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- W1874408158 abstract "Adipogenesis is tightly controlled by a complex network of transcription factors acting at different stages of differentiation. Peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein (C/EBP) family members are key regulators of this process. We have employed DNase I hypersensitive site analysis to investigate the genome-wide changes in chromatin structure that accompany the binding of adipogenic transcription factors. These analyses revealed a dramatic and dynamic modulation of the chromatin landscape during the first hours of adipocyte differentiation that coincides with cooperative binding of multiple early transcription factors (including glucocorticoid receptor, retinoid X receptor, Stat5a, C/EBPβ and -δ) to transcription factor 'hotspots'. Our results demonstrate that C/EBPβ marks a large number of these transcription factor 'hotspots' before induction of differentiation and chromatin remodelling and is required for their establishment. Furthermore, a subset of early remodelled C/EBP-binding sites persists throughout differentiation and is later occupied by PPARγ, indicating that early C/EBP family members, in addition to their well-established role in activation of PPARγ transcription, may act as pioneering factors for PPARγ binding." @default.
- W1874408158 created "2016-06-24" @default.
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- W1874408158 date "2011-03-22" @default.
- W1874408158 modified "2023-10-17" @default.
- W1874408158 title "Extensive chromatin remodelling and establishment of transcription factor ‘hotspots’ during early adipogenesis" @default.
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- W1874408158 doi "https://doi.org/10.1038/emboj.2011.65" @default.
- W1874408158 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3102274" @default.
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