Matches in SemOpenAlex for { <https://semopenalex.org/work/W1873207987> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1873207987 endingPage "5208" @default.
- W1873207987 startingPage "5202" @default.
- W1873207987 abstract "Abstract T cell activation plays a major role in the ability of the HIV to remain latent or establish a productive infection. The alpha-chain of the IL-2R (CD25, Tac, p55) is expressed on activated but not resting T cells and therefore represents an ideal marker to distinguish activated from resting T cells. The present studies were designed to define the role of CD25+ (activated) and CD25- (resting) T cells in an acute HIV infection in vitro. This objective was accomplished by selectively killing CD25+ cells with an anti-CD25-ricin A chain immunotoxin (RFT5-deglycosylated ricin A (dgA)) either before or after HIV infection, and then determining the effect of eliminating these cells on the secretion of viral p24 Ag. Three major findings have emerged from this study: 1) Elimination of the small population (3 to 5%) of activated, CD25+ cells present in normal PBMC before HIV infection results in a 99% reduction in p24 secretion. 2) RFT5-dgA, an immunotoxin directed against CD25, kills HIV-infected CD25+ cells. Elimination of the CD25+ cells after infection with HIV virtually stops viral production and the spread of the infection in these cultures. This was confirmed by coculturing RFT5-dgA-treated PBMC with H9 cells. 3) When RFT5-dgA-treated PBMC (CD25-cells) were infected with HIV and then activated with a solid phase anti-CD3 mAb, the levels of p24 produced were comparable with those of PBMC from which the CD25+ cells had not been eliminated. Taken together these findings suggest that both activated (CD25+) and resting/quiescent (CD25-) cells can be infected with HIV but that only the CD25+ cells produce viral proteins in the absence of additional activation." @default.
- W1873207987 created "2016-06-24" @default.
- W1873207987 creator A5022779495 @default.
- W1873207987 creator A5049592946 @default.
- W1873207987 creator A5074383215 @default.
- W1873207987 creator A5084475433 @default.
- W1873207987 date "1993-06-01" @default.
- W1873207987 modified "2023-10-10" @default.
- W1873207987 title "Role of CD25+ and CD25-T cells in acute HIV infection in vitro." @default.
- W1873207987 cites W1521074246 @default.
- W1873207987 cites W1528522073 @default.
- W1873207987 cites W1788854698 @default.
- W1873207987 cites W1962214045 @default.
- W1873207987 cites W1992001022 @default.
- W1873207987 cites W1992870543 @default.
- W1873207987 cites W2019508559 @default.
- W1873207987 cites W2024395223 @default.
- W1873207987 cites W2028519228 @default.
- W1873207987 cites W2055456747 @default.
- W1873207987 cites W2058598541 @default.
- W1873207987 cites W2064993900 @default.
- W1873207987 cites W2076979493 @default.
- W1873207987 cites W2090089773 @default.
- W1873207987 cites W2090218957 @default.
- W1873207987 cites W2091187418 @default.
- W1873207987 cites W2091565871 @default.
- W1873207987 cites W2338469672 @default.
- W1873207987 cites W2398282778 @default.
- W1873207987 cites W2411741276 @default.
- W1873207987 cites W49920453 @default.
- W1873207987 doi "https://doi.org/10.4049/jimmunol.150.11.5202" @default.
- W1873207987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8496611" @default.
- W1873207987 hasPublicationYear "1993" @default.
- W1873207987 type Work @default.
- W1873207987 sameAs 1873207987 @default.
- W1873207987 citedByCount "46" @default.
- W1873207987 countsByYear W18732079872012 @default.
- W1873207987 countsByYear W18732079872013 @default.
- W1873207987 countsByYear W18732079872015 @default.
- W1873207987 countsByYear W18732079872016 @default.
- W1873207987 countsByYear W18732079872019 @default.
- W1873207987 countsByYear W18732079872023 @default.
- W1873207987 crossrefType "journal-article" @default.
- W1873207987 hasAuthorship W1873207987A5022779495 @default.
- W1873207987 hasAuthorship W1873207987A5049592946 @default.
- W1873207987 hasAuthorship W1873207987A5074383215 @default.
- W1873207987 hasAuthorship W1873207987A5084475433 @default.
- W1873207987 hasBestOaLocation W18732079871 @default.
- W1873207987 hasConcept C115085202 @default.
- W1873207987 hasConcept C137061746 @default.
- W1873207987 hasConcept C159047783 @default.
- W1873207987 hasConcept C159654299 @default.
- W1873207987 hasConcept C202751555 @default.
- W1873207987 hasConcept C203014093 @default.
- W1873207987 hasConcept C2776090121 @default.
- W1873207987 hasConcept C2777371288 @default.
- W1873207987 hasConcept C542903549 @default.
- W1873207987 hasConcept C55493867 @default.
- W1873207987 hasConcept C79484868 @default.
- W1873207987 hasConcept C86803240 @default.
- W1873207987 hasConcept C8891405 @default.
- W1873207987 hasConceptScore W1873207987C115085202 @default.
- W1873207987 hasConceptScore W1873207987C137061746 @default.
- W1873207987 hasConceptScore W1873207987C159047783 @default.
- W1873207987 hasConceptScore W1873207987C159654299 @default.
- W1873207987 hasConceptScore W1873207987C202751555 @default.
- W1873207987 hasConceptScore W1873207987C203014093 @default.
- W1873207987 hasConceptScore W1873207987C2776090121 @default.
- W1873207987 hasConceptScore W1873207987C2777371288 @default.
- W1873207987 hasConceptScore W1873207987C542903549 @default.
- W1873207987 hasConceptScore W1873207987C55493867 @default.
- W1873207987 hasConceptScore W1873207987C79484868 @default.
- W1873207987 hasConceptScore W1873207987C86803240 @default.
- W1873207987 hasConceptScore W1873207987C8891405 @default.
- W1873207987 hasIssue "11" @default.
- W1873207987 hasLocation W18732079871 @default.
- W1873207987 hasLocation W18732079872 @default.
- W1873207987 hasOpenAccess W1873207987 @default.
- W1873207987 hasPrimaryLocation W18732079871 @default.
- W1873207987 hasRelatedWork W1873207987 @default.
- W1873207987 hasRelatedWork W2059918623 @default.
- W1873207987 hasRelatedWork W2084103937 @default.
- W1873207987 hasRelatedWork W2084117712 @default.
- W1873207987 hasRelatedWork W2136894448 @default.
- W1873207987 hasRelatedWork W2152764589 @default.
- W1873207987 hasRelatedWork W2326414761 @default.
- W1873207987 hasRelatedWork W2398295736 @default.
- W1873207987 hasRelatedWork W2972012778 @default.
- W1873207987 hasRelatedWork W18987839 @default.
- W1873207987 hasVolume "150" @default.
- W1873207987 isParatext "false" @default.
- W1873207987 isRetracted "false" @default.
- W1873207987 magId "1873207987" @default.
- W1873207987 workType "article" @default.