FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1874759552> ?p ?o ?g. }

• W1874759552 endingPage "3935" @default.
• W1874759552 startingPage "3935" @default.
• W1874759552 abstract "Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of advanced atherosclerosis Philipp Sievers,1 Lorenz Uhlmann,2 Sevil Korkmaz-Icöz,3 Christian Fastner,1 Florian Bea,1 Erwin Blessing,1 Hugo A Katus,1 Michael R Preusch11Department of Internal Medicine III, 2Institute of Medical Biometry and Informatics, 3Department of Cardiac Surgery, University of Heidelberg, Heidelberg, GermanyIntroduction: Besides their blood pressure-lowering effects, olmesartan medoxomil and amlodipine besylate exhibit additional anti-inflammatory mechanisms in atherosclerosic disease. Most of the studies investigating the effects of atherosclerosis focused on early atherosclerotic lesions, whereas lesions in human disease, at the time when medical treatment is started, are already well established. Therefore, we set up a model of advanced atherosclerosis and investigated the effects of olmesartan medoxomil, amlodipine besylate, and the combination of both on atherosclerotic lesion size and lesion composition.Materials and methods: Olmesartan medoxomil (1 mg/kg/day), amlodipine besylate (1.5 mg/kg/day), and the combination of both was added to chow and was fed to apolipoprotein E-deficient (ApoE-/-) mice at 25 weeks of age. Mice were sacrificed after 25 weeks of drug administration and perfused with formalin. Innominate arteries were dissected out and paraffin embedded. Serial sections were generated, and lesion sizes and their composition – such as minimal thickness of the fibrous cap, size of the necrotic core, and presence of calcification – were analyzed. Electrophoretic mobility shift assays were used to detect DNA-binding activity of the transcription factor nuclear factor-kappa B (NF-κB) in aortic tissue.Results: Treatment with the combination of olmesartan medoxomil and amlodipine besylate led to a significant reduction in atherosclerotic lesion size in ApoE-/- mice (olmesartan medoxomil/amlodipine besylate: 122,277±6,795 µm2, number [n]=14; versus control: 177,502±10,814 µm2, n=9; P" @default.
• W1874759552 created "2016-06-24" @default.
• W1874759552 creator A5002494168 @default.
• W1874759552 creator A5004843570 @default.
• W1874759552 creator A5015137135 @default.
• W1874759552 creator A5016393405 @default.
• W1874759552 creator A5037675983 @default.
• W1874759552 creator A5042471231 @default.
• W1874759552 creator A5049262839 @default.
• W1874759552 creator A5049310769 @default.
• W1874759552 date "2015-07-01" @default.
• W1874759552 modified "2023-10-16" @default.
• W1874759552 title "Combined treatment with olmesartan medoxomil and amlodipine besylate attenuates atherosclerotic lesion progression in a model of&nbsp;advanced atherosclerosis" @default.
• W1874759552 cites W1832728002 @default.
• W1874759552 cites W1964906337 @default.
• W1874759552 cites W1966214786 @default.
• W1874759552 cites W1983968479 @default.
• W1874759552 cites W1993340561 @default.
• W1874759552 cites W2002963575 @default.
• W1874759552 cites W2003467903 @default.
• W1874759552 cites W2008960002 @default.
• W1874759552 cites W2031047943 @default.
• W1874759552 cites W2033896075 @default.
• W1874759552 cites W2043792809 @default.
• W1874759552 cites W2048225623 @default.
• W1874759552 cites W2052435494 @default.
• W1874759552 cites W2060034277 @default.
• W1874759552 cites W2060671236 @default.
• W1874759552 cites W2083200530 @default.
• W1874759552 cites W2094629035 @default.
• W1874759552 cites W2094941678 @default.
• W1874759552 cites W2119352838 @default.
• W1874759552 cites W2119702880 @default.
• W1874759552 cites W2120058838 @default.
• W1874759552 cites W2135565300 @default.
• W1874759552 cites W2146823353 @default.
• W1874759552 cites W2147181044 @default.
• W1874759552 cites W2157413981 @default.
• W1874759552 cites W2162238307 @default.
• W1874759552 cites W2163426803 @default.
• W1874759552 cites W2164237992 @default.
• W1874759552 cites W2464300077 @default.
• W1874759552 doi "https://doi.org/10.2147/dddt.s85203" @default.
• W1874759552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4524379" @default.
• W1874759552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26251572" @default.
• W1874759552 hasPublicationYear "2015" @default.
• W1874759552 type Work @default.
• W1874759552 sameAs 1874759552 @default.
• W1874759552 citedByCount "3" @default.
• W1874759552 countsByYear W18747595522017 @default.
• W1874759552 countsByYear W18747595522020 @default.
• W1874759552 countsByYear W18747595522021 @default.
• W1874759552 crossrefType "journal-article" @default.
• W1874759552 hasAuthorship W1874759552A5002494168 @default.
• W1874759552 hasAuthorship W1874759552A5004843570 @default.
• W1874759552 hasAuthorship W1874759552A5015137135 @default.
• W1874759552 hasAuthorship W1874759552A5016393405 @default.
• W1874759552 hasAuthorship W1874759552A5037675983 @default.
• W1874759552 hasAuthorship W1874759552A5042471231 @default.
• W1874759552 hasAuthorship W1874759552A5049262839 @default.
• W1874759552 hasAuthorship W1874759552A5049310769 @default.
• W1874759552 hasBestOaLocation W18747595521 @default.
• W1874759552 hasConcept C126322002 @default.
• W1874759552 hasConcept C126894567 @default.
• W1874759552 hasConcept C142724271 @default.
• W1874759552 hasConcept C2779646130 @default.
• W1874759552 hasConcept C2779766728 @default.
• W1874759552 hasConcept C2781156865 @default.
• W1874759552 hasConcept C71924100 @default.
• W1874759552 hasConcept C84393581 @default.
• W1874759552 hasConcept C98274493 @default.
• W1874759552 hasConceptScore W1874759552C126322002 @default.
• W1874759552 hasConceptScore W1874759552C126894567 @default.
• W1874759552 hasConceptScore W1874759552C142724271 @default.
• W1874759552 hasConceptScore W1874759552C2779646130 @default.
• W1874759552 hasConceptScore W1874759552C2779766728 @default.
• W1874759552 hasConceptScore W1874759552C2781156865 @default.
• W1874759552 hasConceptScore W1874759552C71924100 @default.
• W1874759552 hasConceptScore W1874759552C84393581 @default.
• W1874759552 hasConceptScore W1874759552C98274493 @default.
• W1874759552 hasLocation W18747595521 @default.
• W1874759552 hasLocation W18747595522 @default.
• W1874759552 hasLocation W18747595523 @default.
• W1874759552 hasLocation W18747595524 @default.
• W1874759552 hasOpenAccess W1874759552 @default.
• W1874759552 hasPrimaryLocation W18747595521 @default.
• W1874759552 hasRelatedWork W2025586198 @default.
• W1874759552 hasRelatedWork W2027425458 @default.
• W1874759552 hasRelatedWork W2039657099 @default.
• W1874759552 hasRelatedWork W2089173861 @default.
• W1874759552 hasRelatedWork W2124394654 @default.
• W1874759552 hasRelatedWork W2273727769 @default.
• W1874759552 hasRelatedWork W2297918258 @default.
• W1874759552 hasRelatedWork W2348529459 @default.
• W1874759552 hasRelatedWork W2368002165 @default.
• W1874759552 hasRelatedWork W2412535067 @default.
• W1874759552 isParatext "false" @default.
• W1874759552 isRetracted "false" @default.

• next