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- W187582919 abstract "Investigations over many years have repeatedly drawn attention to the question of what — if anything — is the biological significance of the disulfide grouping in neurohypophyseal hormones. Two groups of analogs appear to be of special interest in this connection: [1] derivatives lacking both the disulfide grouping and the cyclic component of the molecule (1–8) and [2] derivatives lacking the disulfide grouping but retaining the cyclic component of the molecule (9–11). To gain deeper insight into the function of the disulfide bridge as a unit and to explore the function of each sulfur center individually, one or both of the sulfur atoms was replaced in oxytocin and deamino-oxytocin by selenium atoms (12–14) and the resultant selenium-containing analogs are being studied by chemical, physical and pharmacological methods." @default.
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- W187582919 date "1968-01-01" @default.
- W187582919 modified "2023-09-27" @default.
- W187582919 title "Comparison of the Pharmacological Properties of Two Highly Potent, Crystalline Neurohypophyseal Hormone Analogs: Deamino-1-Seleno-Oxytocin and Deamino-Oxytocin" @default.
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- W187582919 doi "https://doi.org/10.1007/978-1-4614-4612-5_13" @default.
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