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- W187222820 abstract "The Gram-negative enteropathogen Yersinia pseudotuberculosis possesses a number of regulatory systems that detect cell envelope damage caused by noxious extracytoplasmic stresses. The CpxA sensor kinase and CpxR response regulator two-component regulatory system is one such pathway. Active Cpx signalling upregulates various factors designed to repair and restore cell envelope integrity. Concomitantly, this pathway also down-regulates key determinants of virulence. In Yersinia, cpxA deletion accumulates high levels of phosphorylated CpxR (CpxR~P). Accumulated CpxR~P directly repressed rovA expression and this limited expression of virulence-associated processes. A second transcriptional regulator, RovM, also negatively regulates rovA expression in response to nutrient stress. Hence, this study aimed to determine if CpxR~P can influence rovA expression through control of RovM levels. We determined that the active CpxR~P isoform bound to the promoter of rovM and directly induced its expression, which naturally associated with a concurrent reduction in rovA expression. Site-directed mutagenesis of the CpxR~P binding sequence in the rovM promoter region desensitised rovM expression to CpxR~P. These data suggest that accumulated CpxR~P inversely manipulates the levels of two global transcriptional regulators, RovA and RovM, and this would be expected to have considerable influence on Yersinia pathophysiology and metabolism." @default.
- W187222820 created "2016-06-24" @default.
- W187222820 creator A5002721999 @default.
- W187222820 creator A5007200921 @default.
- W187222820 creator A5009964498 @default.
- W187222820 creator A5048774346 @default.
- W187222820 creator A5048854682 @default.
- W187222820 creator A5055807985 @default.
- W187222820 creator A5075644847 @default.
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- W187222820 creator A5084523333 @default.
- W187222820 creator A5089133830 @default.
- W187222820 creator A5089268675 @default.
- W187222820 date "2018-12-17" @default.
- W187222820 modified "2023-09-27" @default.
- W187222820 title "The <i>Yersinia pseudotuberculosis</i> Cpx envelope stress system contributes to transcriptional activation of <i>rovM</i>" @default.
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