Matches in SemOpenAlex for { <https://semopenalex.org/work/W1872421022> ?p ?o ?g. }
- W1872421022 endingPage "8" @default.
- W1872421022 startingPage "1" @default.
- W1872421022 abstract "Alzheimer’s disease (AD) is a multifactorial metabolic brain disorder characterized by protein aggregates, synaptic failure, and cognitive impairment. In the AD brain is common to observe the accumulation of senile plaques formed by amyloid-beta (A β ) peptide and the neurofibrillary tangles composed of modified tau protein, which both lead to cellular damage and progressive neurodegeneration. Currently, there is no effective therapy for AD; however several studies have shown that the treatments with the peroxisome proliferators activated receptor-gamma (PPAR γ ) agonists known as thiazolidinedione drugs (TZDs), like rosiglitazone and pioglitazone, attenuate neurodegeneration and improve cognition in mouse models and patients with mild-to-moderate AD. Furthermore, studies on animal models have shown that TZDs inhibit neuroinflammation, facilitate amyloid- β plaque clearance, enhance mitochondrial function, improve synaptic plasticity, and, more recently, attenuate tau hyperphosphorylation. How TZDs may improve or reduce these pathologic signs of AD and what the mechanisms and the implicated pathways in which these drugs work are are questions that remain to be answered. However, in this review, we will discuss several cellular targets, in which TZDs can be acting against the neurodegeneration." @default.
- W1872421022 created "2016-06-24" @default.
- W1872421022 creator A5007582714 @default.
- W1872421022 creator A5050126878 @default.
- W1872421022 date "2015-01-01" @default.
- W1872421022 modified "2023-10-18" @default.
- W1872421022 title "Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease" @default.
- W1872421022 cites W1507728730 @default.
- W1872421022 cites W1526704928 @default.
- W1872421022 cites W1554596985 @default.
- W1872421022 cites W1616122655 @default.
- W1872421022 cites W1650328097 @default.
- W1872421022 cites W1953508171 @default.
- W1872421022 cites W1963635405 @default.
- W1872421022 cites W1966730902 @default.
- W1872421022 cites W1968659767 @default.
- W1872421022 cites W1970613754 @default.
- W1872421022 cites W1972816297 @default.
- W1872421022 cites W1973756832 @default.
- W1872421022 cites W1983271977 @default.
- W1872421022 cites W1986309965 @default.
- W1872421022 cites W1995735916 @default.
- W1872421022 cites W1999546189 @default.
- W1872421022 cites W2001330707 @default.
- W1872421022 cites W2002181764 @default.
- W1872421022 cites W2002937059 @default.
- W1872421022 cites W2004205778 @default.
- W1872421022 cites W2006505402 @default.
- W1872421022 cites W2009733869 @default.
- W1872421022 cites W2010156024 @default.
- W1872421022 cites W2012525940 @default.
- W1872421022 cites W2017422058 @default.
- W1872421022 cites W2028457208 @default.
- W1872421022 cites W2033726284 @default.
- W1872421022 cites W2042200036 @default.
- W1872421022 cites W2045176723 @default.
- W1872421022 cites W2048224964 @default.
- W1872421022 cites W2049230496 @default.
- W1872421022 cites W2057850192 @default.
- W1872421022 cites W2065336907 @default.
- W1872421022 cites W2073113116 @default.
- W1872421022 cites W2079938040 @default.
- W1872421022 cites W2083579642 @default.
- W1872421022 cites W2083909860 @default.
- W1872421022 cites W2085035881 @default.
- W1872421022 cites W2085667648 @default.
- W1872421022 cites W2086679674 @default.
- W1872421022 cites W2088436356 @default.
- W1872421022 cites W2094530411 @default.
- W1872421022 cites W2097478521 @default.
- W1872421022 cites W2099271519 @default.
- W1872421022 cites W2099751992 @default.
- W1872421022 cites W2104329044 @default.
- W1872421022 cites W2112499304 @default.
- W1872421022 cites W2115116381 @default.
- W1872421022 cites W2122000781 @default.
- W1872421022 cites W2123281082 @default.
- W1872421022 cites W2129146864 @default.
- W1872421022 cites W2129164045 @default.
- W1872421022 cites W2131047041 @default.
- W1872421022 cites W2131705782 @default.
- W1872421022 cites W2136936410 @default.
- W1872421022 cites W2272730512 @default.
- W1872421022 cites W4241136696 @default.
- W1872421022 cites W4247759744 @default.
- W1872421022 cites W5241709 @default.
- W1872421022 doi "https://doi.org/10.1155/2015/957248" @default.
- W1872421022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4637502" @default.
- W1872421022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26587016" @default.
- W1872421022 hasPublicationYear "2015" @default.
- W1872421022 type Work @default.
- W1872421022 sameAs 1872421022 @default.
- W1872421022 citedByCount "47" @default.
- W1872421022 countsByYear W18724210222016 @default.
- W1872421022 countsByYear W18724210222017 @default.
- W1872421022 countsByYear W18724210222018 @default.
- W1872421022 countsByYear W18724210222019 @default.
- W1872421022 countsByYear W18724210222020 @default.
- W1872421022 countsByYear W18724210222021 @default.
- W1872421022 countsByYear W18724210222022 @default.
- W1872421022 countsByYear W18724210222023 @default.
- W1872421022 crossrefType "journal-article" @default.
- W1872421022 hasAuthorship W1872421022A5007582714 @default.
- W1872421022 hasAuthorship W1872421022A5050126878 @default.
- W1872421022 hasBestOaLocation W18724210221 @default.
- W1872421022 hasConcept C126322002 @default.
- W1872421022 hasConcept C134018914 @default.
- W1872421022 hasConcept C142724271 @default.
- W1872421022 hasConcept C169760540 @default.
- W1872421022 hasConcept C170493617 @default.
- W1872421022 hasConcept C2776156579 @default.
- W1872421022 hasConcept C2776923340 @default.
- W1872421022 hasConcept C2776925932 @default.
- W1872421022 hasConcept C2777180221 @default.
- W1872421022 hasConcept C2777633098 @default.
- W1872421022 hasConcept C2778384471 @default.
- W1872421022 hasConcept C2779134260 @default.
- W1872421022 hasConcept C2780152017 @default.