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• W1875250937 abstract "Abstract Uncoupling protein 2 (UCP2) belongs to the UCP family, and is distributed in many organs including the brain. Although UCP2 is known to be related to many functions such as the regulation of insulin secretion or the scavenging of the radicals, the role of UCP2 in the central nervous system remains unclear. In this report, rat UCP2 (rUCP2) and its mutants were overexpressed in the PC12h cells to determine the physiological roles played by UCP2 in neural cells and to elucidate the mechanisms that regulate these functions. It was found that rUCP2 was activated by the stimulation of the cAMP‐protein kinase A (PKA) cascade. Moreover, the activation of rUCP2 suppressed intracellular ATP levels and inhibited the cAMP‐dependent increase of dopamine secretion. Thus, UCP2 appears to be regulated by the excitatory stimulus via the cAMP‐PKA cascade and serves to negatively control the synaptic output by reducing intracellular ATP levels." @default.
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• W1875250937 date "2003-09-26" @default.
• W1875250937 modified "2023-10-16" @default.
• W1875250937 title "Uncoupling protein 2 influences dopamine secretion in PC12h cells" @default.
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• W1875250937 doi "https://doi.org/10.1046/j.1471-4159.2003.02005.x" @default.
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