FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1875797879> ?p ?o ?g. }

• W1875797879 abstract "We are investigating a double transgenic rat (dTGR) model, in which rats transgenic for the human angiotensinogen and renin genes are crossed. These rats develop moderately severe hypertension but die of end-organ cardiac and renal damage by week 7. The heart shows necrosis and fibrosis, whereas the kidneys resemble the hemolytic-uremic syndrome vasculopathy. Surface adhesion molecules (ICAM-1 and VCAM-1) are expressed early on the endothelium, while the corresponding ligands are found on circulating leukocytes. Leukocyte infiltration in the vascular wall accompanies PAI-1, MCP-1, iNOS and Tissue Factor expression. Furthermore we show evidence that Ang II causes the upregulation of NF-kB in our model.We started PDTC-treatment on four weeks old dTGR (200 mg/kg sc) and age-matched SD rats. Blood-pressure- and albuminuria- measurements were monitored during the treatment period (four weeks). The seven weeks old animals were killed, hearts and kidneys were isolated and used for immunohistochemical-and electromobility shift assay analysis.Chronic treatment with the antioxidant PDTC decreased blood pressure (162 plus minus 8 vs. 190 plus minus 7 mm Hg, p = 0.02). Cardiac hypertrophy index was significantly reduced (4.90 plus minus 0.1 vs. 5.77 plus minus 0.1 mg/g, p < 0.001) compared to dTGR. PDTC reduced 24 h albuminuria by 85 % (2.7 plus minus 0.5 vs. 18.0 plus minus 3.4 mg/d, p < 0.001) and prevented death significantly. Vascular injury was ameliorated in small renal and cardiac vessels. PDTC inhibited NF-kappaB binding activity in heart and kidney. Immunohistochemical analysis shows increased expression of the p65 NF-kappaB subunit in the endothelium, smooth muscles cells of damaged small vessels, infiltrated cells, glomeruli, tubuli and collecting ducts of dTGR. PDTC markedly reduced the immunoreactivity of p65.Our data show that inhibition of NF-kappaB by PDTC markedly reduces inflammation, iNOS expression in the dTGR most likely leading to decreased cytotoxicity, and cell proliferation. Thus, NF-kappaB activation plays an important role in ANG II-induced end-organ damage." @default.
• W1875797879 created "2016-06-24" @default.
• W1875797879 creator A5005788181 @default.
• W1875797879 creator A5006098867 @default.
• W1875797879 creator A5007174365 @default.
• W1875797879 creator A5008231286 @default.
• W1875797879 creator A5017346227 @default.
• W1875797879 creator A5037320109 @default.
• W1875797879 creator A5046399162 @default.
• W1875797879 creator A5056794023 @default.
• W1875797879 creator A5078018907 @default.
• W1875797879 creator A5081811761 @default.
• W1875797879 date "2002-01-18" @default.
• W1875797879 modified "2023-10-13" @default.
• W1875797879 title "Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats" @default.
• W1875797879 cites W1507147384 @default.
• W1875797879 cites W1554405405 @default.
• W1875797879 cites W1786911182 @default.
• W1875797879 cites W1963289746 @default.
• W1875797879 cites W1964920299 @default.
• W1875797879 cites W1965946150 @default.
• W1875797879 cites W1993761096 @default.
• W1875797879 cites W1995429630 @default.
• W1875797879 cites W2005484362 @default.
• W1875797879 cites W2013216525 @default.
• W1875797879 cites W2020807000 @default.
• W1875797879 cites W2021165648 @default.
• W1875797879 cites W2027566693 @default.
• W1875797879 cites W2027835440 @default.
• W1875797879 cites W2031152693 @default.
• W1875797879 cites W2031524509 @default.
• W1875797879 cites W2041517672 @default.
• W1875797879 cites W2046727158 @default.
• W1875797879 cites W2054054890 @default.
• W1875797879 cites W2065578770 @default.
• W1875797879 cites W2077741802 @default.
• W1875797879 cites W2094199657 @default.
• W1875797879 cites W2097424152 @default.
• W1875797879 cites W2103687576 @default.
• W1875797879 cites W2106004501 @default.
• W1875797879 cites W2131924126 @default.
• W1875797879 cites W2137630689 @default.
• W1875797879 cites W2139328513 @default.
• W1875797879 cites W2140106465 @default.
• W1875797879 cites W2142541950 @default.
• W1875797879 cites W2149097315 @default.
• W1875797879 cites W2151577160 @default.
• W1875797879 cites W2157944478 @default.
• W1875797879 cites W2159567970 @default.
• W1875797879 cites W2163707326 @default.
• W1875797879 cites W2169878907 @default.
• W1875797879 cites W2318993770 @default.
• W1875797879 cites W2331176038 @default.
• W1875797879 cites W2415196759 @default.
• W1875797879 cites W2613483874 @default.
• W1875797879 cites W4313341332 @default.
• W1875797879 doi "https://doi.org/10.1186/1471-2261-2-3" @default.
• W1875797879 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/65512" @default.
• W1875797879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11835691" @default.
• W1875797879 hasPublicationYear "2002" @default.
• W1875797879 type Work @default.
• W1875797879 sameAs 1875797879 @default.
• W1875797879 citedByCount "72" @default.
• W1875797879 countsByYear W18757978792012 @default.
• W1875797879 countsByYear W18757978792014 @default.
• W1875797879 countsByYear W18757978792015 @default.
• W1875797879 countsByYear W18757978792016 @default.
• W1875797879 countsByYear W18757978792017 @default.
• W1875797879 countsByYear W18757978792019 @default.
• W1875797879 countsByYear W18757978792020 @default.
• W1875797879 countsByYear W18757978792022 @default.
• W1875797879 crossrefType "journal-article" @default.
• W1875797879 hasAuthorship W1875797879A5005788181 @default.
• W1875797879 hasAuthorship W1875797879A5006098867 @default.
• W1875797879 hasAuthorship W1875797879A5007174365 @default.
• W1875797879 hasAuthorship W1875797879A5008231286 @default.
• W1875797879 hasAuthorship W1875797879A5017346227 @default.
• W1875797879 hasAuthorship W1875797879A5037320109 @default.
• W1875797879 hasAuthorship W1875797879A5046399162 @default.
• W1875797879 hasAuthorship W1875797879A5056794023 @default.
• W1875797879 hasAuthorship W1875797879A5078018907 @default.
• W1875797879 hasAuthorship W1875797879A5081811761 @default.
• W1875797879 hasBestOaLocation W18757978791 @default.
• W1875797879 hasConcept C126322002 @default.
• W1875797879 hasConcept C134018914 @default.
• W1875797879 hasConcept C167414201 @default.
• W1875797879 hasConcept C2776174234 @default.
• W1875797879 hasConcept C2776914184 @default.
• W1875797879 hasConcept C2780091579 @default.
• W1875797879 hasConcept C2780559512 @default.
• W1875797879 hasConcept C2908929049 @default.
• W1875797879 hasConcept C71924100 @default.
• W1875797879 hasConcept C84393581 @default.
• W1875797879 hasConceptScore W1875797879C126322002 @default.
• W1875797879 hasConceptScore W1875797879C134018914 @default.
• W1875797879 hasConceptScore W1875797879C167414201 @default.
• W1875797879 hasConceptScore W1875797879C2776174234 @default.
• W1875797879 hasConceptScore W1875797879C2776914184 @default.
• W1875797879 hasConceptScore W1875797879C2780091579 @default.
• W1875797879 hasConceptScore W1875797879C2780559512 @default.

• next