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• W1871848292 startingPage "553" @default.
• W1871848292 abstract "ABSTRACT Recombination processes acting on tandem arrays are suggested here to have probable intrinsic biases, producing an expected net decrease in array size following each event, in contrast to previous models which assume no net change in array size. We examine the implications of this by modeling copy number dynamics in a tandem array under the joint interactions of sister-strand unequal crossing over (rate γ per generation per copy) and intrastrand recombination resulting in deletion (rate ∊ per generation per copy). Assuming no gene amplification or selection, the expected mean persistence time of an array starting with z excess copies (i.e., array size z + 1) is z(1 + γ/∊) recombinational events. Nontrivial equilibrium distributions of array sizes exist when gene amplification or certain forms of selection are considered. We characterize the equilibrium distribution for both a simple model of gene amplification and under the assumption that selection imposes a minimal array size, n. For the latter case, n + 1/03B1 is an upper bound for mean array size under fairly general conditions, where α(=2∊/γ) is the scaled deletion rate. Further, the distribution of excess copies over n is bounded above by a geometric distribution with parameter α/(1 + α). Tandem arrays are unlikely to be greatly expanded by unequal crossing over unless α &lt;&lt; 1, implying that other mechanisms, such as gene amplification, are likely important in the evolution of large arrays. Thus unequal crossing over, by itself, is likely insufficient to account for satellite DNA." @default.
• W1871848292 created "2016-06-24" @default.
• W1871848292 creator A5038811932 @default.
• W1871848292 date "1987-03-01" @default.
• W1871848292 modified "2023-09-30" @default.
• W1871848292 title "Persistence of Tandem Arrays: Implications for Satellite and Simple-Sequence DNAs" @default.
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• W1871848292 doi "https://doi.org/10.1093/genetics/115.3.553" @default.
• W1871848292 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1216357" @default.
• W1871848292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3569882" @default.
• W1871848292 hasPublicationYear "1987" @default.
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