FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1875199757> ?p ?o ?g. }

• W1875199757 endingPage "542" @default.
• W1875199757 startingPage "530" @default.
• W1875199757 abstract "BackgroundInsulin-like growth factor 1 (IGF1) stimulates mitosis and inhibits apoptosis. Some published results have shown an association between circulating IGF1 and breast-cancer risk, but it has been unclear whether this relationship is consistent or whether it is modified by IGF binding protein 3 (IGFBP3), menopausal status, oestrogen receptor status or other factors. The relationship of IGF1 (and IGFBP3) with breast-cancer risk factors is also unclear. The Endogenous Hormones and Breast Cancer Collaborative Group was established to analyse pooled individual data from prospective studies to increase the precision of the estimated associations of endogenous hormones with breast-cancer risk.MethodsIndividual data on prediagnostic IGF1 and IGFBP3 concentrations were obtained from 17 prospective studies in 12 countries. The associations of IGF1 with risk factors for breast cancer in controls were examined by calculating geometric mean concentrations in categories of these factors. The odds ratios (ORs) with 95% CIs of breast cancer associated with increasing IGF1 concentrations were estimated by conditional logistic regression in 4790 cases and 9428 matched controls, with stratification by study, age at baseline, and date of baseline. All statistical tests were two-sided, and a p value of less than 0·05 was considered significant.FindingsIGF1 concentrations, adjusted for age, were positively associated with height and age at first pregnancy, inversely associated with age at menarche and years since menopause, and were higher in moderately overweight women and moderate alcohol consumers than in other women. The OR for breast cancer for women in the highest versus the lowest fifth of IGF1 concentration was 1·28 (95% CI 1·14–1·44; p<0·0001). This association was not altered by adjusting for IGFBP3, and did not vary significantly by menopausal status at blood collection. The ORs for a difference in IGF1 concentration between the highest and lowest fifth were 1·38 (95% CI 1·14–1·68) for oestrogen-receptor-positive tumours and 0·80 (0·57–1·13) for oestrogen-receptor-negative tumours (p for heterogeneity=0·007).InterpretationCirculating IGF1 is positively associated with breast-cancer risk. The association is not substantially modified by IGFBP3, and does not differ markedly by menopausal status, but seems to be confined to oestrogen-receptor-positive tumours.FundingCancer Research UK." @default.
• W1875199757 created "2016-06-24" @default.
• W1875199757 date "2010-06-01" @default.
• W1875199757 modified "2023-10-16" @default.
• W1875199757 title "Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies" @default.
• W1875199757 cites W1511930757 @default.
• W1875199757 cites W1892460351 @default.
• W1875199757 cites W1919067330 @default.
• W1875199757 cites W1966172424 @default.
• W1875199757 cites W1967425795 @default.
• W1875199757 cites W1975130218 @default.
• W1875199757 cites W1982016422 @default.
• W1875199757 cites W2002389150 @default.
• W1875199757 cites W2006772029 @default.
• W1875199757 cites W2007488022 @default.
• W1875199757 cites W2012505775 @default.
• W1875199757 cites W2017124681 @default.
• W1875199757 cites W2018008896 @default.
• W1875199757 cites W2018280013 @default.
• W1875199757 cites W2019603030 @default.
• W1875199757 cites W2026802581 @default.
• W1875199757 cites W2047490464 @default.
• W1875199757 cites W2047636637 @default.
• W1875199757 cites W2051839343 @default.
• W1875199757 cites W2054339472 @default.
• W1875199757 cites W2072144889 @default.
• W1875199757 cites W2077848651 @default.
• W1875199757 cites W2086673115 @default.
• W1875199757 cites W2087670482 @default.
• W1875199757 cites W2089171551 @default.
• W1875199757 cites W2090929703 @default.
• W1875199757 cites W2097150975 @default.
• W1875199757 cites W2104404830 @default.
• W1875199757 cites W2112025328 @default.
• W1875199757 cites W2114653107 @default.
• W1875199757 cites W2117350664 @default.
• W1875199757 cites W2117530385 @default.
• W1875199757 cites W2119237938 @default.
• W1875199757 cites W2132577252 @default.
• W1875199757 cites W2134973552 @default.
• W1875199757 cites W2139396029 @default.
• W1875199757 cites W2140134061 @default.
• W1875199757 cites W2140764109 @default.
• W1875199757 cites W2148665009 @default.
• W1875199757 cites W2148729042 @default.
• W1875199757 cites W2149575379 @default.
• W1875199757 cites W2161799175 @default.
• W1875199757 cites W2164373820 @default.
• W1875199757 cites W2165120659 @default.
• W1875199757 cites W2169049560 @default.
• W1875199757 cites W2169986092 @default.
• W1875199757 cites W2170539169 @default.
• W1875199757 cites W2182196087 @default.
• W1875199757 cites W2186436769 @default.
• W1875199757 cites W2325290160 @default.
• W1875199757 cites W2399537794 @default.
• W1875199757 cites W257009449 @default.
• W1875199757 doi "https://doi.org/10.1016/s1470-2045(10)70095-4" @default.
• W1875199757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3113287" @default.
• W1875199757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20472501" @default.
• W1875199757 hasPublicationYear "2010" @default.
• W1875199757 type Work @default.
• W1875199757 sameAs 1875199757 @default.
• W1875199757 citedByCount "532" @default.
• W1875199757 countsByYear W18751997572012 @default.
• W1875199757 countsByYear W18751997572013 @default.
• W1875199757 countsByYear W18751997572014 @default.
• W1875199757 countsByYear W18751997572015 @default.
• W1875199757 countsByYear W18751997572016 @default.
• W1875199757 countsByYear W18751997572017 @default.
• W1875199757 countsByYear W18751997572018 @default.
• W1875199757 countsByYear W18751997572019 @default.
• W1875199757 countsByYear W18751997572020 @default.
• W1875199757 countsByYear W18751997572021 @default.
• W1875199757 countsByYear W18751997572022 @default.
• W1875199757 countsByYear W18751997572023 @default.
• W1875199757 crossrefType "journal-article" @default.
• W1875199757 hasBestOaLocation W18751997571 @default.
• W1875199757 hasConcept C121608353 @default.
• W1875199757 hasConcept C126322002 @default.
• W1875199757 hasConcept C134018914 @default.
• W1875199757 hasConcept C143998085 @default.
• W1875199757 hasConcept C156957248 @default.
• W1875199757 hasConcept C170493617 @default.
• W1875199757 hasConcept C186615474 @default.
• W1875199757 hasConcept C188816634 @default.
• W1875199757 hasConcept C2775960820 @default.
• W1875199757 hasConcept C2776601875 @default.
• W1875199757 hasConcept C2778279177 @default.
• W1875199757 hasConcept C2780221984 @default.
• W1875199757 hasConcept C2780586474 @default.
• W1875199757 hasConcept C2780689927 @default.
• W1875199757 hasConcept C29456083 @default.
• W1875199757 hasConcept C42407357 @default.
• W1875199757 hasConcept C50440223 @default.
• W1875199757 hasConcept C530470458 @default.
• W1875199757 hasConcept C71924100 @default.
• W1875199757 hasConceptScore W1875199757C121608353 @default.

• next