Matches in SemOpenAlex for { <https://semopenalex.org/work/W1871625715> ?p ?o ?g. }
- W1871625715 abstract "To examine the comparative fate of adipose-derived stem cells (ASCs) as well as their impact on coronary microcirculation following either retrograde coronary venous (RCV) or arterial delivery.Local delivery of ASCs to the heart has been proposed as a practical approach to limiting the extent of myocardial infarction. Mouse models of mesenchymal stem cell effects on the heart have also demonstrated significant benefits from systemic (intravenous) delivery, prompting a question about the advantage of local delivery. There has been no study addressing the extent of myocardial vs. systemic disposition of ASCs in large animal models following local delivery to the myocardium.In an initial experiment, dose-dependent effects of ASC delivery on coronary circulation in normal swine were evaluated to establish a tolerable ASC dosing range for intracoronary (IC) delivery. In a set of subsequent experiments, an anterior acute myocardial infarction (AMI) was created by balloon occlusion of the proximal left anterior descending (LAD) artery, followed by either IC or RCV infusion of 10(7) (111)Indium-labeled autologous ASCs 6 days following AMI. Indices of microcirculatory resistance (IMR) and coronary flow reserve (CFR) were measured before sacrifices to collect tissues for analysis at 1 or 24 hr after cell delivery.IC delivery of porcine ASCs to normal myocardium was well tolerated up to a cumulative dose of 14 × 10(6) cells (approximately 0.5 × 10(6) cells/kg). There was evidence suggesting microcirculatory trapping of ASC: at unit doses of 50 × 10(6) ASCs, IMR and CFR were found to be persistently altered in the target LAD distribution at 7 days following delivery, whereas at 10 × 10(6) ASCs, only CFR was altered. In the context of recent MI, a significantly higher percentage of ASCs was retained at 1 hr with IC delivery compared with RCV delivery (57.2 ± 12.7% vs. 17.9 ± 1.6%, P = 0.037) but this initial difference was not apparent at 24 hr (22.6 ± 5.5% vs. 18.7 ± 8.6%; P = 0.722). In both approaches, most ASC redistributed to the pulmonary circulation by 24 hr postdelivery. There were no significant differences in CFR or IMR following ASC delivery to infarcted tissue by either route.Selective intravascular delivery of ASC by coronary arterial and venous routes leads to similarly limited myocardial cell retention with predominant redistribution of cells to the lungs. IC arterial delivery of ASC leads to only transiently greater myocardial retention, which is accompanied by obstruction of normal regions of coronary microcirculation at higher doses. The predominant intrapulmonary localization of cells following local delivery via both methods prompts the notion that systemic delivery of ASC might provide similarly beneficial outcomes while avoiding risks of inadvertent microcirculatory compromise." @default.
- W1871625715 created "2016-06-24" @default.
- W1871625715 creator A5001575622 @default.
- W1871625715 creator A5025926408 @default.
- W1871625715 creator A5038864277 @default.
- W1871625715 creator A5067351808 @default.
- W1871625715 creator A5068359233 @default.
- W1871625715 creator A5073478428 @default.
- W1871625715 creator A5080840249 @default.
- W1871625715 creator A5081939392 @default.
- W1871625715 creator A5084502533 @default.
- W1871625715 date "2013-10-07" @default.
- W1871625715 modified "2023-10-17" @default.
- W1871625715 title "Intracoronary and retrograde coronary venous myocardial delivery of adipose‐derived stem cells in swine infarction lead to transient myocardial trapping with predominant pulmonary redistribution" @default.
- W1871625715 cites W1675723454 @default.
- W1871625715 cites W1985636817 @default.
- W1871625715 cites W1986276374 @default.
- W1871625715 cites W2021634519 @default.
- W1871625715 cites W2021916724 @default.
- W1871625715 cites W2039092880 @default.
- W1871625715 cites W2045911549 @default.
- W1871625715 cites W2047502426 @default.
- W1871625715 cites W2055901102 @default.
- W1871625715 cites W2056270039 @default.
- W1871625715 cites W2065937657 @default.
- W1871625715 cites W2071019778 @default.
- W1871625715 cites W2075222271 @default.
- W1871625715 cites W2076229475 @default.
- W1871625715 cites W2086980194 @default.
- W1871625715 cites W2087917616 @default.
- W1871625715 cites W2090180459 @default.
- W1871625715 cites W2092892225 @default.
- W1871625715 cites W2106193879 @default.
- W1871625715 cites W2106672664 @default.
- W1871625715 cites W2111486034 @default.
- W1871625715 cites W2111561563 @default.
- W1871625715 cites W2112899131 @default.
- W1871625715 cites W2124857894 @default.
- W1871625715 cites W2138811791 @default.
- W1871625715 cites W2144577699 @default.
- W1871625715 cites W2161293113 @default.
- W1871625715 cites W2167935253 @default.
- W1871625715 cites W3014622906 @default.
- W1871625715 doi "https://doi.org/10.1002/ccd.24659" @default.
- W1871625715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4181717" @default.
- W1871625715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22972685" @default.
- W1871625715 hasPublicationYear "2013" @default.
- W1871625715 type Work @default.
- W1871625715 sameAs 1871625715 @default.
- W1871625715 citedByCount "38" @default.
- W1871625715 countsByYear W18716257152014 @default.
- W1871625715 countsByYear W18716257152015 @default.
- W1871625715 countsByYear W18716257152016 @default.
- W1871625715 countsByYear W18716257152017 @default.
- W1871625715 countsByYear W18716257152018 @default.
- W1871625715 countsByYear W18716257152019 @default.
- W1871625715 countsByYear W18716257152020 @default.
- W1871625715 countsByYear W18716257152021 @default.
- W1871625715 countsByYear W18716257152022 @default.
- W1871625715 countsByYear W18716257152023 @default.
- W1871625715 crossrefType "journal-article" @default.
- W1871625715 hasAuthorship W1871625715A5001575622 @default.
- W1871625715 hasAuthorship W1871625715A5025926408 @default.
- W1871625715 hasAuthorship W1871625715A5038864277 @default.
- W1871625715 hasAuthorship W1871625715A5067351808 @default.
- W1871625715 hasAuthorship W1871625715A5068359233 @default.
- W1871625715 hasAuthorship W1871625715A5073478428 @default.
- W1871625715 hasAuthorship W1871625715A5080840249 @default.
- W1871625715 hasAuthorship W1871625715A5081939392 @default.
- W1871625715 hasAuthorship W1871625715A5084502533 @default.
- W1871625715 hasBestOaLocation W18716257152 @default.
- W1871625715 hasConcept C126322002 @default.
- W1871625715 hasConcept C158846371 @default.
- W1871625715 hasConcept C164705383 @default.
- W1871625715 hasConcept C2776157398 @default.
- W1871625715 hasConcept C28328180 @default.
- W1871625715 hasConcept C500558357 @default.
- W1871625715 hasConcept C54355233 @default.
- W1871625715 hasConcept C71924100 @default.
- W1871625715 hasConcept C86803240 @default.
- W1871625715 hasConceptScore W1871625715C126322002 @default.
- W1871625715 hasConceptScore W1871625715C158846371 @default.
- W1871625715 hasConceptScore W1871625715C164705383 @default.
- W1871625715 hasConceptScore W1871625715C2776157398 @default.
- W1871625715 hasConceptScore W1871625715C28328180 @default.
- W1871625715 hasConceptScore W1871625715C500558357 @default.
- W1871625715 hasConceptScore W1871625715C54355233 @default.
- W1871625715 hasConceptScore W1871625715C71924100 @default.
- W1871625715 hasConceptScore W1871625715C86803240 @default.
- W1871625715 hasIssue "1" @default.
- W1871625715 hasLocation W18716257151 @default.
- W1871625715 hasLocation W18716257152 @default.
- W1871625715 hasLocation W18716257153 @default.
- W1871625715 hasLocation W18716257154 @default.
- W1871625715 hasLocation W18716257155 @default.
- W1871625715 hasOpenAccess W1871625715 @default.
- W1871625715 hasPrimaryLocation W18716257151 @default.
- W1871625715 hasRelatedWork W1531601525 @default.
- W1871625715 hasRelatedWork W2032406302 @default.
- W1871625715 hasRelatedWork W2411035412 @default.