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• W1872022384 endingPage "5529" @default.
• W1872022384 startingPage "5522" @default.
• W1872022384 abstract "Abstract Development of T cell lineages and the role of the thymus as a source of immature T cells in parotid (PG) and submandibular salivary glands (SMG) were studied in Fischer 344 rats using the Thy-1/CD45RC/RT6 expression model. In addition, the phenotypes of salivary gland lymphocytes were compared with other conventional and extrathymic populations. PG mononuclear cells consisted of T cells (38%), B cells (29%), and NK cells (4%). SMG had 19% T cells, 7% B cells, 37% NK cells, and an unusual population of CD3−/RT6+ cells. In comparison with lymph node (LN), both PG and SMG were enriched in immature (Thy-1+) and activated (Thy-1−/CD45RC−/RT6−) T cells. Unchanged percentages of Thy-1+ T cells in PG and SMG following short-term adult thymectomy indicated that immature salivary gland T cells had an extrathymic source. In contrast, thymectomy eliminated LN recent thymic emigrants. SMG had T cells with characteristics of extrathymic populations, expressing TCRγδ+ (28%), the CD8αα homodimer (11%), and NKR-P1A (66%). Many SMG T cells expressed integrin αEβ7. PG T cells resembled those isolated from LN in respect to TCR and CD8 isoform usage, but were enriched in αEβ7+ T cells and in NKT cells. Thus, salivary gland mononuclear cells are composed of a variety of subpopulations whose distributions differ between SMG and PG and are distinct from LN. These studies provide a basis for further investigation of regionalization in the mucosal immune network and are relevant to the design of vaccine regimens and intervention during pathological immune processes." @default.
• W1872022384 created "2016-06-24" @default.
• W1872022384 creator A5014818341 @default.
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• W1872022384 date "2001-05-01" @default.
• W1872022384 modified "2023-09-25" @default.
• W1872022384 title "Lymphocyte Lineages at Mucosal Effector Sites: Rat Salivary Glands" @default.
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• W1872022384 doi "https://doi.org/10.4049/jimmunol.166.9.5522" @default.
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• W1872022384 hasPublicationYear "2001" @default.
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