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- W187584605 abstract "Vascular calcification is a well-known complication of chronic kidney disease and one of the main predictors for increased cardiovascular morbidity and mortality in these patients. It may happen in 2 main types of intimal calcification, as a part of diffuse atherosclerosis, and medial calcification, which is generally focal in distribution, unrelated to atherosclerotic risk factors, and seen in younger hemodialysis patients. Pathogenesis may be genetic, mineral metabolism related, or nonmineral metabolism related. Increased calcium, phosphorus, and calcium- phosphorus product; decreased parathyroid hormone level; and overzealous use of active vitamin D supplements are the main mineral metabolism-related mechanisms of vascular calcification. Other mechanisms are formation of matrix vesicles and cellular apoptosis, with generation of hydroxyapatite crystals within vesicles and apoptotic bodies. The interplay of various activator proteins of vascular calcification such as bone morphogenetic proteins and receptor activator of nuclear factor-kappa B ligand, or inhibitor proteins like matrix Gla protein, bone morphogenetic protein-7, osteopontin, osteoprotegerin, fetuin-A, Smad6, and pyrophosphate are important in establishment of vascular calcification. Vascular calcification is related to all-cause and cardiovascular mortality both in general population and dialysis patients. Minimizing traditional risk factors of vascular calcification, prevention of hypercalcemia, and avoidance of high doses of calcium-based phosphate binders and vitamin D analogues are important measures for prevention or attenuation of progression of vascular calcification. Sevelamer and cinacalcet may prevent progression of vascular calcification. With the evolving knowledge of the pathogenesis of vascular calcification, we can look forward to emergence of novel therapies for this complication in the future." @default.
- W187584605 created "2016-06-24" @default.
- W187584605 creator A5005197147 @default.
- W187584605 date "2011-09-01" @default.
- W187584605 modified "2023-09-23" @default.
- W187584605 title "Vascular calcification in chronic kidney disease: mechanisms and clinical implications." @default.
- W187584605 cites W116790959 @default.
- W187584605 cites W142085797 @default.
- W187584605 cites W1532662445 @default.
- W187584605 cites W1553842116 @default.
- W187584605 cites W1561751527 @default.
- W187584605 cites W1713906157 @default.
- W187584605 cites W1912237646 @default.
- W187584605 cites W1931287781 @default.
- W187584605 cites W1945199177 @default.
- W187584605 cites W1945450223 @default.
- W187584605 cites W1965477385 @default.
- W187584605 cites W1966120281 @default.
- W187584605 cites W1967270030 @default.
- W187584605 cites W1967330581 @default.
- W187584605 cites W1967345257 @default.
- W187584605 cites W1968804919 @default.
- W187584605 cites W1970366992 @default.
- W187584605 cites W1970501337 @default.
- W187584605 cites W1973207565 @default.
- W187584605 cites W1973870305 @default.
- W187584605 cites W1973948354 @default.
- W187584605 cites W1974287326 @default.
- W187584605 cites W1974940278 @default.
- W187584605 cites W1978456616 @default.
- W187584605 cites W1979587730 @default.
- W187584605 cites W1979847078 @default.
- W187584605 cites W1980042544 @default.
- W187584605 cites W1982937352 @default.
- W187584605 cites W1983946999 @default.
- W187584605 cites W1987244275 @default.
- W187584605 cites W1987372995 @default.
- W187584605 cites W1987561858 @default.
- W187584605 cites W1991055135 @default.
- W187584605 cites W1993330966 @default.
- W187584605 cites W2000447929 @default.
- W187584605 cites W2000458563 @default.
- W187584605 cites W2000647744 @default.
- W187584605 cites W2003123296 @default.
- W187584605 cites W2005172273 @default.
- W187584605 cites W2008032729 @default.
- W187584605 cites W2014259599 @default.
- W187584605 cites W2016052320 @default.
- W187584605 cites W2016637403 @default.
- W187584605 cites W2017043161 @default.
- W187584605 cites W2017912935 @default.
- W187584605 cites W2019766768 @default.
- W187584605 cites W2025136911 @default.
- W187584605 cites W2028210116 @default.
- W187584605 cites W2030777261 @default.
- W187584605 cites W2032247511 @default.
- W187584605 cites W2032738367 @default.
- W187584605 cites W2034712955 @default.
- W187584605 cites W2037165324 @default.
- W187584605 cites W2044969311 @default.
- W187584605 cites W2045847718 @default.
- W187584605 cites W2050277287 @default.
- W187584605 cites W2052910631 @default.
- W187584605 cites W2054323843 @default.
- W187584605 cites W2054582400 @default.
- W187584605 cites W2058338941 @default.
- W187584605 cites W2058579856 @default.
- W187584605 cites W2062776506 @default.
- W187584605 cites W2063679628 @default.
- W187584605 cites W2065254627 @default.
- W187584605 cites W2073485308 @default.
- W187584605 cites W2075554523 @default.
- W187584605 cites W2076904776 @default.
- W187584605 cites W2078017376 @default.
- W187584605 cites W2078966370 @default.
- W187584605 cites W2082178761 @default.
- W187584605 cites W2084789695 @default.
- W187584605 cites W2086534014 @default.
- W187584605 cites W2090329451 @default.
- W187584605 cites W2095804181 @default.
- W187584605 cites W2096024580 @default.
- W187584605 cites W2097229179 @default.
- W187584605 cites W2097354630 @default.
- W187584605 cites W2097971682 @default.
- W187584605 cites W2101385628 @default.
- W187584605 cites W2102938488 @default.
- W187584605 cites W2103566243 @default.
- W187584605 cites W2105024958 @default.
- W187584605 cites W2110653967 @default.
- W187584605 cites W2113308396 @default.
- W187584605 cites W2114164409 @default.
- W187584605 cites W2114360920 @default.
- W187584605 cites W2115561522 @default.
- W187584605 cites W2116197354 @default.
- W187584605 cites W2118835331 @default.
- W187584605 cites W2119501410 @default.
- W187584605 cites W2119726734 @default.
- W187584605 cites W2120166750 @default.