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- W1872836123 abstract "Adrenomedullin is a vasodilatatory peptide, important during the inflammation process and also able to regulate blood-brain barrier function. Adrenomedullin and its receptors have been shown to be glucocorticoid-dependent in many cell types, including primary T cells and the major cellular components of the blood-brain barrier. Considering that the immunosuppressant, glucocorticoids are also well-known to regulate inflammation and blood-brain barrier properties, in this research highlight we review the evidence for glucocorticoid modulation of adrenomedullin secretion and adrenomedullin receptor expression at the glial/endothelial interface during physiological and inflammatory conditions. This view would offer a platform for consideration of new therapeutic options aiming to restore or maintain the blood brain barrier." @default.
- W1872836123 created "2016-06-24" @default.
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- W1872836123 date "2014-01-15" @default.
- W1872836123 modified "2023-10-12" @default.
- W1872836123 title "Adrenomedullin and Glucocorticoids interaction at the glial/endothelial interface: two sides of the same regulatory coin?" @default.
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- W1872836123 doi "https://doi.org/10.14800/rci.25" @default.
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