FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W187160821> ?p ?o ?g. }

• W187160821 endingPage "30" @default.
• W187160821 startingPage "23" @default.
• W187160821 abstract "Knowledge of folic acid and related factors present in the human circulatory system seems important from a fundamental point of view, and particularly because of the use of folic acid antimetabolites in experimental cancer therapy. Available data are fragmentary and conflicting, as is shown in condensed form by Table I. In Table I experiments involving the use of Taka-Diastase have been disregarded, since these results were shown to be meaningless because conjugases of the blood liberate folic acid from conjugates present in the enzyme preparation, rather than vice versa (3, 4). Our own earlier results (5), which were 5 to 10’ times as high as those reported by others, were obtained without the use of anticoagulants 01 extraneous enzyme preparations, and without removal of blood proteins, bacterial growth response being measured by titration rather than turbidimetrically, because of the presence of suspended protein. Further investigation was directed toward clarification of the factors responsible for the divergent results, specifically, the possible r61e of the presence of anticoagulants, the r&e of heat treatment (sterilization), and the r61e of the blood proteins. Experiments showed that different anticoagulants yield different results even though, in the concentrations used, they do not directly influence the growth of the assay organisms Lactobacillus casei and Streptococcus lactis R. A summary of these findings is included in Table I. It also became clear from these data that in the presence of blood prot,eins assay response is much higher than after their removal by precipitation. Because folic acid-active material may conceivably be lost by being adsorbed on or combined with blood proteins, the possibility of separating the active low molecular factors by dialysis was considered. It was decided, for the first phase of the investigation, not to attempt differentiation between blood cells and plasma nor to apply exogenous conjugase sources but merely to establish the conditions under which whole blood * Bacterimetric studies VIII. Aided by a fund in memory of Macmillan Hoopes. This investigation was also supported in part by a research grant from the National Cancer Institute of the National Institutes of Health, United States Public Health Service, and by an institutional research grant of the American Cancer Society. Presented at the Twelfth International Congress of Pure and Applied Chemistry (Section of Biological Chemistry), New York, September, 1951." @default.
• W187160821 created "2016-06-24" @default.
• W187160821 creator A5013566230 @default.
• W187160821 creator A5015264916 @default.
• W187160821 creator A5061327210 @default.
• W187160821 date "1953-01-01" @default.
• W187160821 modified "2023-10-16" @default.
• W187160821 title "On the Folic Acid Activity of Human Blood" @default.
• W187160821 cites W2172567611 @default.
• W187160821 cites W2207315933 @default.
• W187160821 cites W4675680 @default.
• W187160821 cites W81961644 @default.
• W187160821 doi "https://doi.org/10.1016/s0021-9258(18)38433-3" @default.
• W187160821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13034755" @default.
• W187160821 hasPublicationYear "1953" @default.
• W187160821 type Work @default.
• W187160821 sameAs 187160821 @default.
• W187160821 citedByCount "31" @default.
• W187160821 crossrefType "journal-article" @default.
• W187160821 hasAuthorship W187160821A5013566230 @default.
• W187160821 hasAuthorship W187160821A5015264916 @default.
• W187160821 hasAuthorship W187160821A5061327210 @default.
• W187160821 hasBestOaLocation W1871608211 @default.
• W187160821 hasConcept C126322002 @default.
• W187160821 hasConcept C185592680 @default.
• W187160821 hasConcept C2992130864 @default.
• W187160821 hasConcept C55493867 @default.
• W187160821 hasConcept C71924100 @default.
• W187160821 hasConceptScore W187160821C126322002 @default.
• W187160821 hasConceptScore W187160821C185592680 @default.
• W187160821 hasConceptScore W187160821C2992130864 @default.
• W187160821 hasConceptScore W187160821C55493867 @default.
• W187160821 hasConceptScore W187160821C71924100 @default.
• W187160821 hasIssue "1" @default.
• W187160821 hasLocation W1871608211 @default.
• W187160821 hasOpenAccess W187160821 @default.
• W187160821 hasPrimaryLocation W1871608211 @default.
• W187160821 hasRelatedWork W1531601525 @default.
• W187160821 hasRelatedWork W1990781990 @default.
• W187160821 hasRelatedWork W2384464875 @default.
• W187160821 hasRelatedWork W2606230654 @default.
• W187160821 hasRelatedWork W2607424097 @default.
• W187160821 hasRelatedWork W2748952813 @default.
• W187160821 hasRelatedWork W2760600600 @default.
• W187160821 hasRelatedWork W2899084033 @default.
• W187160821 hasRelatedWork W2948807893 @default.
• W187160821 hasRelatedWork W2778153218 @default.
• W187160821 hasVolume "200" @default.
• W187160821 isParatext "false" @default.
• W187160821 isRetracted "false" @default.
• W187160821 magId "187160821" @default.
• W187160821 workType "article" @default.