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- W1874007049 abstract "Research Article1 May 1988free access A direct link between core histone acetylation and transcriptionally active chromatin. T. R. Hebbes T. R. Hebbes Biophysics Laboratories, Portsmouth Polytechnic, UK. Search for more papers by this author A. W. Thorne A. W. Thorne Biophysics Laboratories, Portsmouth Polytechnic, UK. Search for more papers by this author C. Crane-Robinson C. Crane-Robinson Biophysics Laboratories, Portsmouth Polytechnic, UK. Search for more papers by this author T. R. Hebbes T. R. Hebbes Biophysics Laboratories, Portsmouth Polytechnic, UK. Search for more papers by this author A. W. Thorne A. W. Thorne Biophysics Laboratories, Portsmouth Polytechnic, UK. Search for more papers by this author C. Crane-Robinson C. Crane-Robinson Biophysics Laboratories, Portsmouth Polytechnic, UK. Search for more papers by this author Author Information T. R. Hebbes1, A. W. Thorne1 and C. Crane-Robinson1 1Biophysics Laboratories, Portsmouth Polytechnic, UK. The EMBO Journal (1988)7:1395-1402https://doi.org/10.1002/j.1460-2075.1988.tb02956.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info An antiserum raised against chemically acetylated histone H4 was found to recognize the epitope epsilon-N-acetyl lysine. Affinity-purified antibodies were used to fractionate oligo- and mononucleosomal chromatin fragments from the nuclei of 15-day chicken embryo erythrocytes. Antibody-bound chromatin was found to contain elevated levels of acetylated core histones. On probing with sequences of alpha D globin, an actively transcribed gene, the antibody-bound chromatin was 15- to 30-fold enriched relative to the input chromatin. Using ovalbumin sequences as a probe, no enrichment was observed. The results demonstrate directly that transcriptionally active genes carry acetylated core histones. Previous ArticleNext Article Volume 7Issue 51 May 1988In this issue RelatedDetailsLoading ..." @default.
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- W1874007049 title "A direct link between core histone acetylation and transcriptionally active chromatin." @default.
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- W1874007049 doi "https://doi.org/10.1002/j.1460-2075.1988.tb02956.x" @default.
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