FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1875960097> ?p ?o ?g. }

• W1875960097 endingPage "468" @default.
• W1875960097 startingPage "463" @default.
• W1875960097 abstract "The antibody response in trichomoniasis patients was examined with a variety of methodologies including enzyme-linked immunosorbent assays, indirect immunofluorescence, immunoblotting, and radioimmunoprecipitation-electrophoresis-autoradiography. Based on enzyme-linked immunosorbent assay recognition of trichomonal isolates, sera from patients with trichomoniasis were categorized into reactive class I (IA, IB, and IC) and nonreactive class II sera. A diminished ability to precipitate antibody-binding trichomonad membrane proteins by the whole cell radioimmunoprecipitation assay was noted from class IA to class II sera. The antigenic distinctions among various Trichomonas vaginalis isolates appeared due to high-molecular-weight protein antigens detected by class IA sera in a whole cell radioimmunoprecipitation assay. The heterogeneity in antigenic patterns was confirmed among the isolates with sera from experimental animals. Also, live T. vaginalis cells appear to have only a few of the entire repertoire of major immunogenic surface proteins accessible to antibody binding. Immunoblotting demonstrated that the high-molecular-weight proteins responsible for trichomonal isolate heterogeneity are present in all isolates. The data suggest that trichomonads of a given isolate express only a subset of internally synthesized protein antigens on their surface. Importantly, the presence of these protein antigens on T. vaginalis membranes correlated with antibody production in subcutaneously challenged mice. Finally, indirect immunofluorescence studies with highly reactive, pooled sera from either patients or mice revealed a subpopulation of nonstaining trichomonads. These data support the view that heterogeneity among T. vaginalis is dependent upon the surface disposition of highly immunogenic protein antigens. Strategies may now be developed not only for studying potential vaccine reagents, but also for examining possible antigenic phenotypic variations in this experimental model." @default.
• W1875960097 created "2016-06-24" @default.
• W1875960097 creator A5006372711 @default.
• W1875960097 creator A5056252369 @default.
• W1875960097 creator A5068006421 @default.
• W1875960097 creator A5070535562 @default.
• W1875960097 creator A5071656219 @default.
• W1875960097 date "1985-09-01" @default.
• W1875960097 modified "2023-09-26" @default.
• W1875960097 title "Heterogeneity of Trichomonas vaginalis and discrimination among trichomonal isolates and subpopulations with sera of patients and experimentally infected mice" @default.
• W1875960097 cites W1751955717 @default.
• W1875960097 cites W1854834598 @default.
• W1875960097 cites W1906650683 @default.
• W1875960097 cites W1920863429 @default.
• W1875960097 cites W1950452144 @default.
• W1875960097 cites W1953159355 @default.
• W1875960097 cites W1964208524 @default.
• W1875960097 cites W1971840298 @default.
• W1875960097 cites W1999447321 @default.
• W1875960097 cites W2047478018 @default.
• W1875960097 cites W2060529878 @default.
• W1875960097 cites W2082142246 @default.
• W1875960097 cites W2087996659 @default.
• W1875960097 cites W2114245487 @default.
• W1875960097 cites W2120717359 @default.
• W1875960097 cites W2155179635 @default.
• W1875960097 cites W2314381015 @default.
• W1875960097 cites W2343967413 @default.
• W1875960097 doi "https://doi.org/10.1128/iai.49.3.463-468.1985" @default.
• W1875960097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/261183" @default.
• W1875960097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2411656" @default.
• W1875960097 hasPublicationYear "1985" @default.
• W1875960097 type Work @default.
• W1875960097 sameAs 1875960097 @default.
• W1875960097 citedByCount "49" @default.
• W1875960097 countsByYear W18759600972012 @default.
• W1875960097 countsByYear W18759600972014 @default.
• W1875960097 countsByYear W18759600972015 @default.
• W1875960097 countsByYear W18759600972023 @default.
• W1875960097 crossrefType "journal-article" @default.
• W1875960097 hasAuthorship W1875960097A5006372711 @default.
• W1875960097 hasAuthorship W1875960097A5056252369 @default.
• W1875960097 hasAuthorship W1875960097A5068006421 @default.
• W1875960097 hasAuthorship W1875960097A5070535562 @default.
• W1875960097 hasAuthorship W1875960097A5071656219 @default.
• W1875960097 hasBestOaLocation W18759600971 @default.
• W1875960097 hasConcept C142724271 @default.
• W1875960097 hasConcept C147483822 @default.
• W1875960097 hasConcept C159047783 @default.
• W1875960097 hasConcept C159654299 @default.
• W1875960097 hasConcept C203014093 @default.
• W1875960097 hasConcept C2777023796 @default.
• W1875960097 hasConcept C2778236600 @default.
• W1875960097 hasConcept C2778566189 @default.
• W1875960097 hasConcept C2779397712 @default.
• W1875960097 hasConcept C2781114625 @default.
• W1875960097 hasConcept C71924100 @default.
• W1875960097 hasConcept C86803240 @default.
• W1875960097 hasConcept C89423630 @default.
• W1875960097 hasConceptScore W1875960097C142724271 @default.
• W1875960097 hasConceptScore W1875960097C147483822 @default.
• W1875960097 hasConceptScore W1875960097C159047783 @default.
• W1875960097 hasConceptScore W1875960097C159654299 @default.
• W1875960097 hasConceptScore W1875960097C203014093 @default.
• W1875960097 hasConceptScore W1875960097C2777023796 @default.
• W1875960097 hasConceptScore W1875960097C2778236600 @default.
• W1875960097 hasConceptScore W1875960097C2778566189 @default.
• W1875960097 hasConceptScore W1875960097C2779397712 @default.
• W1875960097 hasConceptScore W1875960097C2781114625 @default.
• W1875960097 hasConceptScore W1875960097C71924100 @default.
• W1875960097 hasConceptScore W1875960097C86803240 @default.
• W1875960097 hasConceptScore W1875960097C89423630 @default.
• W1875960097 hasIssue "3" @default.
• W1875960097 hasLocation W18759600971 @default.
• W1875960097 hasLocation W18759600972 @default.
• W1875960097 hasLocation W18759600973 @default.
• W1875960097 hasOpenAccess W1875960097 @default.
• W1875960097 hasPrimaryLocation W18759600971 @default.
• W1875960097 hasRelatedWork W1602097275 @default.
• W1875960097 hasRelatedWork W1875960097 @default.
• W1875960097 hasRelatedWork W1899999397 @default.
• W1875960097 hasRelatedWork W1978212860 @default.
• W1875960097 hasRelatedWork W2046652289 @default.
• W1875960097 hasRelatedWork W2096768374 @default.
• W1875960097 hasRelatedWork W2410420462 @default.
• W1875960097 hasRelatedWork W2419307296 @default.
• W1875960097 hasRelatedWork W2468597331 @default.
• W1875960097 hasRelatedWork W72755888 @default.
• W1875960097 hasVolume "49" @default.
• W1875960097 isParatext "false" @default.
• W1875960097 isRetracted "false" @default.
• W1875960097 magId "1875960097" @default.
• W1875960097 workType "article" @default.