FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1873643042> ?p ?o ?g. }

• W1873643042 abstract "Prefrontal layer 6 (L6) pyramidal neurons play an important role in the adult control of attention, facilitated by their strong activation by nicotinic acetylcholine receptors. These neurons in mouse association cortex are distinctive morphologically when compared to L6 neurons in primary cortical regions. Roughly equal proportions of the prefrontal L6 neurons have apical dendrites that are long (reaching to the pial surface) vs. short (terminating in the deep layers, as in primary cortical regions). This distinct prefrontal morphological pattern is established in the post-juvenile period and appears dependent on nicotinic receptors. Here, we examine dendritic spine densities in these two subgroups of prefrontal L6 pyramidal neurons under control conditions as well as after perturbation of nicotinic acetylcholine receptors. In control mice, the long neurons have significantly greater apical and basal dendritic spine density compared to the short neurons. Furthermore, manipulations of nicotinic receptors (chrna5 deletion or chronic developmental nicotine exposure) have distinct effects on these two subgroups of L6 neurons: apical spine density is significantly reduced in long neurons, and basal spine density is significantly increased in short neurons. These changes appear dependent on the α5 nicotinic subunit encoded by chrna5. Overall, the two subgroups of prefrontal L6 neurons appear positioned to integrate information either across cortex (long neurons) or within the deep layers (short neurons), and nicotinic perturbations differently alter spine density within each subgroup." @default.
• W1873643042 created "2016-06-24" @default.
• W1873643042 creator A5000299323 @default.
• W1873643042 creator A5011612065 @default.
• W1873643042 creator A5019429958 @default.
• W1873643042 creator A5047531759 @default.
• W1873643042 date "2015-10-08" @default.
• W1873643042 modified "2023-10-18" @default.
• W1873643042 title "Dendritic spine density of prefrontal layer 6 pyramidal neurons in relation to apical dendrite sculpting by nicotinic acetylcholine receptors" @default.
• W1873643042 cites W1587505135 @default.
• W1873643042 cites W1645542202 @default.
• W1873643042 cites W1816663997 @default.
• W1873643042 cites W1963750875 @default.
• W1873643042 cites W1971335223 @default.
• W1873643042 cites W1972316696 @default.
• W1873643042 cites W1973427834 @default.
• W1873643042 cites W1974385176 @default.
• W1873643042 cites W1974622727 @default.
• W1873643042 cites W1974719053 @default.
• W1873643042 cites W1974971758 @default.
• W1873643042 cites W1980643144 @default.
• W1873643042 cites W1988797981 @default.
• W1873643042 cites W1994849536 @default.
• W1873643042 cites W1994912021 @default.
• W1873643042 cites W1997524269 @default.
• W1873643042 cites W2004425853 @default.
• W1873643042 cites W2016159363 @default.
• W1873643042 cites W2017182954 @default.
• W1873643042 cites W2020862885 @default.
• W1873643042 cites W2021613777 @default.
• W1873643042 cites W2021755555 @default.
• W1873643042 cites W2022503151 @default.
• W1873643042 cites W2023794288 @default.
• W1873643042 cites W2026108792 @default.
• W1873643042 cites W2027749726 @default.
• W1873643042 cites W2032044543 @default.
• W1873643042 cites W2036161685 @default.
• W1873643042 cites W2038124070 @default.
• W1873643042 cites W2041086280 @default.
• W1873643042 cites W2041261566 @default.
• W1873643042 cites W2041556105 @default.
• W1873643042 cites W2045621697 @default.
• W1873643042 cites W2045933100 @default.
• W1873643042 cites W2049717607 @default.
• W1873643042 cites W2058642681 @default.
• W1873643042 cites W2065469428 @default.
• W1873643042 cites W2070469268 @default.
• W1873643042 cites W2072060777 @default.
• W1873643042 cites W2075847995 @default.
• W1873643042 cites W2078096392 @default.
• W1873643042 cites W2078626262 @default.
• W1873643042 cites W2082628782 @default.
• W1873643042 cites W2087129491 @default.
• W1873643042 cites W2088228824 @default.
• W1873643042 cites W2089161864 @default.
• W1873643042 cites W2091111430 @default.
• W1873643042 cites W2093843951 @default.
• W1873643042 cites W2097327422 @default.
• W1873643042 cites W2101491694 @default.
• W1873643042 cites W2109801685 @default.
• W1873643042 cites W2110970377 @default.
• W1873643042 cites W2120716199 @default.
• W1873643042 cites W2126834955 @default.
• W1873643042 cites W2132605695 @default.
• W1873643042 cites W2136715772 @default.
• W1873643042 cites W2137700545 @default.
• W1873643042 cites W2139856187 @default.
• W1873643042 cites W2140549509 @default.
• W1873643042 cites W2143485697 @default.
• W1873643042 cites W2145935269 @default.
• W1873643042 cites W2146936296 @default.
• W1873643042 cites W2149171047 @default.
• W1873643042 cites W2152072693 @default.
• W1873643042 cites W2152781875 @default.
• W1873643042 cites W2160369817 @default.
• W1873643042 cites W2160714071 @default.
• W1873643042 cites W2161064560 @default.
• W1873643042 cites W2166370054 @default.
• W1873643042 cites W2171614525 @default.
• W1873643042 cites W2226770547 @default.
• W1873643042 cites W2279313673 @default.
• W1873643042 cites W2321771839 @default.
• W1873643042 cites W4233569726 @default.
• W1873643042 doi "https://doi.org/10.3389/fncel.2015.00398" @default.
• W1873643042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4597126" @default.
• W1873643042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26500498" @default.
• W1873643042 hasPublicationYear "2015" @default.
• W1873643042 type Work @default.
• W1873643042 sameAs 1873643042 @default.
• W1873643042 citedByCount "10" @default.
• W1873643042 countsByYear W18736430422018 @default.
• W1873643042 countsByYear W18736430422019 @default.
• W1873643042 countsByYear W18736430422020 @default.
• W1873643042 countsByYear W18736430422021 @default.
• W1873643042 countsByYear W18736430422022 @default.
• W1873643042 crossrefType "journal-article" @default.
• W1873643042 hasAuthorship W1873643042A5000299323 @default.
• W1873643042 hasAuthorship W1873643042A5011612065 @default.
• W1873643042 hasAuthorship W1873643042A5019429958 @default.
• W1873643042 hasAuthorship W1873643042A5047531759 @default.

• next