hasConcept C2780401358 @default.
- W1870739445 hasConcept C515207424 @default.
- W1870739445 hasConcept C55493867 @default.
- W1870739445 hasConcept C66974803 @default.
- W1870739445 hasConcept C71240020 @default.
- W1870739445 hasConcept C71924100 @default.
- W1870739445 hasConcept C98274493 @default.
- W1870739445 hasConceptScore W1870739445C126322002 @default.
- W1870739445 hasConceptScore W1870739445C185592680 @default.
- W1870739445 hasConceptScore W1870739445C2777397205 @default.
- W1870739445 hasConceptScore W1870739445C2777573094 @default.
- W1870739445 hasConceptScore W1870739445C2777714996 @default.
- W1870739445 hasConceptScore W1870739445C2779896295 @default.
- W1870739445 hasConceptScore W1870739445C2780401358 @default.
- W1870739445 hasConceptScore W1870739445C515207424 @default.
- W1870739445 hasConceptScore W1870739445C55493867 @default.
- W1870739445 hasConceptScore W1870739445C66974803 @default.
- W1870739445 hasConceptScore W1870739445C71240020 @default.
- W1870739445 hasConceptScore W1870739445C71924100 @default.
- W1870739445 hasConceptScore W1870739445C98274493 @default.
- W1870739445 hasLocation W18707394451 @default.
- W1870739445 hasOpenAccess W1870739445 @default.
- W1870739445 hasPrimaryLocation W18707394451 @default.
- W1870739445 hasRelatedWork W2089730728 @default.
- W1870739445 hasRelatedWork W2344885752 @default.
- W1870739445 hasRelatedWork W2360648730 @default.
- W1870739445 hasRelatedWork W2369221301 @default.
- W1870739445 hasRelatedWork W2371130897 @default.
- W1870739445 hasRelatedWork W2379031216 @default.
- W1870739445 hasRelatedWork W2381741075 @default.
- W1870739445 hasRelatedWork W2382302635 @default.
- W1870739445 hasRelatedWork W2384657461 @default.
- W1870739445 hasRelatedWork W2392905167 @default.
- W1870739445 hasRelatedWork W2394350733 @default.
- W1870739445 hasRelatedWork W2398953444 @default.
- W1870739445 hasRelatedWork W2418718556 @default.
- W1870739445 hasRelatedWork W2980353081 @default.
- W1870739445 hasRelatedWork W3028893628 @default.
- W1870739445 hasRelatedWork W3029337766 @default.
- W1870739445 hasRelatedWork W3030507984 @default.
- W1870739445 hasRelatedWork W3031506213 @default.
- W1870739445 hasRelatedWork W3031842097 @default.
- W1870739445 hasRelatedWork W3032079489 @default.
- W1870739445 hasVolume "38" @default.
- W1870739445 isParatext "false" @default.
- W1870739445 isRetracted "false" @default.
- W1870739445 magId "1870739445" @default.
- W1870739445 workType "article" @default.