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• W1871307580 abstract "Objective To analyse the immunohistochemical and mRNA expression of SWI / SNF ( SWI tch/ S ucrose N on F ermentable) complex subunit polybromo‐1 ( PBRM 1) in clear cell renal cell carcinoma ( ccRCC ) and its impact on clinical outcomes. Patients and Methods In all, 213 consecutive patients treated surgically for renal cell carcinoma (RCC) between 1992 and 2009 were selected. A single pathologist reviewed all cases to effect a uniform reclassification and determined the most representative tumour areas for construction of a tissue microarray. In addition, mRNA expression of PBRM 1 was analysed by reverse transcriptase‐polymerase chain reaction. Results Of the 112‐immunostained ccRCC specimens, 34 (30.4%) were PBRM 1‐negative, and 78 (69.6%) were PBRM 1‐positive. The protein expression of PBRM 1 was associated with tumour stage ( P < 0.001), clinical stage ( P < 0.001), pN stage ( P = 0.035) and tumour size ( P = 0.002). PBRM 1 mRNA expression was associated with clinical stage ( P = 0.023), perinephric fat invasion ( P = 0.008) and lymphovascular invasion ( P = 0.042). PBRM 1 significantly influenced tumour recurrence and tumour‐related death. Disease‐specific survival rates for patients whose specimens showed positive‐ and negative‐ PBRM 1 expression were 89.7% and 70.6%, respectively ( P = 0.017). Recurrence‐free survival rates in patients with positive‐ and negative‐expression of PBRM 1 were 87.3% and 66.7%, respectively ( P = 0.048). Conclusions PBRM 1‐negative expression is a markedly poor prognosis event in ccRCC . We encourage PBRM 1 study by other groups in order to validate our findings and confirm its possible role as a useful marker in the management of patients with ccRCC ." @default.
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• W1871307580 date "2013-12-02" @default.
• W1871307580 modified "2023-09-27" @default.
• W1871307580 title "Polybromo-1 (PBRM1), a SWI/SNF complex subunit is a prognostic marker in clear cell renal cell carcinoma" @default.
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• W1871307580 doi "https://doi.org/10.1111/bju.12426" @default.
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