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- W187549356 abstract "This chapter discusses the chemistry, pharmacology, and the biochemistry of apomorphine. Apomorphine (APO) is a tertiary base with the empirical formula C17H17NO2. Its molecular skeleton consists of four fused six-membered rings, giving the molecule a semirigid structure. Its molecular skeleton is that of an aporphine alkaloid; owing to the catechol moiety in ring D, it oxidizes rapidly and becomes green on exposure to air and in solution. APO can be acetylated to diacetylapomorphine without loss of potency. However, etherification leads invariably to less active or inactive compounds. 11-Hydroxy-10-methoxyaporphine (apocodeine) and 10,11-methylenedioxyaporphine are about four times less potent than APO in inducing stereotyped gnawing in rats, while 10,11 -dimethoxyaporphine is inactive. Monohydroxy derivatives of aporphine are inactive. The N-methyl group of 10-or 11-hydroxyaporphine is replaced by a N-n-propyl substituent, some activity is retained; these compounds are nevertheless less potent than APO. It is concluded that the 10, 11-dihydroxy substitution pattern of APO is an absolute requirement for optimal activity." @default.
- W187549356 created "2016-06-24" @default.
- W187549356 creator A5035103700 @default.
- W187549356 creator A5049107618 @default.
- W187549356 creator A5066146195 @default.
- W187549356 date "1976-01-01" @default.
- W187549356 modified "2023-09-28" @default.
- W187549356 title "Apomorphine: Chemistry, Pharmacology, Biochemistry" @default.
- W187549356 cites W11860448 @default.
- W187549356 cites W1552010528 @default.
- W187549356 cites W1562693626 @default.
- W187549356 cites W162270866 @default.
- W187549356 cites W1964582789 @default.
- W187549356 cites W1964638035 @default.
- W187549356 cites W1964877983 @default.
- W187549356 cites W1965262046 @default.
- W187549356 cites W1966207547 @default.
- W187549356 cites W1966958074 @default.
- W187549356 cites W1967672534 @default.
- W187549356 cites W1967751776 @default.
- W187549356 cites W1967984329 @default.
- W187549356 cites W1968008358 @default.
- W187549356 cites W1968369004 @default.
- W187549356 cites W1968551493 @default.
- W187549356 cites W1968588109 @default.
- W187549356 cites W1968967653 @default.
- W187549356 cites W1969473574 @default.
- W187549356 cites W1969523924 @default.
- W187549356 cites W1969717388 @default.
- W187549356 cites W1969804289 @default.
- W187549356 cites W1971122142 @default.
- W187549356 cites W1971162866 @default.
- W187549356 cites W1971701459 @default.
- W187549356 cites W1972647168 @default.
- W187549356 cites W1972918157 @default.
- W187549356 cites W1973264363 @default.
- W187549356 cites W1973979760 @default.
- W187549356 cites W1974828540 @default.
- W187549356 cites W1975272257 @default.
- W187549356 cites W1975675841 @default.
- W187549356 cites W1976271446 @default.
- W187549356 cites W1976342553 @default.
- W187549356 cites W1977247009 @default.
- W187549356 cites W1977347101 @default.
- W187549356 cites W1977383153 @default.
- W187549356 cites W1978004023 @default.
- W187549356 cites W1978540119 @default.
- W187549356 cites W1978714869 @default.
- W187549356 cites W1979539066 @default.
- W187549356 cites W1979619543 @default.
- W187549356 cites W1979729230 @default.
- W187549356 cites W1980104842 @default.
- W187549356 cites W1980275041 @default.
- W187549356 cites W1980836289 @default.
- W187549356 cites W1982564146 @default.
- W187549356 cites W1983662340 @default.
- W187549356 cites W1983739710 @default.
- W187549356 cites W1983883756 @default.
- W187549356 cites W1984070913 @default.
- W187549356 cites W1984255733 @default.
- W187549356 cites W1986075845 @default.
- W187549356 cites W1986269188 @default.
- W187549356 cites W1986962942 @default.
- W187549356 cites W1989702866 @default.
- W187549356 cites W1990340616 @default.
- W187549356 cites W1990501910 @default.
- W187549356 cites W1990592782 @default.
- W187549356 cites W1990671965 @default.
- W187549356 cites W1991721231 @default.
- W187549356 cites W1991817272 @default.
- W187549356 cites W1992174788 @default.
- W187549356 cites W1992401185 @default.
- W187549356 cites W1992754948 @default.
- W187549356 cites W1993160794 @default.
- W187549356 cites W1993220725 @default.
- W187549356 cites W1993477815 @default.
- W187549356 cites W1993553430 @default.
- W187549356 cites W1993582470 @default.
- W187549356 cites W1994539787 @default.
- W187549356 cites W1994611964 @default.
- W187549356 cites W1995671765 @default.
- W187549356 cites W1996594938 @default.
- W187549356 cites W1996644213 @default.
- W187549356 cites W1998646105 @default.
- W187549356 cites W1999331825 @default.
- W187549356 cites W1999402663 @default.
- W187549356 cites W1999723698 @default.
- W187549356 cites W2000481944 @default.
- W187549356 cites W2000593094 @default.
- W187549356 cites W2000962328 @default.
- W187549356 cites W2002417792 @default.
- W187549356 cites W2002527761 @default.
- W187549356 cites W2003151925 @default.
- W187549356 cites W2005313512 @default.
- W187549356 cites W2005595168 @default.
- W187549356 cites W2005673668 @default.
- W187549356 cites W2005781708 @default.
- W187549356 cites W2005968971 @default.