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• W1872551835 abstract "The aim of this study was to develop a measurement protocol for noninvasive simultaneous perfusion quantification and T2 *-weighted MRI acquisition in the exercising calf muscle at 7 Tesla.Using a nonmagnetic ergometer and a dedicated in-house built calf coil array, dynamic pulsed arterial spin labeling (PASL) measurements with a temporal resolution of 12 s were performed before, during, and after plantar flexion exercise in 16 healthy volunteers.Postexercise peak perfusion in gastrocnemius muscle (GAS) was 27 ± 16 ml/100g/min, whereas in soleus (SOL) and tibialis anterior (TA) muscles it remained at baseline levels. T2 *-weighted and ASL time courses in GAS showed comparable times to peak of 161 ± 72 s and 167 ± 115 s, respectively. The T2 *-weighted signal in the GAS showed a minimum during exercise (88 ± 6 % of the baseline signal) and a peak during the recovery (122 ± 9%), whereas in all other muscles only a signal decrease was observed (minimum 91 ± 6% in SOL; 87 ± 8% in TA).We demonstrate the feasibility of dynamic perfusion quantification in skeletal muscle at 7 Tesla using PASL. This may help to better investigate the physiological processes in the skeletal muscle and also in diseases such as diabetes mellitus and peripheral arterial disease." @default.
• W1872551835 created "2016-06-24" @default.
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• W1872551835 date "2014-04-17" @default.
• W1872551835 modified "2023-10-15" @default.
• W1872551835 title "Dynamic ASL and <i>T2*</i> -weighted MRI in exercising calf muscle at 7 T: A feasibility study" @default.
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• W1872551835 doi "https://doi.org/10.1002/mrm.25242" @default.
• W1872551835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24752959" @default.
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