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- W1871478100 abstract "Significance Evoked synaptic transmission is mediated by synchronous and asynchronous phases of neurotransmitter release. Synaptotagmin 1 (syt1) serves as the Ca 2+ sensor for synchronous release. Recently, we proposed that double C2-like domain-containing protein alpha and beta (Doc2α and Doc2β), cytosolic proteins with tandem C2 domains homologous to syt1, function as Ca 2+ sensors for asynchronous release, but this idea remains controversial. Here, we systematically analyzed the functional significance of each Ca 2+ ligand in Doc2β and found a correlation between the Ca 2+ -dependent translocation activity of these mutants (to the plasma membrane) and changes in asynchronous release. Moreover, we show that syt1–Doc2β chimeras exhibit altered kinetics in vitro and change the rates of synaptic transmission in cultured neurons. These results establish Doc2β as a Ca 2+ sensor for the slow phase of neurotransmission." @default.
- W1871478100 created "2016-06-24" @default.
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- W1871478100 date "2015-07-20" @default.
- W1871478100 modified "2023-10-15" @default.
- W1871478100 title "Structural elements that underlie Doc2β function during asynchronous synaptic transmission" @default.
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- W1871478100 doi "https://doi.org/10.1073/pnas.1502288112" @default.
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