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- W1871751979 endingPage "159" @default.
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- W1871751979 abstract "High-density lipoprotein (HDL) is inversely associated with cardiovascular disease. Here we first review prior knowledge of HDL, focusing on HDL-modifying genes identified from classic genetic disorders, and discuss drug discovery efforts related to these known genes. We then review large genome-wide association studies (GWAS) that identified additional novel HDL-associated genes that function in lipid metabolism, diabetes, obesity, lipid trafficking, transcription, chromatin remodeling, RNA processing, and signal transduction. Several novel genes with no apparent relationship to HDL metabolism were also found. Although several HDL-associated genes found by GWASs are linked to coronary artery disease, it is difficult to assign causality specifically to HDL due to their association with additional factors, such as obesity, diabetes, elevated triglycerides, or other traits. There is growing realization that the historic metric for quantifying HDL cholesterol may be a relatively poor indicator of HDL function. Nonetheless, the GWASs have identified a plethora of novel genes that are attractive therapeutic targets." @default.
- W1871751979 created "2016-06-24" @default.
- W1871751979 creator A5059328563 @default.
- W1871751979 creator A5068951391 @default.
- W1871751979 date "2016-01-01" @default.
- W1871751979 modified "2023-10-18" @default.
- W1871751979 title "Discovery of High-Density Lipoprotein Gene Targets from Classical Genetics to Genome-Wide Association Studies" @default.
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