FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1876061750> ?p ?o ?g. }

• W1876061750 endingPage "246" @default.
• W1876061750 startingPage "229" @default.
• W1876061750 abstract "Significance: Integrins are bidirectional signaling receptors for extracellular matrix that regulate both inside-out signaling that controls keratinocyte-mediated changes to the wound microenvironment and outside-in signaling that controls keratinocyte responses to microenvironmental changes. As such, integrins represent attractive therapeutic targets for treatment of chronic wounds or general promotion of wound healing. Advances in wound management are particularly important as the elderly and diabetic populations within the United States continue to grow. Recent Advances: Although integrins are best known for mediating cell adhesion and migration, integrins in wound epidermis also control cell survival, proliferation, matrix remodeling, and paracrine crosstalk to other cellular compartments of the wound. Importantly, the concept of targeting integrins in the clinic has been established for treatment of certain cancers and other diseases, laying the groundwork for similar exploitation of integrins as targets to treat chronic wounds. Critical Issues: Despite their attractiveness as therapeutic targets, integrins have complex roles in wound healing that are impacted by both their own expression and a highly dynamic wound microenvironment that determines ligand availability. Therefore, identifying relevant integrin ligands in the wound and understanding both distinct and overlapping functions that different integrins play in the epidermis will be critical to determine their precise roles in wound healing. Future Directions: Future research should focus on gaining a thorough understanding of the highly coordinated functions of different integrins in wound epidermis, and on determining which of these functions go awry in pathological wounds. This focus should facilitate development of integrin-targeting therapeutics for treating chronic wounds." @default.
• W1876061750 created "2016-06-24" @default.
• W1876061750 creator A5044569114 @default.
• W1876061750 creator A5054354487 @default.
• W1876061750 date "2014-03-01" @default.
• W1876061750 modified "2023-10-17" @default.
• W1876061750 title "Integrin Regulation of Epidermal Functions in Wounds" @default.
• W1876061750 cites W1533970263 @default.
• W1876061750 cites W1574172480 @default.
• W1876061750 cites W1574213882 @default.
• W1876061750 cites W1576773659 @default.
• W1876061750 cites W1577573926 @default.
• W1876061750 cites W157839118 @default.
• W1876061750 cites W1674001762 @default.
• W1876061750 cites W1835561921 @default.
• W1876061750 cites W1905978178 @default.
• W1876061750 cites W1908004582 @default.
• W1876061750 cites W1924064381 @default.
• W1876061750 cites W1942941883 @default.
• W1876061750 cites W1949832432 @default.
• W1876061750 cites W1964588019 @default.
• W1876061750 cites W1969342647 @default.
• W1876061750 cites W1970559721 @default.
• W1876061750 cites W1970578976 @default.
• W1876061750 cites W1970651122 @default.
• W1876061750 cites W1970858060 @default.
• W1876061750 cites W1975142493 @default.
• W1876061750 cites W1975718597 @default.
• W1876061750 cites W1977602054 @default.
• W1876061750 cites W1980923037 @default.
• W1876061750 cites W1984274933 @default.
• W1876061750 cites W1986301169 @default.
• W1876061750 cites W1986958075 @default.
• W1876061750 cites W1989046246 @default.
• W1876061750 cites W1990084142 @default.
• W1876061750 cites W1996059365 @default.
• W1876061750 cites W1997830990 @default.
• W1876061750 cites W1998777645 @default.
• W1876061750 cites W1998975199 @default.
• W1876061750 cites W2000973090 @default.
• W1876061750 cites W2001171764 @default.
• W1876061750 cites W2001296918 @default.
• W1876061750 cites W2001493281 @default.
• W1876061750 cites W2004459318 @default.
• W1876061750 cites W2005918089 @default.
• W1876061750 cites W2011202983 @default.
• W1876061750 cites W2012491088 @default.
• W1876061750 cites W2014407412 @default.
• W1876061750 cites W2018822666 @default.
• W1876061750 cites W2020283231 @default.
• W1876061750 cites W2024651104 @default.
• W1876061750 cites W2025047729 @default.
• W1876061750 cites W2026289034 @default.
• W1876061750 cites W2026897875 @default.
• W1876061750 cites W2029675195 @default.
• W1876061750 cites W2031836276 @default.
• W1876061750 cites W2032554052 @default.
• W1876061750 cites W2032879380 @default.
• W1876061750 cites W2035198108 @default.
• W1876061750 cites W2035553802 @default.
• W1876061750 cites W2037598346 @default.
• W1876061750 cites W2041400374 @default.
• W1876061750 cites W2041795914 @default.
• W1876061750 cites W2045262799 @default.
• W1876061750 cites W2045702433 @default.
• W1876061750 cites W2047749946 @default.
• W1876061750 cites W2048550241 @default.
• W1876061750 cites W2048845152 @default.
• W1876061750 cites W2051570308 @default.
• W1876061750 cites W2052264968 @default.
• W1876061750 cites W2054297426 @default.
• W1876061750 cites W2055721324 @default.
• W1876061750 cites W2058009094 @default.
• W1876061750 cites W2060178520 @default.
• W1876061750 cites W2060370047 @default.
• W1876061750 cites W2062760663 @default.
• W1876061750 cites W2063186096 @default.
• W1876061750 cites W2063220206 @default.
• W1876061750 cites W2064538798 @default.
• W1876061750 cites W2064961793 @default.
• W1876061750 cites W2066570934 @default.
• W1876061750 cites W2070207385 @default.
• W1876061750 cites W2071359561 @default.
• W1876061750 cites W2072755205 @default.
• W1876061750 cites W2075560919 @default.
• W1876061750 cites W2075965099 @default.
• W1876061750 cites W2076971256 @default.
• W1876061750 cites W2077693542 @default.
• W1876061750 cites W2087118297 @default.
• W1876061750 cites W2087342203 @default.
• W1876061750 cites W2087413829 @default.
• W1876061750 cites W2087963453 @default.
• W1876061750 cites W2088210106 @default.
• W1876061750 cites W2089089955 @default.
• W1876061750 cites W2089747862 @default.
• W1876061750 cites W2091905495 @default.
• W1876061750 cites W2092447350 @default.
• W1876061750 cites W2092716316 @default.

• next