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- W1871567418 abstract "This chapter discusses the determination of α-hydroxyethylthiamine diphosphate (HETDP) and α,β -dihydroxyethylthiamine diphosphate (diHETDP). In the method of preparation of α-hydroxyethylthiamine diphosphate, it is found that under slightly alkaline conditions thiamine or thiamine diphosphate catalyzes the nonenzymatic conversion of pyruvate to acetoin. Acetaldehyde is also converted to acetoin, although at a somewhat slower rate. Following the proposal that carbon atom 2 of the thiazolium ring of thiamine is involved in the catalysis, the presence of α-hydroxyethylthiamine as an intermediate in the nonenzymatic system was sought. Comparison of the intermediate with the authentic α-hydroxyethylthiamine obtained by synthesis was made. Under proper conditions α-hydroxyethylthiamine accumulates in this system to the extent of 30–40% of the amount of thiamine present. Employing thiamine diphosphate, comparable yields of α-hydroxyethylthiamine diphosphate can be obtained. In the method of preparation of α,β-dihydroxyethylthiamine diphosphate, analogy formaldehyde condensed with thiamine or thiamine diphosphate to form the hydroxymethyl adduct at position 2 of the thiazolium ring followed by a further condensation with another mole of formaldehyde forms α,β-dihydroxyethyl thiamine diphosphate." @default.
- W1871567418 created "2016-06-24" @default.
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- W1871567418 date "1966-01-01" @default.
- W1871567418 modified "2023-09-25" @default.
- W1871567418 title "[15] α-Hydroxyethylthiamine diphosphate and α,β-dihydroxyethylthiamine diphosphate" @default.
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- W1871567418 doi "https://doi.org/10.1016/0076-6879(66)09019-0" @default.
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