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• W1875894773 endingPage "1187" @default.
• W1875894773 startingPage "1173" @default.
• W1875894773 abstract "Summary In Streptomyces griseus , A‐factor (2‐isocapryloyl‐3 R ‐hydroxymethyl‐γ‐butyrolactone) acts as a chemical signalling molecule that triggers morphological differentiation and secondary metabolism. A transcriptional activator, AdpA, in the A‐factor regulatory cascade switches on a number of genes required for both processes, thus forming an AdpA regulon. amfR encoding a regulatory protein similar to response regulators of bacterial two‐component regulatory systems and essential for aerial mycelium formation was found to be a member of the AdpA regulon. AdpA bound two sites at nucleotide positions approximately −200 (site 1) and −60 (site 2), with respect to the major transcriptional start point of amfR , and accelerated the transcription of amfR by assisting RNA polymerase in forming an open complex at an appropriate region including the transcriptional start point. Site 2 contributed more to the transcriptional activation of amfR by AdpA than site 1, although AdpA showed a much lower affinity to site 2 than to site 1. The amfR transcription enhanced by AdpA subsequently ceased at day 2 when aerial hyphae began to be formed in the wild‐type strain, whereas in an adsA null mutant amfR was continuously transcribed even until day 3. This implied that amfR was repressed growth dependently by a gene product under the control of σ‐AdsA. Transcription of the promoter upstream of amfT depended on amfR , which is consistent with the idea that AmfR serves as an activator for amfTSBA in the amf operon. The observations that the amfR gene contains a TTA codon, a potential target for bldA ‐mediated regulation, and a conserved Asp‐54 residue, which might be phosphorylated by a sensor kinase, suggest that the amf operon is under transcriptional, translational and post‐translational control systems." @default.
• W1875894773 created "2016-06-24" @default.
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• W1875894773 creator A5063925719 @default.
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• W1875894773 date "2003-11-01" @default.
• W1875894773 modified "2023-10-15" @default.
• W1875894773 title "amfR, an essential gene for aerial mycelium formation, is a member of the AdpA regulon in the A-factor regulatory cascade in Streptomyces griseus" @default.
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• W1875894773 doi "https://doi.org/10.1046/j.1365-2958.2003.03760.x" @default.
• W1875894773 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14622407" @default.
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