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• W1874005520 abstract "Protein interactions are essential in all biological processes. The changes brought about in the structure when a free component forms a complex with another molecule need to be characterized for a proper understanding of molecular recognition as well as for the successful implementation of docking algorithms. Here, unbound (U) and bound (B) forms of protein structures from the Protein–Protein Interaction Affinity Database are compared in order to enumerate the changes that occur at the interface atoms/residues in terms of the solvent-accessible surface area (ASA), secondary structure, temperature factors ( B factors) and disorder-to-order transitions. It is found that the interface atoms optimize contacts with the atoms in the partner protein, which leads to an increase in their ASA in the bound interface in the majority (69%) of the proteins when compared with the unbound interface, and this is independent of the root-mean-square deviation between the U and B forms. Changes in secondary structure during the transition indicate a likely extension of helices and strands at the expense of turns and coils. A reduction in flexibility during complex formation is reflected in the decrease in B factors of the interface residues on going from the U form to the B form. There is, however, no distinction in flexibility between the interface and the surface in the monomeric structure, thereby highlighting the potential problem of using B factors for the prediction of binding sites in the unbound form for docking another protein. 16% of the proteins have missing (disordered) residues in the U form which are observed (ordered) in the B form, mostly with an irregular conformation; the data set also shows differences in the composition of interface and non-interface residues in the disordered polypeptide segments as well as differences in their surface burial." @default.
• W1874005520 created "2016-06-24" @default.
• W1874005520 creator A5000031273 @default.
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• W1874005520 creator A5066935502 @default.
• W1874005520 creator A5082455222 @default.
• W1874005520 date "2015-10-16" @default.
• W1874005520 modified "2023-10-14" @default.
• W1874005520 title "Changes in protein structure at the interface accompanying complex formation" @default.
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• W1874005520 doi "https://doi.org/10.1107/s2052252515015250" @default.
• W1874005520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4645109" @default.
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