FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1871696246> ?p ?o ?g. }

• W1871696246 endingPage "277" @default.
• W1871696246 startingPage "271" @default.
• W1871696246 abstract "The lung is continuously exposed to the external environment and its mixtures of complex antigens through the air we breathe. It is estimated that the resting human adult inhales 12,000 liters of air each day, while even mild physical activity can double or triple this amount (85). In addition to anatomical barriers, such as airway angulation, mucociliary clearance, and coughing, both humoral and cellular defense mechanisms play an important role in maintaining the viability of the host. One of the first lines of defense against particulate matter is mucociliary clearance and phagocytic activity of alveolar macrophages. Antigen entering the pulmonary tract encounters antigen-presenting cells comprised of alveolar and interstitial macrophages and effector T lymphocytes (reviewed in reference 1). This encounter leads to a complex sequence of events that results in cell migration and activation at a site of inflammation, with the subsequent development of lymphocyte functional effector activity. After many years of study there is still a paucity of information on the origin, half-life, fate, and specific function of pulmonary lymphocytes in health and disease (80).Protective immunity against inhaled antigens is mediated by the lymphocytes that are localized to the surface of the respiratory tract. The compartments in the lung where lymphocytes are present are (i) the epithelium and lamina propria of the air-conducting regions, (ii) the bronchus-associated lymphoid tissue (BALT), which is found commonly in certain animals, i.e., rabbit and rats, (iii) the pulmonary interstitium and vascular beds, and (iv) the bronchoalveolar space. Lymphocytes present in the mucociliary epithelium of the trachea and bronchi are mainly CD8+ T cells. In the bronchial epithelium Fournier et al. (34) found 18 T cells per 100 epithelial cells but essentially no B cells. About 1% of these T cells express the γδ T-cell receptor (31). In contrast to the epithelium, the bronchial lamina propria contains more CD4+ than CD8+ T cells. The majority of these T cells express the memory marker of CD45RO (25). Also, this area shows more surface immunoglobulin-bearing lymphocytes (54). In the human, in contrast to rabbits and rats, BALT is present at birth but disappears in the adult lung. However, after certain stimuli such as cigarette smoking, BALT can develop in adults (90). In the whole human lung interstitium Holt et al. (51) calculated 10 × 109 lymphocytes, a number equivalent to the number of lymphocytes present in human circulating blood.Lymphocytes in the bronchoalveolar space are the most easily accessible of the lymphocytes in the human lung. It has been estimated that the total number of these lymphocytes on the air side of the epithelium is between 2 × 108 and 4 × 108 (22, 54). This number represents about 5% of the total circulating lymphocyte pool in humans or about 5% of the size of the interstitial lung pool." @default.
• W1871696246 created "2016-06-24" @default.
• W1871696246 creator A5009417693 @default.
• W1871696246 date "1998-05-01" @default.
• W1871696246 modified "2023-09-26" @default.
• W1871696246 title "Immunophenotyping of Bronchoalveolar Lavage Lymphocytes" @default.
• W1871696246 cites W1509933819 @default.
• W1871696246 cites W1842021509 @default.
• W1871696246 cites W1891751189 @default.
• W1871696246 cites W191142670 @default.
• W1871696246 cites W1937281789 @default.
• W1871696246 cites W1950788246 @default.
• W1871696246 cites W1966155498 @default.
• W1871696246 cites W1968783638 @default.
• W1871696246 cites W1970544827 @default.
• W1871696246 cites W1971084987 @default.
• W1871696246 cites W1971105581 @default.
• W1871696246 cites W1972787710 @default.
• W1871696246 cites W1972960202 @default.
• W1871696246 cites W1975155832 @default.
• W1871696246 cites W1977863322 @default.
• W1871696246 cites W1978532917 @default.
• W1871696246 cites W1979874532 @default.
• W1871696246 cites W1980667816 @default.
• W1871696246 cites W1985332372 @default.
• W1871696246 cites W1986936646 @default.
• W1871696246 cites W1989616712 @default.
• W1871696246 cites W1991208255 @default.
• W1871696246 cites W1992717447 @default.
• W1871696246 cites W1997608175 @default.
• W1871696246 cites W2002559282 @default.
• W1871696246 cites W2003415581 @default.
• W1871696246 cites W2005643806 @default.
• W1871696246 cites W2007306879 @default.
• W1871696246 cites W2007461897 @default.
• W1871696246 cites W2007493596 @default.
• W1871696246 cites W2007559141 @default.
• W1871696246 cites W2011265750 @default.
• W1871696246 cites W2015051742 @default.
• W1871696246 cites W2016422621 @default.
• W1871696246 cites W2017723311 @default.
• W1871696246 cites W2019419424 @default.
• W1871696246 cites W2020875008 @default.
• W1871696246 cites W2026107225 @default.
• W1871696246 cites W2027153847 @default.
• W1871696246 cites W2031309127 @default.
• W1871696246 cites W2034472616 @default.
• W1871696246 cites W2035512145 @default.
• W1871696246 cites W2037776391 @default.
• W1871696246 cites W2042154110 @default.
• W1871696246 cites W2042786079 @default.
• W1871696246 cites W2043270594 @default.
• W1871696246 cites W2044664790 @default.
• W1871696246 cites W2044733111 @default.
• W1871696246 cites W2047202466 @default.
• W1871696246 cites W2050807844 @default.
• W1871696246 cites W2052028769 @default.
• W1871696246 cites W2053276759 @default.
• W1871696246 cites W2053665678 @default.
• W1871696246 cites W2056086692 @default.
• W1871696246 cites W2057755740 @default.
• W1871696246 cites W2057961448 @default.
• W1871696246 cites W2058383047 @default.
• W1871696246 cites W2060132387 @default.
• W1871696246 cites W2064011660 @default.
• W1871696246 cites W2069353968 @default.
• W1871696246 cites W2071600835 @default.
• W1871696246 cites W2071905323 @default.
• W1871696246 cites W2087035746 @default.
• W1871696246 cites W2087203935 @default.
• W1871696246 cites W2089388585 @default.
• W1871696246 cites W2089634902 @default.
• W1871696246 cites W2092583286 @default.
• W1871696246 cites W2094436737 @default.
• W1871696246 cites W2098990682 @default.
• W1871696246 cites W2102930433 @default.
• W1871696246 cites W2104289731 @default.
• W1871696246 cites W2108710359 @default.
• W1871696246 cites W2109515608 @default.
• W1871696246 cites W2111539751 @default.
• W1871696246 cites W2116277047 @default.
• W1871696246 cites W2116614343 @default.
• W1871696246 cites W2128003170 @default.
• W1871696246 cites W2131539234 @default.
• W1871696246 cites W2133055753 @default.
• W1871696246 cites W2133769637 @default.
• W1871696246 cites W2138556841 @default.
• W1871696246 cites W2146474004 @default.
• W1871696246 cites W2147232365 @default.
• W1871696246 cites W2154558891 @default.
• W1871696246 cites W2156669028 @default.
• W1871696246 cites W2158806388 @default.
• W1871696246 cites W2160169764 @default.
• W1871696246 cites W2161833907 @default.
• W1871696246 cites W2162819596 @default.
• W1871696246 cites W2169497849 @default.
• W1871696246 cites W2320667912 @default.
• W1871696246 cites W2334187557 @default.

• next