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- W1872235201 endingPage "1102" @default.
- W1872235201 startingPage "1089" @default.
- W1872235201 abstract "Branched‐chain lipids are important components of the human diet and are used as drug molecules, e.g. ibuprofen. Owing to the presence of methyl groups on their carbon chains, they cannot be metabolized in mitochondria, and instead are processed and degraded in peroxisomes. Several different oxidative degradation pathways for these lipids are known, including α‐oxidation, β‐oxidation, and ω‐oxidation. Dietary branched‐chain lipids (especially phytanic acid) have attracted much attention in recent years, due to their link with prostate, breast, colon and other cancers as well as their role in neurological disease. A central role in all the metabolic pathways is played by α‐methylacyl‐CoA racemase (AMACR), which regulates metabolism of these lipids and drugs. AMACR catalyses the chiral inversion of a diverse number of 2‐methyl acids (as their CoA esters), and regulates the entry of branched‐chain lipids into the peroxisomal and mitochondrial β‐oxidation pathways. This review brings together advances in the different disciplines, and considers new research in both the metabolism of branched‐chain lipids and their role in cancer, with particular emphasis on the crucial role played by AMACR. These recent advances enable new preventative and treatment strategies for cancer." @default.
- W1872235201 created "2016-06-24" @default.
- W1872235201 creator A5016634968 @default.
- W1872235201 creator A5036024913 @default.
- W1872235201 creator A5050962954 @default.
- W1872235201 creator A5066079193 @default.
- W1872235201 date "2008-03-01" @default.
- W1872235201 modified "2023-10-18" @default.
- W1872235201 title "α-Methylacyl-CoA racemase - an ‘obscure’ metabolic enzyme takes centre stage" @default.
- W1872235201 cites W1496079625 @default.
- W1872235201 cites W1530099175 @default.
- W1872235201 cites W1586527298 @default.
- W1872235201 cites W1876657133 @default.
- W1872235201 cites W1915092483 @default.
- W1872235201 cites W1930548389 @default.
- W1872235201 cites W1934014088 @default.
- W1872235201 cites W1964319629 @default.
- W1872235201 cites W1965309337 @default.
- W1872235201 cites W1966056172 @default.
- W1872235201 cites W1969582263 @default.
- W1872235201 cites W1973940014 @default.
- W1872235201 cites W1974161676 @default.
- W1872235201 cites W1974647796 @default.
- W1872235201 cites W1976774703 @default.
- W1872235201 cites W1977723976 @default.
- W1872235201 cites W1979383399 @default.
- W1872235201 cites W1985786011 @default.
- W1872235201 cites W1987684836 @default.
- W1872235201 cites W1988669054 @default.
- W1872235201 cites W1990718526 @default.
- W1872235201 cites W1993501421 @default.
- W1872235201 cites W1995465934 @default.
- W1872235201 cites W1995620315 @default.
- W1872235201 cites W1998884175 @default.
- W1872235201 cites W2000975616 @default.
- W1872235201 cites W2001734409 @default.
- W1872235201 cites W2005767012 @default.
- W1872235201 cites W2012251449 @default.
- W1872235201 cites W2012262926 @default.
- W1872235201 cites W2015682308 @default.
- W1872235201 cites W2016433227 @default.
- W1872235201 cites W2020042552 @default.
- W1872235201 cites W2022904488 @default.
- W1872235201 cites W2027614771 @default.
- W1872235201 cites W2028778513 @default.
- W1872235201 cites W2028872385 @default.
- W1872235201 cites W2029376999 @default.
- W1872235201 cites W2031652335 @default.
- W1872235201 cites W2034343925 @default.
- W1872235201 cites W2035644151 @default.
- W1872235201 cites W2036104015 @default.
- W1872235201 cites W2038850987 @default.
- W1872235201 cites W2041167465 @default.
- W1872235201 cites W2043266398 @default.
- W1872235201 cites W2044708468 @default.
- W1872235201 cites W2046146399 @default.
- W1872235201 cites W2049230829 @default.
- W1872235201 cites W2049325706 @default.
- W1872235201 cites W2051500609 @default.
- W1872235201 cites W2053129975 @default.
- W1872235201 cites W2053773664 @default.
- W1872235201 cites W2057477742 @default.
- W1872235201 cites W2058965953 @default.
- W1872235201 cites W2060460022 @default.
- W1872235201 cites W2063023403 @default.
- W1872235201 cites W2063876600 @default.
- W1872235201 cites W2064267910 @default.
- W1872235201 cites W2065474611 @default.
- W1872235201 cites W2070168741 @default.
- W1872235201 cites W2076919214 @default.
- W1872235201 cites W2078927874 @default.
- W1872235201 cites W2079042612 @default.
- W1872235201 cites W2083319196 @default.
- W1872235201 cites W2083664020 @default.
- W1872235201 cites W2084893672 @default.
- W1872235201 cites W2099356672 @default.
- W1872235201 cites W2102453168 @default.
- W1872235201 cites W2102979212 @default.
- W1872235201 cites W2104241972 @default.
- W1872235201 cites W2107633399 @default.
- W1872235201 cites W2110188341 @default.
- W1872235201 cites W2111315915 @default.
- W1872235201 cites W2115034412 @default.
- W1872235201 cites W2115449551 @default.
- W1872235201 cites W2116575688 @default.
- W1872235201 cites W2117270297 @default.
- W1872235201 cites W2123603132 @default.
- W1872235201 cites W2124768387 @default.
- W1872235201 cites W2126108038 @default.
- W1872235201 cites W2134397116 @default.
- W1872235201 cites W2135997554 @default.
- W1872235201 cites W2138889171 @default.
- W1872235201 cites W2139154860 @default.
- W1872235201 cites W2141371533 @default.
- W1872235201 cites W2141615785 @default.
- W1872235201 cites W2142048338 @default.
- W1872235201 cites W2142572833 @default.
- W1872235201 cites W2142963329 @default.