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• W1873073663 abstract "<h3>Objective:</h3> To determine whether the 2D:4D ratio (ratio of the second and fourth digit lengths), a proxy for lower prenatal androgen to estrogen ratio, differs in men with and without multiple sclerosis (MS) using a case-control study design. <h3>Methods:</h3> We obtained 2 digital scans of the right hand for men with MS presenting to a scheduled clinic visit at a large MS referral center, and for men without autoimmune or endocrine diseases. All individuals were aged 18 to 65 years, right-handed, and reported no prior digit trauma. We calculated a mean 2D:4D ratio using digital calipers. In participants with MS, we assessed age at first MS symptoms, MS type, and the MS Severity Score; 51 had provided a testosterone level within 10 years of symptom onset. Our primary analysis was a cross-sectional comparison of the 2D:4D ratio between men with and without MS, using a 2-sample <i>t</i> test for independent samples assuming unequal variance. <h3>Results:</h3> In total, we scanned 137 men with MS and 145 men without MS. A statistically significant association between 2D:4D ratio and MS status was observed in the univariate logistic regression model (<i>p</i> < 0.05). These differences were not associated with age or race, which differed between the 2 groups. In participants with MS, the 2D:4D ratio was not correlated with MS type, age at first symptoms, or MS Severity Score (<i>p</i> > 0.15 for each), and it was not correlated with adult testosterone levels (<i>r</i> = 0.06, <i>p</i> = 0.68, n = 51). <h3>Conclusions:</h3> During the prenatal period, low androgens could represent a risk factor for MS." @default.
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• W1873073663 date "2015-09-04" @default.
• W1873073663 modified "2023-10-17" @default.
• W1873073663 title "The 2D:4D ratio, a proxy for prenatal androgen levels, differs in men with and without MS" @default.
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• W1873073663 doi "https://doi.org/10.1212/wnl.0000000000001990" @default.
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