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• W1873668587 abstract "Background: TRALI is a life-threatening complication of blood transfusion. Antibodies against human leukocyte antigens in donors9 serum are major causes of TRALI. Several animal models of TRALI have been developed, and the mechanism underlying TRALI development has been extensively investigated using rodent models. Although sheep models of nonimmune TRALI have been developed, large-animal models of immune TRALI have not yet been developed. Because the incidence of TRALI is low and prospective human studies are difficult to conduct, large-animal models mimicking TRALI might be useful for developing treatment options. Aim: To determine whether a swine model of TRALI can be developed using a monoclonal antibody (mAb) to swine leukocyte antigens (SLAs). Materials and methods: Male Clawn strain miniature pigs (9-10 months) were used. A mAb against SLA class I (4G8: 0.3 or 1.0 mg/kg body weight (BW)) and a control antibody (1.0 mg/kg BW) were prepared and injected into the peripheral vein after priming with or without 1 μg/kg BW of lipopolysaccharide (LPS) (n=3; each arm). Lung injury was assessed using the PaO 2 /FiO 2 (P/F) ratio and by chest X-ray monitoring. Histopathological analysis was also performed. Results: Lung injury was induced only when the 4G8 mAb with a concentration of 1.0 mg/kg BW was injected after LPS priming. The P/F ratio 90 min after the administration of the antibody had significantly decreased (p" @default.
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• W1873668587 date "2012-09-01" @default.
• W1873668587 modified "2023-10-07" @default.
• W1873668587 title "Novel swine model of transfusion-related acute lung injury (TRALI)" @default.
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