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- W187193411 abstract "Leptin, a protein hormone secreted by adipose tissue, plays an important role in regulating energy metabolism and immune response. In this study we evaluated the urinary metabolomic profiles of obese leptin receptor (lepR) mutant mice. We compared mice carrying spontaneous deletion of LepR signaling pathway (db/db) to those carrying a point mutation (amino acid 1138) specifically creating dysfunction of the lepR-STAT-3 signaling pathway (s/s). Despite similar extremes of adiposity, these mouse models have robust differences in glucose homeostasis, suggesting specific effects of leptin mediated by non-STAT-3 LepR pathways. We examined the urinary metabolomic profiles of db/db and s/s mice at 12-weeks of age. Proton Nuclear magnetic Resonance spectroscopy (1HNMR) was conducted on 24 hour urine samples in Deuterium oxide (D2O) using a 500 MHz instrument at 25° C. Principle component analysis showed clear separation of urine NMR spectra between the groups (p < 0.05). The CHENOMX metabolite database identified several metabolites which were different between the two mouse models, including strong differences in metabolites associated with glycine and serine metabolism. The results suggest that the metabolomic profile of db/db and s/s mice are fundamentally different and provide interesting in vivo insight into the unique metabolic effects of leptin exerted through non-STAT3 LepR pathways." @default.
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- W187193411 date "2008-03-01" @default.
- W187193411 modified "2023-09-27" @default.
- W187193411 title "Metabolomic profiles of leptin receptor mutant mice" @default.
- W187193411 doi "https://doi.org/10.1096/fasebj.22.1_supplement.882.3" @default.
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