FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1876152197> ?p ?o ?g. }

• W1876152197 endingPage "318" @default.
• W1876152197 startingPage "309" @default.
• W1876152197 abstract "<b><i>Background:</i></b> The CHInese Medicine NeuroAiD Efficacy on Stroke recovery (CHIMES) study was an international randomized double-blind placebo-controlled trial of MLC601 (NeuroAiD) in subjects with cerebral infarction of intermediate severity within 72 h. CHIMES-E (Extension) aimed at evaluating the effects of the initial 3-month treatment with MLC601 on long-term outcome for up to 2 years. <b><i>Methods:</i></b> All subjects randomized in CHIMES were eligible for CHIMES-E. Inclusion criteria for CHIMES were age ≥18, baseline National Institute of Health Stroke Scale of 6-14, and pre-stroke modified Rankin Scale (mRS) ≤1. Initial CHIMES treatment allocation blinding was maintained, although no further study treatment was provided in CHIMES-E. Subjects received standard care and rehabilitation as prescribed by the treating physician. mRS, Barthel Index (BI), and occurrence of medical events were ascertained at months 6, 12, 18, and 24. The primary outcome was mRS at 24 months. Secondary outcomes were mRS and BI at other time points. <b><i>Results:</i></b> CHIMES-E included 880 subjects (mean age 61.8 ± 11.3; 36% women). Adjusted OR for mRS ordinal analysis was 1.08 (95% CI 0.85-1.37, p = 0.543) and mRS dichotomy ≤1 was 1.29 (95% CI 0.96-1.74, p = 0.093) at 24 months. However, the treatment effect was significantly in favor of MLC601 for mRS dichotomy ≤1 at 6 months (OR 1.49, 95% CI 1.11-2.01, p = 0.008), 12 months (OR 1.41, 95% CI 1.05-1.90, p = 0.023), and 18 months (OR 1.36, 95% CI 1.01-1.83, p = 0.045), and for BI dichotomy ≥95 at 6 months (OR 1.55, 95% CI 1.14-2.10, p = 0.005) but not at other time points. Subgroup analyses showed no treatment heterogeneity. Rates of death and occurrence of vascular and other medical events were similar between groups. <b><i>Conclusions:</i></b> While the benefits of a 3-month treatment with MLC601 did not reach statistical significance for the primary endpoint at 2 years, the odds of functional independence defined as mRS ≤1 was significantly increased at 6 months and persisted up to 18 months after a stroke." @default.
• W1876152197 created "2016-06-24" @default.
• W1876152197 creator A5008989080 @default.
• W1876152197 creator A5016751794 @default.
• W1876152197 creator A5017191850 @default.
• W1876152197 creator A5020634811 @default.
• W1876152197 creator A5021993357 @default.
• W1876152197 creator A5022789521 @default.
• W1876152197 creator A5024660718 @default.
• W1876152197 creator A5034374147 @default.
• W1876152197 creator A5037238963 @default.
• W1876152197 creator A5038328686 @default.
• W1876152197 creator A5044191654 @default.
• W1876152197 creator A5053578374 @default.
• W1876152197 creator A5058387399 @default.
• W1876152197 creator A5062096569 @default.
• W1876152197 creator A5062431717 @default.
• W1876152197 creator A5063809392 @default.
• W1876152197 creator A5072660015 @default.
• W1876152197 creator A5074316574 @default.
• W1876152197 creator A5082123632 @default.
• W1876152197 creator A5082699305 @default.
• W1876152197 creator A5087161674 @default.
• W1876152197 creator A5088279024 @default.
• W1876152197 date "2015-01-01" @default.
• W1876152197 modified "2023-10-18" @default.
• W1876152197 title "CHInese Medicine NeuroAiD Efficacy on Stroke Recovery - Extension Study (CHIMES-E): A Multicenter Study of Long-Term Efficacy" @default.
• W1876152197 cites W1480494249 @default.
• W1876152197 cites W1511605526 @default.
• W1876152197 cites W1521155577 @default.
• W1876152197 cites W186716551 @default.
• W1876152197 cites W1966822119 @default.
• W1876152197 cites W1969369520 @default.
• W1876152197 cites W1969661146 @default.
• W1876152197 cites W1981093239 @default.
• W1876152197 cites W1981990510 @default.
• W1876152197 cites W1982829837 @default.
• W1876152197 cites W1991217794 @default.
• W1876152197 cites W2001988332 @default.
• W1876152197 cites W2011783556 @default.
• W1876152197 cites W2019588794 @default.
• W1876152197 cites W2022932269 @default.
• W1876152197 cites W2040841032 @default.
• W1876152197 cites W2041185415 @default.
• W1876152197 cites W2042819373 @default.
• W1876152197 cites W2044859820 @default.
• W1876152197 cites W2047061170 @default.
• W1876152197 cites W2047478188 @default.
• W1876152197 cites W2049028154 @default.
• W1876152197 cites W2051777375 @default.
• W1876152197 cites W2053979603 @default.
• W1876152197 cites W2058384458 @default.
• W1876152197 cites W2061570300 @default.
• W1876152197 cites W2063329712 @default.
• W1876152197 cites W2071445982 @default.
• W1876152197 cites W2074858975 @default.
• W1876152197 cites W2097349400 @default.
• W1876152197 cites W2099837480 @default.
• W1876152197 cites W2107907789 @default.
• W1876152197 cites W2110233361 @default.
• W1876152197 cites W2114044413 @default.
• W1876152197 cites W2114429672 @default.
• W1876152197 cites W2118660285 @default.
• W1876152197 cites W2126329290 @default.
• W1876152197 cites W2134170928 @default.
• W1876152197 cites W2135634299 @default.
• W1876152197 cites W2142993126 @default.
• W1876152197 cites W2159186412 @default.
• W1876152197 cites W2163934571 @default.
• W1876152197 cites W2167348345 @default.
• W1876152197 cites W2169079203 @default.
• W1876152197 cites W2169330089 @default.
• W1876152197 cites W2292308933 @default.
• W1876152197 doi "https://doi.org/10.1159/000382082" @default.
• W1876152197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25925713" @default.
• W1876152197 hasPublicationYear "2015" @default.
• W1876152197 type Work @default.
• W1876152197 sameAs 1876152197 @default.
• W1876152197 citedByCount "33" @default.
• W1876152197 countsByYear W18761521972015 @default.
• W1876152197 countsByYear W18761521972016 @default.
• W1876152197 countsByYear W18761521972017 @default.
• W1876152197 countsByYear W18761521972018 @default.
• W1876152197 countsByYear W18761521972019 @default.
• W1876152197 countsByYear W18761521972020 @default.
• W1876152197 countsByYear W18761521972021 @default.
• W1876152197 countsByYear W18761521972022 @default.
• W1876152197 countsByYear W18761521972023 @default.
• W1876152197 crossrefType "journal-article" @default.
• W1876152197 hasAuthorship W1876152197A5008989080 @default.
• W1876152197 hasAuthorship W1876152197A5016751794 @default.
• W1876152197 hasAuthorship W1876152197A5017191850 @default.
• W1876152197 hasAuthorship W1876152197A5020634811 @default.
• W1876152197 hasAuthorship W1876152197A5021993357 @default.
• W1876152197 hasAuthorship W1876152197A5022789521 @default.
• W1876152197 hasAuthorship W1876152197A5024660718 @default.
• W1876152197 hasAuthorship W1876152197A5034374147 @default.
• W1876152197 hasAuthorship W1876152197A5037238963 @default.

• next