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- W1871909826 abstract "The apoptotic programme is evolutionarily conserved between yeast and metazoan organisms. We have previously identified a number of mammalian cDNAs capable of suppressing the deleterious effects of Bax expression in yeast. We herein report that one such suppressor, named Tsc22((86)), represents the C-terminal 86 amino acids of the previously characterized leucine zipper (LZ) motif-containing transcriptional regulator Tsc22. Employing a genome-wide two-hybrid screen, functional genomics, and deletion mutagenesis approaches, we conclude that Tsc22((86))-mediated antiapoptosis is independent of the LZ motif and is likely independent of effects on gene transcription. Rather, a 16-residue sequence within the conserved 56-residue TSC22 domain is necessary for antiapoptosis. The presence of a similar sequence was used to predict an antiapoptotic role for two yeast proteins, Sno1p and Fyv10p. Overexpression and knock-out experiments were used to validate this prediction. These findings demonstrate the potential of studying heterologous proteins in yeast to uncover novel biological insights into the regulation of apoptosis." @default.
- W1871909826 created "2016-06-24" @default.
- W1871909826 creator A5011541246 @default.
- W1871909826 creator A5023041153 @default.
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- W1871909826 creator A5056732712 @default.
- W1871909826 creator A5079949582 @default.
- W1871909826 creator A5080713003 @default.
- W1871909826 date "2008-03-18" @default.
- W1871909826 modified "2023-10-13" @default.
- W1871909826 title "A TSC22-like motif defines a novel antiapoptotic protein family" @default.
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- W1871909826 doi "https://doi.org/10.1111/j.1567-1364.2008.00367.x" @default.
- W1871909826 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2593406" @default.
- W1871909826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18355271" @default.