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- W187444671 abstract "Nine rad (for abnormal radiation sensitivity) mutants hypersensitive to ultraviolet light were isolated in the small nematode Caenorhabditis elegans. The mutations are recessive to their wild-type alleles, map to four of the six linkage groups in C. elegans and define nine new games named rad-1 through rad-9. Two of the mutants-rad-1 and rad-2-are very hypersensitive to X rays, and three-rad-2, rad-3 and rad-4-are hypersensitive to methyl methanesulfonate under particular conditions of exposure. The hypersensitivity of these mutants to more than one DNA-damaging agent suggests that they may be abnormal in DNA repair. One mutant-rad-5, a temperature-sensitive sterile mutant-shows an elevated frequency of spontaneous mutation at more than one locus; rad-$, which shows a cold-sensitive embryogenesis, reduces meiotic X-chromosome nondisjunction tenfold and partially suppresses some but not all mutations that increase meiotic X-chromosome nondisjunction; the viability of rad-6 hermaphrodites is half that of rad-6 males at 25'; and newly mature (but not older) rad-8 hermaphrodites produce many inviable embryo progeny. Meiotic recombination frequencies were measured for seven rad mutants and found to be close to normal. ADIATION-sensitive mutants have played an important role in the develR opment of current models of DNA repair, recombination and mutation in bacteria, including the view that these processes are interrelated (for reviews, see HANAWALT et al. 1979; HANAWALT, FRIEDBERG and Fox 1978). The general approach of identifying and characterizing radiation-sensitive mutants-as well as mutants hypersensitive to chemical mutagens, an overlapping class-has" @default.
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- W187444671 date "1982-01-01" @default.
- W187444671 modified "2023-09-27" @default.
- W187444671 title "RADIATION-SENSITIVE MUTANTS OF CAENORHABDITIS" @default.
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