FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1876019739> ?p ?o ?g. }

• W1876019739 endingPage "249" @default.
• W1876019739 startingPage "239" @default.
• W1876019739 abstract "Abstract Evolutionary analysis of codon bias in Drosophila indicates that synonymous mutations are not neutral, but rather are subject to weak selection at the translation level. Here we show that the effectiveness of natural selection on synonymous sites is strongly correlated with the rate of recombination, in accord with the nearly neutral hypothesis. This correlation, however, is apparent only in genes encoding short proteins. Long coding regions have both a lower codon bias and higher synonymous substitution rates, suggesting that they are affected less efficiently by selection. Therefore, both the length of the coding region and the recombination rate modulate codon bias. In addition, the data indicate that selection coefficients for synonymous mutations must vary by a minimum of one or two orders of magnitude. Two hypotheses are proposed to explain the relationship among the coding region length, the codon bias, and the synonymous divergence and polymorphism levels across the range of recombination rates in Drosophila. The first hypothesis is that selection coefficients on synonymous mutations are inversely related to the total length of the coding region. The second hypothesis proposes that interference among synonymous mutations reduces the efficacy of selection on these mutations. We investigated this second hypothesis by carrying out forward simulations of weakly selected mutations in model populations. These simulations show that even with realistic recombination rates, this interference, which we call the “small-scale” Hill-Robertson effect, can have a moderately strong influence on codon bias." @default.
• W1876019739 created "2016-06-24" @default.
• W1876019739 creator A5008576882 @default.
• W1876019739 creator A5069922185 @default.
• W1876019739 creator A5084572289 @default.
• W1876019739 date "1999-01-01" @default.
• W1876019739 modified "2023-10-12" @default.
• W1876019739 title "Natural Selection on Synonymous Sites Is Correlated With Gene Length and Recombination in Drosophila" @default.
• W1876019739 cites W144512190 @default.
• W1876019739 cites W1603411458 @default.
• W1876019739 cites W1777817130 @default.
• W1876019739 cites W1826850017 @default.
• W1876019739 cites W1898487480 @default.
• W1876019739 cites W1901458113 @default.
• W1876019739 cites W1908834636 @default.
• W1876019739 cites W1932538605 @default.
• W1876019739 cites W1940662708 @default.
• W1876019739 cites W1945308210 @default.
• W1876019739 cites W1965996005 @default.
• W1876019739 cites W1970218405 @default.
• W1876019739 cites W1988090113 @default.
• W1876019739 cites W1990167324 @default.
• W1876019739 cites W1990442358 @default.
• W1876019739 cites W1990839617 @default.
• W1876019739 cites W1991480269 @default.
• W1876019739 cites W1997170579 @default.
• W1876019739 cites W2004146038 @default.
• W1876019739 cites W2004674004 @default.
• W1876019739 cites W2005058463 @default.
• W1876019739 cites W2014673667 @default.
• W1876019739 cites W2019604065 @default.
• W1876019739 cites W2026139443 @default.
• W1876019739 cites W2027059027 @default.
• W1876019739 cites W2028165934 @default.
• W1876019739 cites W2038941962 @default.
• W1876019739 cites W2044961839 @default.
• W1876019739 cites W2051043527 @default.
• W1876019739 cites W2065120930 @default.
• W1876019739 cites W2067361082 @default.
• W1876019739 cites W2083365573 @default.
• W1876019739 cites W2089434733 @default.
• W1876019739 cites W2108031707 @default.
• W1876019739 cites W2114900973 @default.
• W1876019739 cites W2117190061 @default.
• W1876019739 cites W2126204254 @default.
• W1876019739 cites W2127460328 @default.
• W1876019739 cites W2130315111 @default.
• W1876019739 cites W2132060660 @default.
• W1876019739 cites W2135101175 @default.
• W1876019739 cites W2147126179 @default.
• W1876019739 cites W2147891536 @default.
• W1876019739 cites W2157848631 @default.
• W1876019739 cites W2159504960 @default.
• W1876019739 cites W2188845178 @default.
• W1876019739 cites W2324849642 @default.
• W1876019739 cites W2341901469 @default.
• W1876019739 cites W281270647 @default.
• W1876019739 cites W3012079654 @default.
• W1876019739 cites W4230982954 @default.
• W1876019739 cites W4232591682 @default.
• W1876019739 cites W4251304755 @default.
• W1876019739 doi "https://doi.org/10.1093/genetics/151.1.239" @default.
• W1876019739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1460462" @default.
• W1876019739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9872963" @default.
• W1876019739 hasPublicationYear "1999" @default.
• W1876019739 type Work @default.
• W1876019739 sameAs 1876019739 @default.
• W1876019739 citedByCount "251" @default.
• W1876019739 countsByYear W18760197392012 @default.
• W1876019739 countsByYear W18760197392013 @default.
• W1876019739 countsByYear W18760197392014 @default.
• W1876019739 countsByYear W18760197392015 @default.
• W1876019739 countsByYear W18760197392016 @default.
• W1876019739 countsByYear W18760197392017 @default.
• W1876019739 countsByYear W18760197392018 @default.
• W1876019739 countsByYear W18760197392019 @default.
• W1876019739 countsByYear W18760197392020 @default.
• W1876019739 countsByYear W18760197392021 @default.
• W1876019739 countsByYear W18760197392022 @default.
• W1876019739 countsByYear W18760197392023 @default.
• W1876019739 crossrefType "journal-article" @default.
• W1876019739 hasAuthorship W1876019739A5008576882 @default.
• W1876019739 hasAuthorship W1876019739A5069922185 @default.
• W1876019739 hasAuthorship W1876019739A5084572289 @default.
• W1876019739 hasBestOaLocation W18760197391 @default.
• W1876019739 hasConcept C104317684 @default.
• W1876019739 hasConcept C138025448 @default.
• W1876019739 hasConcept C141231307 @default.
• W1876019739 hasConcept C149129301 @default.
• W1876019739 hasConcept C154945302 @default.
• W1876019739 hasConcept C156695909 @default.
• W1876019739 hasConcept C1570309 @default.
• W1876019739 hasConcept C166393388 @default.
• W1876019739 hasConcept C195491092 @default.
• W1876019739 hasConcept C41008148 @default.
• W1876019739 hasConcept C42251679 @default.
• W1876019739 hasConcept C501734568 @default.
• W1876019739 hasConcept C54355233 @default.

• next